Parmita Mishra Profile picture
May 14 8 tweets 2 min read Read on X
voronoi diagrams are how you divide space when you know where everything is

school districts or cell tower coverage

the kind of problem you solve with coordinates, a global view, and a computer.

a CSHL group just showed the chinese money plant solves it in its leaves. Image
each leaf has tiny pores called hydathodes around each pore, a closed loop of veins

when you map them, they are textbook voronoi cells with the hydathodes as the seed points. perfect geometry.
but a leaf cell has no coordinates. no ruler or map of the other hydathodes. it can only sense its immediate neighbors.

the trick: each cell follows one stupid local rule about pushing auxin to its neighbor. no global plan at ALL

just chemistry flowing forward in time
where flux from two pores meets at equal magnitude, a vein forms. that ridge IS the voronoi boundary.

the geometry isn’t programmed it’s just the steady state of a PDE running on a sheet of cells
the mature leaf is the answer to a computation that already finished.

there is zero information in the static leaf about how the auxin flowed, what the transients looked like, which cell did what when.
you could stare at a million leaves trying to infer “the rule.” you would be wrong. there is no rule

there is only the trajectory.
every static image of a living system is the screenshot of a computation nobody filmed.

we keep photographing the answer and wondering why we can’t reverse-engineer the math.

remind you of something?
@prof_g

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More from @parmita

Apr 12
your ribosome is not a machine. it’s a computer. and we just found DHX29, which i’d call part of its operating system. thread 🧵 Image
your DNA is an instruction manual written in three-letter words called codons. each word tells the cell which amino acid to add when building a protein Image
but the ribosome — the thing that actually builds the protein — can’t read DNA directly. it reads a copy called mRNA. and it doesn’t go fetch the amino acids itself Image
Read 15 tweets
Apr 1
As someone who actively works in drug discovery, I want to dispel a myth.

Stimulants were not “designed for ADHD.” They were discovered by accident in the 1930s because they calmed hyperactive boys.

Also the origin story of the most prescribed psychiatric drugs in history.
🧵 Image
The entire research pipeline - the clinical trials, the diagnostic criteria, the dosing models - was built around one phenotype: hyperactive boys who couldn’t sit still in class.

Most stimulant studies were conducted on white males. The DSM criteria? Based on young boys. Image
I have ADHD. I’ve had it diagnosed since I was very young. And my meds genuinely helped me. I’m not anti-medication. Stimulants changed my life in real ways. But they fixed my hyperactivity. They did NOT fix my inattentiveness.

That’s not a coincidence.
Read 21 tweets
Apr 1
🚨 There is a new COVID variant: Cicada.

It has spread around 25 US states. <1% prevalence in US but up to 30% of cases in Europe are Cicada.

* carries 70–75 genetic mutations in its spike protein
^ double the amount found in other recent dominant strains like JN.1.
🧵
Why is it called Cicada?

It’s “hibernation” pattern.

In November 2024, it was first detected.

September 2025: waste water detections increase

January 2026: first (human) patient.
Cicada has not yet dominated other strains.

If it does? We are screwed. It could absolutely drive a summer surge.

Crucially, it is more likely to hit older people and the immunocompromised.

Stay cautious!
Read 16 tweets
Mar 21
I just asked myself the most important question I’ve ever asked.

What if, god forbid, I had cancer right now? How would I save my life and would I be able to do it without Precigenetics?

The answer made me cry.

Here’s EXACTLY how I would save my own life TODAY. 🧵
Let me show you both paths. What happens today, without this platform

and what I’d actually do if I had one. Assume I had the permits to use my cells, and I could do what I want.

Then you tell me which world you want to live in.
the current reality for every cancer patient on earth:

You get a biopsy. Your tissue is fixed, stained, and sent to a pathology lab. It’s dead. The cells you need answers from are killed in the process of examining them.

You wait.
Read 32 tweets
Oct 15, 2025
I keep saying “drug discovery” but most of my audience does not understand what this means.

Here’s a thread I worked on over the past week trying to distil down drug discovery - and why it matters in the age of AI.

OPEN THE THREAD 🧵 Image
Drug discovery is how molecules become medicine.
A $180 billion guessing game where up to 97% of candidates fail in trials.

We can now predict protein folds (thanks to AlphaFold), but still cannot simulate what a drug actually does to a living cell in real time.
At its core, drug discovery asks one question:

=> What happens inside a cell when we “perturb” it? (drug it)

Traditional biology answers by destroying the cell to measure it.

Every assay is a snapshot. Every snapshot costs reagents, time, and lives. Image
Read 23 tweets
Sep 26, 2025
how do we know that people in the past had cancer and when did we even know what cancer was?

a word for cancer existed long before microscopes or pathology.

the history of cancer is far more exciting than we realize.

🧵
the idea is older than modern medicine. Hippocrates (400 BCE) used the word karkinos (crab) for tumors with “claw-like” spread. Galen (200 CE) expanded it. the word cancer is a translation of this lineage.
this existed across civilizations

in India, texts like Sushruta Samhita circa 600 BCE described “arbuda”: hard, immobile, enlarging masses that ulcerated and killed slowly. not called “cancer,” but the descriptions line up with malignancies.
Read 16 tweets

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