10 Indisputable facts that are now scientific consensus about SARS-CoV-2(12/17/2025):
COVID is NOT primarily a respiratory disease.
It is a systemic vascular-immune disease causing endothelial injury, microvascular thrombosis, and immune dysregulation. This is concerning because the injury is cumulative with each infection(endothelium does not easily regenerate).
It is a systemic vascular-immune disease causing endothelial injury, microvascular thrombosis, and immune dysregulation. This is concerning because the injury is cumulative with each infection(endothelium does not easily regenerate).
Persistent immune dysregulation is common(not rare).
T-cell exhaustion, impaired antigen presentation, aberrent IFN signaling, reactivation of latent viruses, and reduced naive T-cells accelerate immune aging and increase risk of autoimmunity, cancer, and chronic infection.
T-cell exhaustion, impaired antigen presentation, aberrent IFN signaling, reactivation of latent viruses, and reduced naive T-cells accelerate immune aging and increase risk of autoimmunity, cancer, and chronic infection.
Viral persistence / Antigen persistence is real.
SARS-CoV-2 and it's proteins persist in the gut, bone marrow, brain, lymphoid tissue, and endothelium for months/years causing T-cell exhaustion, autoimmunity, amyloidogenesis, and blood disorders.
SARS-CoV-2 and it's proteins persist in the gut, bone marrow, brain, lymphoid tissue, and endothelium for months/years causing T-cell exhaustion, autoimmunity, amyloidogenesis, and blood disorders.
COVID increases longterm cardiovascular risk.
Previous infection increases risk of infarct, stroke, arrhythmias, and heart failure for 1-3 years even if the infection was "mild"(reinfections worsen risk).
Previous infection increases risk of infarct, stroke, arrhythmias, and heart failure for 1-3 years even if the infection was "mild"(reinfections worsen risk).
Neurological injury occurs with or without neuroinvasion.
COVID-related brain injury is immune-mediated, vascular, and/or the result of antigen persistence causing chronic microglial dysfunction, white matter injury, BBB disruption, and cognitive decline(injury is cumulative).
COVID-related brain injury is immune-mediated, vascular, and/or the result of antigen persistence causing chronic microglial dysfunction, white matter injury, BBB disruption, and cognitive decline(injury is cumulative).
Reinfections are NOT benign.
Each reinfection increases risk of Long Covid, cardiovascular events, neurological injury, and further immune dysfunction.
Each reinfection increases risk of Long Covid, cardiovascular events, neurological injury, and further immune dysfunction.
Bone marrow and hematopoietic injury is real.
COVID disrupts HSCs, erythropoiesis, megakaryopoiesis, and can cause bone marrow failure leading to anemias, cytopenias, amyloid disorders, and malignancies.
COVID disrupts HSCs, erythropoiesis, megakaryopoiesis, and can cause bone marrow failure leading to anemias, cytopenias, amyloid disorders, and malignancies.
Children are not immune to longterm effects.
While acute mortality is low, many children experience Long Covid, cognitive dysfunction, vascular disease, diabetes, and dysautonomia. Longterm immune/vascular impact of COVID is likely cumulative but unknowable for decades.
While acute mortality is low, many children experience Long Covid, cognitive dysfunction, vascular disease, diabetes, and dysautonomia. Longterm immune/vascular impact of COVID is likely cumulative but unknowable for decades.
"Mild" infection does not mean mild disease.
Severity of acute symptoms is a poor prognostic for longterm outcomes. Asymptomatic infections can still develop Long Covid, cardiac injury, neuronal injury, and autoimmunity. There is NO symptom-based risk stratification whatsoever.
Severity of acute symptoms is a poor prognostic for longterm outcomes. Asymptomatic infections can still develop Long Covid, cardiac injury, neuronal injury, and autoimmunity. There is NO symptom-based risk stratification whatsoever.
Long Covid is a major chronic disease burden.
Long Covid is a real, common, heterogeneous, and underdiagnosed disability affecting a consistently growing number of people.
Long Covid is a real, common, heterogeneous, and underdiagnosed disability affecting a consistently growing number of people.
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