1/ 🧵Pfizer’s new mRNA flu trial quietly revealed the problem they can’t quite admit....
It’s not the spike. It’s the platform. It's the LNPs.
What did the data show?
nejm.org/doi/full/10.10…
It’s not the spike. It’s the platform. It's the LNPs.
What did the data show?
nejm.org/doi/full/10.10…
2/Pfizer’s mRNA flu vaccine = same tech as COVID shots, just a new mRNA coding for the FLU antigen.
So what happened?
Strong fevers, swollen nodes, fatigue, pain which was identical to the COVID pattern.
Same signature, but NO SPIKE PROTEIN.
Does that mean the toxic driver is the lipid nanoparticle (LNP) system itself?
So what happened?
Strong fevers, swollen nodes, fatigue, pain which was identical to the COVID pattern.
Same signature, but NO SPIKE PROTEIN.
Does that mean the toxic driver is the lipid nanoparticle (LNP) system itself?
3/ Even worse: in the >65 year-old trial dataset (quietly posted on , no press release)…
There’s an important renal (kidney) signal.
Serious kidney adverse events in healthy seniors who were screened to exclude any chronic issues including kidney impairment.
That’s a major pharmacologic red flag.clinicaltrials.gov
There’s an important renal (kidney) signal.
Serious kidney adverse events in healthy seniors who were screened to exclude any chronic issues including kidney impairment.
That’s a major pharmacologic red flag.clinicaltrials.gov
4/ LNPs are not “fat bubbles.”
They’re ionizable cationic amphiphiles (CADs) which are positively charged at acidic pH inside the endosomes.
These molecules are biologically active: they fuse with cell membranes, get trapped in lysosomes, and can trigger phospholipidosis and mitochondrial stress.
They behave like drug molecules, not inert carriers.
They’re ionizable cationic amphiphiles (CADs) which are positively charged at acidic pH inside the endosomes.
These molecules are biologically active: they fuse with cell membranes, get trapped in lysosomes, and can trigger phospholipidosis and mitochondrial stress.
They behave like drug molecules, not inert carriers.
5/ They're like mini‑detergents or steel wool scrubbing your cell membranes (not quite, but well, you get the picture).
They dissolve INTO cell membranes, scramble lipids, activate complement cascades ( fevers/chills), and distribute through liver, spleen, kidney, ovaries, etc
They dissolve INTO cell membranes, scramble lipids, activate complement cascades ( fevers/chills), and distribute through liver, spleen, kidney, ovaries, etc
6/ If the spike is removed but the inflammation remains, you’ve identified the real culprit.
The antigen (spike protein, hemagluttinin, the RSV proteint) isn’t driving these side effects.
The "platform" is.
Pfizer’s own flu trial data quietly confirmed it.
The antigen (spike protein, hemagluttinin, the RSV proteint) isn’t driving these side effects.
The "platform" is.
Pfizer’s own flu trial data quietly confirmed it.
7/ these kidney signals, may be associated with the LNPs CAD-like activity, similar to how aminoglycosides, another CAD causes kidney damage (i.e. gentimicin, tobramycin, amikacin etc)
Other possibilities include microclots gumming up the renal tubules but this too would need to be initiated by the LNPs because there is no spike protein in these mRNA influenza vaccines..
Other possibilities include microclots gumming up the renal tubules but this too would need to be initiated by the LNPs because there is no spike protein in these mRNA influenza vaccines..
8/ I think regulators should look at standard CAD pharmacology screens for the LNPs:
• phospholipidosis assays
• lysosomal trapping quantification
• kidney & liver ultrastructure studies
• full lipid biodistribution & metabolite tracking
These are basic toxicology 101
• phospholipidosis assays
• lysosomal trapping quantification
• kidney & liver ultrastructure studies
• full lipid biodistribution & metabolite tracking
These are basic toxicology 101
9/ The LNPs are not inert. They’re active compounds.
They act like amphiphilic drugs, pharmacological detergents, which cause inflammation, cellular stress, and a kidney signal that cannot be ignored imho.
Should amphiphilic ionizable lipids, be used for annual or chronic injections? The answer is obvious.
They act like amphiphilic drugs, pharmacological detergents, which cause inflammation, cellular stress, and a kidney signal that cannot be ignored imho.
Should amphiphilic ionizable lipids, be used for annual or chronic injections? The answer is obvious.
10/ When the plug (antigen) changes but the reaction stays the same, the platform IS the drug.
And the drug is toxic. We need the FDA/EMA/HC to act
Read my full analysis here: mariagutschi.substack.com/p/what-the-new…
And the drug is toxic. We need the FDA/EMA/HC to act
Read my full analysis here: mariagutschi.substack.com/p/what-the-new…
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