CaffeenHeadache™️ Profile picture
May 7 • 9 tweets • 3 min read • Read on X
đź§µA very narrow but serious set of overlaps exists:

U.S. scientists linked to CDC and NIH viral surveillance/modeling programs co-authored key hantavirus ecology papers with researchers from China relying on Chinese surveillance data, raising biosecurity red flags.

Similarities to COVID-19 are clear.
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1/ Qualifying researcher #1: Gerardo Chowell (Georgia State University, School of Public Health).

Chowell has NIH Fogarty International Center ties for international epidemiology and population studies.

He contributes to CDC-linked pathogen modeling, including analysis of national wastewater surveillance (NWSS) viral data and service on the editorial board of CDC’s Emerging Infectious Diseases journal.

His hantavirus focus: transmission dynamics, spillover forecasting, and ecological drivers.
2/ Chowell co-authored the 2018 PNAS paper “Urbanization prolongs hantavirus epidemics in cities.”

It analyzed 48 years of HFRS data from Hunan Province, China—linking urbanization, migration, rodent shifts, land use, and seasonality to prolonged outbreaks.

Multiple co-authors are affiliated with Hunan Provincial institutions (including data from Hunan CDC).

This work required deep access to Chinese field surveillance and rodent sampling.
3/ Qualifying researcher #2: Ottar N. Bjørnstad (Penn State, Center for Infectious Disease Dynamics).

Bjørnstad is an NIH Fogarty Senior Research Fellow specializing in epidemic modeling that directly supports surveillance and forecasting. His hantavirus research mirrors Chowell’s—ecological spillover mechanics using real-world data.

He too is a co-author on the exact same 2018 PNAS Hunan hantavirus paper.Image
5/ The 2018 paper’s Chinese co-authors

Shixiong Hu, Yapin Li, and others from Hunan Province provided the core dataset from mainland Chinese public health and rodent monitoring networks.

Funding was heavily Chinese (National Natural Science Foundation of China, Hunan provincial grants).

No equivalent U.S.-only data could have produced these insights.
6/ National security parallels to COVID-19 lab-leak and origin debates are striking:

CDC/NIH-supported U.S. experts modeling zoonotic hantavirus spillover using data from Chinese institutions (mainland facilities with documented biosecurity challenges).

Hantavirus work involves high-risk rodent handling, viral characterization, and BSL-3/4 practices—precisely the domain alleged in early COVID investigations.

Collaboration creates pathways for technology transfer, data access, and potential dual-use knowledge to a strategic adversary.

Any mainland China partner (not just WIV) is a quagmire.
7/ Bottom line:

Taxpayer-funded CDC and NIH viral surveillance programs backed researchers who built scientific bridges to mainland Chinese institutions on hantavirus ecology.

The same modeling tools, data pipelines, and spillover frameworks used here echo those central to COVID-origin questions.

In an era of great-power competition and documented Chinese biosecurity gaps, these ties aren’t “normal science”—they’re national security concerns demanding strict scrutiny, vetting, and limits. Oversight matters.
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More from @CaffeenHeadache

May 7
Tagging @FBIDirectorKash @TheJusticeDept @DAGToddBlanche @DNIGabbard @CIADirector for fear of public disinterest
1/ Let's turn this into another specifically targeted thread underneath your tags!

We conducted an exhaustive search of peer-reviewed literature for collaborative CRISPR or genomic editing research on hantavirus involving both Chinese and American scientists/researchers—covering any work since 1980 on both host-side and pathogen-side genomic interventions.

The search spanned:
PubMed, Web of Science, bioRxiv
International databases
Institutional repositories

50 specific search queries combining: hantavirus, CRISPR, genomic editing, China, USA, collaboration

🔍 Here's what we found:Image
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2/ WHAT WE DID FIND: Standalone CRISPR Hantavirus Work

China-Only CRISPR Research:đź§Ş "Sensitive & Visualized Detection of Hantavirus Using CRISPR/Cas12a" (2025, J Med Virol)
Wuhan University, Southern Medical University, CAMS, South China University of Technology

AutoCORDSv2-designed CRISPR detection system
42 copies/reaction sensitivity
All Chinese authors & institutions (1)Image
Image
Read 8 tweets
May 7
đź§µAnother continuing thread branch

1/ 2021 PLOS Pathogens (Henan Univ + Western Univ of Health Sciences + Univ Kansas Med Ctr): hantaviruses use host factor **P58IPK** to counter PKR defenses. (1)
2/ China has a growing “CRISPR + hantavirus” literature—but it’s mainly **diagnostics**:

CRISPR-Cas systems used to detect hantavirus RNA quickly/sensitively.

Useful for surveillance, but it’s not editing the virus genome. Example: 2025 J Med Virol CRISPR/Cas12a work. (2)
3/ **Reverse genetics** is closest to “editing hantavirus”:

Recover virus from cloned genome segments. Milestone: “Rescue of Hantaan virus minigenomes” (2003). A 2023 JID review notes the field long lacked full-length clone systems—so true genome-editing papers are scarce. (3)(4)
Read 10 tweets
May 6
🧵China isn't the only..."red flag" 🇨🇳 involved in Gain-of-Function-adjacent research when it comes to Hantavirus...

None other than Ukraine - where there "are no biolabs".
🇺🇦🇺🇦🇺🇦🇸🇩🇸🇩🇸🇩 Image
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2/ The U.S.–Ukraine “biolab” record starts with BTRP:

DTRA says the program partnered with Ukraine from 2005 to improve peaceful biological detection/diagnostic capacity and reduce risks from dangerous pathogens. (1)
gusquixote.com/article/part-t…
3/ DTRA says the U.S. invested about $200M in Ukraine

They supported 46 Ukrainian labs, health facilities, and diagnostic sites—focused on biosafety, biosecurity, surveillance, and human/animal health. (2)Image
Image
Read 12 tweets
May 6
đź§µHantavirus an Anthony Fauci Gain-of-Function Frankenstein gone wrong?

Public records show U.S.–China overlap in hantavirus clinical treatment research, surveillance, molecular epidemiology, phylogenetics, reservoir-host research, and natural reassortment/pathogenicity studies.
2/ Hantavirus U.S.–China overlap isn’t one visible “joint GOF program.”

Public record points to cooperation in treatment trials, surveillance, molecular epidemiology, host-jump ecology, reassortment analysis, and countermeasures. (1)Image
3/ The clearest direct overlap:

USAMRIID worked with scientists/physicians in Wuhan in the 1980s on a randomized, double-blind ribavirin trial for HFRS/Hantaan disease.

A 2023 history calls it a formal USAMRIID–Chinese govt collaboration. (2)Image
Read 14 tweets
May 6
1/ Hantavirus spillover research in China with U.S.-affiliated scientists clusters into 3 lanes:

Chinese human HFRS surveillance.
Chinese rodent/isolate genetics.
Ecological risk modeling.

“American scientists” here means U.S. institutional affiliation at publication, not confirmed nationality. (1)Image
2/ One early U.S.-China trail runs through USAMRIID.

In 1993, S.Y. Xiao and C.S. Schmaljohn characterized HV114, a hantavirus isolated from an HFRS patient in Hubei, China, using antigenic comparison and M-segment sequencing. (1)Image
3/ The University of Georgia trail centers on Zhen F. Fu and Chinese collaborators.

Their China work covered rodent reservoirs, human/animal infections, isolate diversity, and reassortment/spillover signals, including Guizhou and Zhejiang studies. (2)Image
Read 14 tweets

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