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Daniel Park Profile picture
@Daniel_E_Park
Dec 23 • 4 tweets • 2 min read • Read on X
Quick personal note. A close friend recently died from a heart attack a week after COVID.
COVID increases risk of cardiac events.
It may have faded from the news cycle, but COVID continues to take people from their families. Please take it seriously.
COVID increases risk of heart attack and heart disease for years following infection.
nature.com/articles/s4416…
nature.com/articles/s4146…
ahajournals.org/doi/10.1161/AT…
You can disagree with the government’s COVID response and still take the virus seriously.

The virus doesn’t care about politics. Last season, COVID killed as many people as a historically severe flu season.
Vaccines continue to reduce risk of infection and severe illness (both mRNA and conventional protein-based options available, i.e. Novavax).
Clean air helps: filtration, masks, or even opening windows.
Wishing everyone a safe and healthy holiday season.

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More from @Daniel_E_Park

Daniel Park Profile picture
Dec 6
I’ve gotten questions about whether JN.1- or LP.8.1-based COVID vaccines are better.
Short answer: both should be similarly effective against currently circulating strains. The important thing is to get vaccinated.
Longer answer: see thread Image
We are fortunate in that nearly all currently circulating strains stem from JN.1 (i.e. JN.1 lineage). JN.1 first emerged in late 2023 and became dominant during the winter 2023-2024 surge. Since then, we have gone through waves of KP.2, KP.3, XEC, and in spring 2025, LP.8.1.
Given the dominance of LP.8.1 during the spring, many suspected the WHO committee on COVID-19 vaccine composition (TAG-CO-VAC) and the US FDA Advisory Committee (VRBPAC) would select LP.8.1. However, selection of a dominant strain (assuming forward drift) is potentially flawed.
Read 24 tweets
Daniel Park Profile picture
Nov 8
New study evaluating vascular and inflammatory diseases after COVID-19 infection and vaccination in nearly 14 million children.
Large persistent increase in major cardiovascular risks following infection. A small transient myocarditis risk following vaccination Image
Paper:

"COVID-19 infection in children & young people was associated w/ elevated risks... including venous thromboembolism, thrombocytopenia, myocarditis, & pericarditis particularly in the first month... w/ some risks remaining elevated up to 12 months"thelancet.com/journals/lanch…
"By contrast, COVID-19 vaccination was associated with a short-term increased risk of myocarditis or pericarditis, mainly within the first 4 weeks. However, no increased risk was observed beyond that period, and there was no evidence of long-term myocarditis signal"
Read 7 tweets
Daniel Park Profile picture
Nov 2
Excellent study on correlates of protection for nuvaxovid / novavax. Higher IgG and nAb levels are excellent predictors for risk of any and severe infection. Helpful data on durability as well. 🧵 Image
Paper: academic.oup.com/cid/advance-ar…

This study group received the original wuhan vaccine and assessed IgG and nAb levels vs Delta. This phase 2 follows the initial CoP analysis, which had no severe cases. That is great, but precluded analysis for severe COVID: nature.com/articles/s4146…
A key finding was that there were no severe cases above the 33rd percentile of IgG levels at day 35 - i.e. based on initial immune responses, no one with an average immune response had severe illness. Image
Read 8 tweets
Daniel Park Profile picture
Oct 31
Excellent systematic review of COVID, flu, and RSV vaccines. Hundreds of studies, and millions of individuals represented, all demonstrating that these important vaccines help reduce the risk of severe illness and hospitalization. Image
Link to study:

Remember that the COVID vaccine effectiveness of ~50% is comparing up to date vaccination vs a background of infection acquired and prior vaccine immunity.nejm.org/doi/full/10.10…
Protection against long COVID in children and adults was also high (~60%) and lines up nicely with prior large studies
thelancet.com/journals/lanre…
Read 6 tweets
Daniel Park Profile picture
Sep 23
Lost in the recent ACIP meeting: A lack of distinction between non-mRNA Novavax & mRNA. They voted on restrictions largely based on mRNA-specific concerns (many false assertions) when these issues flat-out don't apply to Novavax. A brief overview
The ACIP voted to add language about six additional risks with COVID vaccines. Let's see how those apply to Novavax Image
1. Poor effectiveness & duration?
Effectiveness of COVID vaccines remains strong (around 50%). Importantly, these are population level estimates comparing against a background of infection-acquired immunity (see CDC slide). Image
Image
Read 11 tweets
Daniel Park Profile picture
Aug 24
As anticipated, COVID levels are rising nationally with a late summer wave.
Wastewater detection rising quickly.
Early increases in hospitalization rates (those lag infections and viral detection).
I would expect rates to continue accelerating as kids go back to school. Image
Rates are variable by region. For example Texas is matching the highest levels in the last two years. Some areas remain at low levels. Check your state
cdc.gov/nwss/rv/COVID1…Image
Emergency department rates (early clinical indicator) remain relatively low, but there are substantial increases nationally Image
Image
Read 8 tweets

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