”Post-COVID-19 cognitive dysfunction appears to follow a temporal course, evolving from acute focal deficits in attention, working memory, and executive function to more persistent multidomain impairments..
This analysis shows that several inflammatory and viral cytokines remain elevated beyond the acute phase and are associated with cognitive deficits..
The prevalence estimates [of cognitive dysfunction] vary depending on the methodology used and the time of assessment but generally range between 58% and 81% in hospitalized samples, reflecting a significant impact on cognitive function.
In addition, a substantial number of patients, approximately 34%, report subjective complaints, mainly related to attention and naming..
Patients who experienced acute neurological symptoms such as headache, anosmia, or dysgeusia were more likely to show deficits in domains such as attention, memory, and executive functions.."
Do you remember when you had a headache?
'Cognition, cytokines, blood–brain barrier, and beyond in COVID-19: A narrative review' mdpi.com/1422-0067/27/1…
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@PaulRoundy1 No, Paul. I see that the neurologic complications in children is becoming more prevalent since last year (i.e., after the appearance of the Omicron strain).
@PaulRoundy1 FYI, in Japan, among the officially reported COVID deaths of children from Jan. to Sep., 2022, the major endogenous cause was central nervous system symptoms (19/50; 38%), which is much higher than circulatory (18%) & respiratory (8%) ones.
@PaulRoundy1 I should note that, as a feature of deaths due to the central nervous system abnormalities, the durations from onset to death of those children were quite short: 3.0 days in median with 0-2 days: 46%, 3-6 days: 29% & 7 days or more: 25%).
Let me note below the failures that we experienced in international cooperation for controlling the COVID-19 pandemic: 1) the lack of timely notification of the initial outbreak of COVID-19;
...
(1/6)
2) costly delays in acknowledging the crucial airborne exposure pathway of the virus, and in implementing measures; 3) the lack of coordination among countries regarding suppression strategies;
(2/6)
4) the failure of governments to examine evidence and adopt best practices for controlling the pandemic; 5) the shortfall of global funding for low-income and middle-income countries (LMICs);
(3/6)
1/11
The National Institute of Infectious Diseases (NIID), the authority on infectious disease issues in Japan, published a report on 30 June 2022 entitled "Acute hepatitis of unknown etiology in children in Japan (1st report)".
2/11
The report revealed details of pathogen testings regarding the children's acute hepatitis for different age groups based on of a survey performed by the Ministry of Health, Labor and Welfare of Japan (& NIID) for the period from 1 October 2021 to 23 June 2022.
3/11
Among 62 children (male: 34, female: 28, median age: 5 yo) with the acute hepatitis of unknown etiology,
- 57 of 61 cases (93%) were detected in the week of 14 February 2022 or later.
- 12 of 55 cases (22%) were at least once vaccinated;
2/3 The 62 cases met the following criteria:
-Period: From October 1, 2021 to June 23, 2022;
-Patient: Hospitalized children of 16 y/o or younger;
-Symptoms: Acute hepatitis with AST or ALT exceeding 500 IU/L without involvement of hepatitis A to E viruses.
3/3 Among the 62 cases,
- adenovirus positive: 5 cases (type 1 & 2: 2 cases and type unknown: 3 cases);
- SARS-CoV-2 positive:5 cases;
- these PCR tests were performed when their symptoms were recognized;
- liver transplant: 0;
- 7 cases are still under complete checkup.