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Hiroshi Yasuda (保田浩志) Profile picture
@Yash25571056
Jan 8 • 1 tweets • 1 min read • Read on X
"Increasing evidence indicates that the GI tract is a critical target for SARS-CoV-2, which significantly influences viral pathogenesis, disease severity, and patient outcomes..
Our previous work revealed high SARS-CoV-2 aerosol concentrations in toilets used by COVID-19 patients, implying infections in the intestines and potential fecal-oral transmission..
Prolonged shedding of SARS-CoV-2 viral RNA in stools months after infection indicates a long-lasting viral reservoir in the GI tract..
In some patients with long COVID, viral RNA and the spike protein have been shown to persist in the intestine for months..
In this study, we identified peroxisomes as central mediators of intestinal pathology in long COVID, in which viral reservoirs disrupt peroxisomal function, impair ISC(intestinal stem cell)-mediated repair, and compromise the intestinal barrier, leading to persistent GI symptoms..
the pathogenesis of long COVID involves not only uniform systemic regulation but also tissue-specific disruptions and damage caused by localized intestinal viral reservoirs.."

A good gut is crucial.

'Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID'
cell.com/developmental-…

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More from @Yash25571056

Hiroshi Yasuda (保田浩志) Profile picture
Feb 1, 2023
@PaulRoundy1 No, Paul. I see that the neurologic complications in children is becoming more prevalent since last year (i.e., after the appearance of the Omicron strain).
@PaulRoundy1 FYI, in Japan, among the officially reported COVID deaths of children from Jan. to Sep., 2022, the major endogenous cause was central nervous system symptoms (19/50; 38%), which is much higher than circulatory (18%) & respiratory (8%) ones.

[Source]
niid.go.jp/niid/ja/2019-n…
@PaulRoundy1 I should note that, as a feature of deaths due to the central nervous system abnormalities, the durations from onset to death of those children were quite short: 3.0 days in median with 0-2 days: 46%, 3-6 days: 29% & 7 days or more: 25%).

niid.go.jp/niid/ja/2019-n…
Read 4 tweets
Hiroshi Yasuda (保田浩志) Profile picture
Sep 26, 2022
Let me note below the failures that we experienced in international cooperation for controlling the COVID-19 pandemic:
1) the lack of timely notification of the initial outbreak of COVID-19;
...
(1/6)
2) costly delays in acknowledging the crucial airborne exposure pathway of the virus, and in implementing measures;
3) the lack of coordination among countries regarding suppression strategies;
(2/6)
4) the failure of governments to examine evidence and adopt best practices for controlling the pandemic;
5) the shortfall of global funding for low-income and middle-income countries (LMICs);
(3/6)
Read 6 tweets
Hiroshi Yasuda (保田浩志) Profile picture
Jul 4, 2022
1/11
The National Institute of Infectious Diseases (NIID), the authority on infectious disease issues in Japan, published a report on 30 June 2022 entitled "Acute hepatitis of unknown etiology in children in Japan (1st report)".

niid.go.jp/niid/ja/jissek…
2/11
The report revealed details of pathogen testings regarding the children's acute hepatitis for different age groups based on of a survey performed by the Ministry of Health, Labor and Welfare of Japan (& NIID) for the period from 1 October 2021 to 23 June 2022.
3/11
Among 62 children (male: 34, female: 28, median age: 5 yo) with the acute hepatitis of unknown etiology,
- 57 of 61 cases (93%) were detected in the week of 14 February 2022 or later.
- 12 of 55 cases (22%) were at least once vaccinated;
Read 11 tweets
Hiroshi Yasuda (保田浩志) Profile picture
Jun 24, 2022
1/3
 In Japan, another 4 children (62 in total) hospitalized with unknown-cause acute hepatitis were reported - as of 24 June 2022.

mhlw.go.jp/content/109060…
2/3
 The 62 cases met the following criteria:
-Period: From October 1, 2021 to June 23, 2022;
-Patient: Hospitalized children of 16 y/o or younger;
-Symptoms: Acute hepatitis with AST or ALT exceeding 500 IU/L without involvement of hepatitis A to E viruses.
3/3
 Among the 62 cases,
- adenovirus positive: 5 cases (type 1 & 2: 2 cases and type unknown: 3 cases);
- SARS-CoV-2 positive:5 cases;
- these PCR tests were performed when their symptoms were recognized;
- liver transplant: 0;
- 7 cases are still under complete checkup.
Read 4 tweets

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