Paul Saladino, MD Profile picture
Chief Radical Officer (CRO) of #theremembering. Lover of wild places. Eater of a #animalbased diet. #bitcoin
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Jun 28, 2021 6 tweets 1 min read
So let me get this straight...Covid is an illness that:

is much worse in the obese but we haven’t recommended people lose weight or think about diet... much worse in people with low vitamin D but we were told to stay indoors and parks were closed...
Sep 19, 2020 5 tweets 1 min read
Dogmatism has no place in free thinking. Challenge everything you think you know.

How much of what you think you know are you willing to question? How open-minded are you, really? Despite the fact that I consider myself a part of the keto and carnivore communities, I continue to be disappointed by the amount of dogmatic thinking within these.
Sep 18, 2020 4 tweets 1 min read
You know we have forgotten our ancestral past when olive oil is thought to be healthier than animal fat. 🤦‍♂️ News flash: Olive oil is a fairy tale. There's zero magic here. If you want real nutrition eat animals from nose to tail!
Sep 16, 2020 5 tweets 1 min read
Animal-based diets, like a nose to tail carnivore diet, are about much more than food. They are a stepping stone to remembering where we have come from as humans.

Forgetting this history has led to myriad health and social ills today. We no longer eat the way that our ancestors have, shunning the most treasured foods (animal organs and meat) in favor of survival foods like seeds, leaves, and even highly processed seed oils.
Sep 15, 2020 4 tweets 1 min read
Hypertrophic adipocytes lead to metabolic dysfunction

4HNE (and other OxLAMs) lead to hypertrophic (vs hyperplastic) adipocytes.

Excess linoleic acid in the diet leads to increased production of 4HNE (& OxLAMs).

Translation: Linoleic acid makes you fat and sick. Get it? Much deeper discussion of this in this week's podcast found here:
Sep 15, 2020 4 tweets 1 min read
Seeds (nuts, seeds, grains, legumes) are some of the most highly defended parts of plants. Peanuts, cashews, almonds, and even your beloved macadamia nuts do not love you back!

And neither does Kale, but you knew that already! 🤣 In addition to being full of digestive enzyme inhibitors, lectins, phytates, and oxalates, many plant seeds are also quite high in linoleic acid, an omega-6 PUFA which appears to be signaling your fat cells to grow.
Sep 10, 2020 5 tweets 1 min read
We have become a species of domesticated humans, and have lost touch with our wild nature.

We no longer know what to eat or how to live, and this is literally killing us. 💀 Wild humans know that animal organs and meat are the optimal foods and seek them preferentially.

Domesticated humans shop in grocery stores and make processed plant foods/seed oils the majority of their diet.
Sep 1, 2020 4 tweets 1 min read
The autoimmune carnivore diet (AIC): grass-fed beef, organs, bone broth, and salt +/- carbohydrate source depending on personal preference.

I'm very interested to see how most autoimmune conditions respond to this simplified but nutritionally complete approach. How many are diagnosed every day with autoimmune conditions and told there is no cure then quickly sentenced to a lifetime of immunosuppressive medications?

How many millions could be helped with an approach like AIC?
Aug 29, 2020 4 tweets 1 min read
Thinking about things from the perspective of plants makes nutrition much simpler. Plants don't want their leaves, stems, and seeds* (legumes, nuts, seeds, grains) eaten, but they can't run away or defend themselves like animals... Thus, they've had to develop myriad defense chemicals to dissuade animals from over-consuming them. It's not a question of if plants contain defense chemicals, only if you are able to adequately detoxify these.

Why take the excess risk unless you are forced to?
Aug 25, 2020 6 tweets 1 min read
While most now accept that metabolic dysfunction* is at the root of today's chronic disease epidemic, we can't seem to agree on what causes this in the first place.

Hint: it's not carbohydrates Once metabolic dysfunction has occurred, humans certainly become carbohydrate intolerant, and lowering the intake of this macronutrient can be quite helpful in this situation, but it's not the root of the problem.
Aug 22, 2020 4 tweets 1 min read
Anyone who thinks a plant-based diet is viable for humans hasn't spent enough (any?) time in the wilderness. 99.9% of animals are edible, but only a fraction of plants won't kill you swiftly or cause massive GI distress. I climbed a mountain in Montana (Sacagewa peak, 9843ft) and saw many animals that could have been dinner but not a single plant that would provide any significant nutritive value. 🤯
Aug 18, 2020 5 tweets 1 min read
The myriad number of ways that humans have devised to partially detoxify plant foods (fermentation, cooking, dehulling, sprouting...) should be some indication of the lesser relative value of these in our diets, historically. Conversely, organs and meat from animals have always been the most prized foods our ancestors sought out.
Aug 17, 2020 4 tweets 1 min read
After being widely derided, the scientific and media communities of the world (including the NYT!) are finally waking up to the reality that herd immunity is the only way forward. How ironic. I guess this means we better be metabolically healthy when we are exposed.🤦‍♂️ Image Too bad we didn't realize this sooner. Our populations have been getting fatter, sicker, and paler the last 6 months and decreasing the ability of their immune system to fight off this (or any other) virus.
Aug 16, 2020 6 tweets 1 min read
In the setting of insulin resistance, carbohydrates fan the flames of metabolic dysfunction, but they didn't cause the blaze. We know that once metabolic dysfunction has developed, humans become carbohydrate intolerant, and that removal of carbs (nose to tail carnivore diet, keto diet) can be helpful to lower insulin signaling in this setting... I *might* have written a book about this.
Aug 15, 2020 8 tweets 1 min read
Hypothesis: linoleic acid acts as an evolutionary signal to our fat cells that they should grow. Historically, we would have eaten more of this during times of scarcity. This is nature telling us that "winter is coming." Linoleic acid-rich foods like nuts and seeds would have been these signals in the past at a low level, but today with our constant over-consumption of linoleic acid in vegetable oils and fat from monogastric animals fed corn and soy there's a constant signal for us to get fat.
Aug 14, 2020 6 tweets 1 min read
When will we learn that we cannot hide from coronavirus? It's not a question of if you are exposed but when, and when that happens, how metabolically healthy you are. And with metabolic health as a key determinant in your ability to combat this virus, wouldn't it be important to know what promotes this and decreases it?
Aug 11, 2020 5 tweets 1 min read
Can someone please show me a study that shows carbohydrates causing diabetes in metabolically healthy individuals? Anyone? To indict this macronutrient as the cause of an epidemic of herculean proportions without clear science to corroborate such accusations is unfortunate and misleading.
Aug 9, 2020 5 tweets 1 min read
Please don't ask me what foods are "carnivore." I'm much more interested in your health than dogmatic adherence to a limiting system of beliefs that doesn't allow for growth and learning. I do believe that for most people a diet composed mostly of animal foods eaten nose to tail will result in optimal health, but I also acknowledge that this may look different between individuals.
Aug 9, 2020 5 tweets 2 min read
It's more than a little ironic when @SBakerMD with a fasting blood sugar of 126mg/dl and an HgbA1c of 6.3 tries to call me out for including honey in my diet 🤔. My fasting blood sugar is 74mg/dl and I've publicly shared my CGM data to show very low glycemic variability and clear insulin sensitivity while including moderate amounts of honey (a few tablespoons per day) in my diet. My fasting insulin is <3uIU/ml. Image
Jul 31, 2020 6 tweets 1 min read
Metabolic dysfunction is the true pandemic of our time.

Mainstream dietary advice to shun animal fat in favor of vegetable oils leads to metabolic dysfunction.

You can thank mainstream medicine's evolutionarily inconsistent dietary advice for the current COVID pandemic. The first point is essentially incontrovertible. Who can argue that metabolic dysfunction is behind virtually every single chronic disease we face today from diabetes to heart disease, to stroke to Alzheimer's?
Jul 30, 2020 4 tweets 1 min read
The notion that we need plant fiber for a "healthy" microbiome is fundamentally incorrect. Adding fiber to the diet doesn't increase alpha-diversity and removing it doesn't lead to a decrease in this metric. Think you need fiber for a healthy gut? Think again. These are my @onegevity results after 2 years on a nose to tail carnivore diet. Image