Discover and read the best of Twitter Threads about #2DG

Most recents (7)

So Dr. Reddy's has revealed the actual primary end point of their Phase 3 #2DG trial. They claim this was pre-specified and I guess we'll have to take their word 4 it.

But, wait a minute.. what was the +ve outcome they presented to DCGI? Was it time to 2 point improvement? 1/n
Umm, this sounds very different - they presented only proportion of patients with 1 point improvement at Day 3. Which if u recheck the last tweet, wasn't even one of their secondary end points! 2/n
What happened to all the other endpoints? Time to 2-pt imp, Time to reach pt 4, Time to pt 0, Time to negative PCR? What happened to these patients on Day 5, Day 7, Day 14??
Where is the test for statistical significance? Note that there is ZERO relevance of stating the RRR.. 3/n
Read 12 tweets
I would be pleasantly surprised if this press briefing by @MoHFW_INDIA is led by @drharshvardhan or even a junior minister. Let's tune it at 1600 IST or 1130 BST or 0630 EDT
@PriyankaPulla @d_s_thakur @AnooBhu @rdivia @RemaNagarajan
Questions:
Will the Govt set up
1. A research team to urgently draw up a research protocol to study the causes/risk factors for #Mucormycosis?
2. A committee of national and international experts to draw up evidence-based clinical guidelines?
3. An expert group of statisticians and epidemiologists to estimate and report on the true number of cases of #COVID19 and #Covid #deaths?
Read 4 tweets
How is India under the leadership of PM Sri
@narendramodi
facing the Covid-19 challenge in 2021?

This detailed thread will give you an insight into work done by the PM with emphasis on K'taka

Here's what the govt has done on vaccination

#YoungIndiaWithPM
@Tejasvi_Surya

1/n
Vaccination • #PMCares procured 66 million doses of COVID vaccines under Phase-I for Healthcare & Frontline Workers.

Our doctors are safe today because the PM ensured they get vaccinated on priority & VIP Culture in the country is shunned.

@MoHFW_INDIA

#YoungIndiaWithPM

2/n
Vaccination • Karnataka has administered over 87L first doses & over 25L second doses to beneficiaries

There are 5,308 vaccine sites in the state with 97.5% of them being government sites where vaccination is provided free of cost

@DHFWKA

#YoungIndiaWithPM

3/n
Read 22 tweets
.@DRDO_India द्वारा विकसित दवा 2-DG अब अस्पतालों में उपलब्ध होगी, जो मरीजों को कोरोना के खिलाफ़ लड़ाई लड़ने में अहम हथियार साबित होगी। आज मैंने रक्षा मंत्री श्री @rajnathsingh जी के साथ इस दवा को लॉन्च किया।

@PMOIndia @MoHFW_INDIA #Unite2FightCorona
अभी इस दवाई का सप्ताह में 10,000 के आसपास कुल उत्पादन होगा। आज #AIIMS, #AFMS और @DRDO_India के अस्पतालों को यह दवा उपलब्ध करायी गयी है। बाकी राज्यों को अगले चरण में #2DGMedicine दवा उपलब्ध करायी जाएगी।।

@PMOIndia @MoHFW_INDIA #Unite2FightCorona
#COVID19 के इलाज़ में सहायक #2DGMedicine की लॉन्चिंग के अवसर पर मैंने कहा कि आज का दिन हम सबके लिए सबसे ज़्यादा सुखद दिन है। ये हमारी पहली स्वदेशी दवा है, जो वैज्ञानिक दृष्टिकोण से COVID वायरस के प्रकोप को कम करने की पूरी क्षमता रखती है।@DRDO_India @rajnathsingh @PMOIndia #2DG
Read 7 tweets
1
Im quoted in report on #2DG, drug by #DRDO, marketd by #DRreddys 4 #CovidIndia. Issues R well highlightd by @neutranino in @the_hindu 'Repurposed' use is questionable
This 'approval' doesnt bring ray of hope, but doubts on drug regulation in #india
A🧵
thehindu.com/news/national/…
2
#2deoxy2glucose is basically glucose molecule in wich 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis (which is the metabolic pathway that converts glucose to pyruvate and a hydrogen ion, during which, the free energy released in process...
3...is used to form high-energy molecules such as ATP or NADH that helps in various cell functions). So basically, by using 2DG, the normal glycolysis doesnt happen and cell functions get blocked. This is the reason it is used for cancers
Cancer cells depend heavily on glucose...
Read 11 tweets
Now as everyone is talking about #2DG that is made by @DRDO_India, some people are also claiming that the hypothesis was first put forward by #Patanjali. Here is my take on the paper by #Patanjali (1/6)

@Neurophysik @GorwayGlobal @drabbyphilips @ForBetterSci
In this work, #2DG is docked with key viral proteins such as viral spike glycoprotein S2, viral NSP15 endoribonuclease, and protease 3CLpro. Other in-silico parameters like drug likeliness, bioactivity indices, and ADMETox have also been studied to generate supportive data. (2/6)
First of all, this is an in-silico paper and not an in-vitro paper or a RCT. That itself means that everything written in it is plain speculation. Secondly, the paper is still on a #Preprint server @authorea which means that it has not been peer-reviewed. (3/6)
Read 6 tweets
Developed by the Institute of Nuclear Medicine Allied Sciences, a lab of DRDO, in collaboration with @drreddys this new drug called #2DG (2-deoxy-D-glucose) helps #Covid19 patients recover faster & also reduces their dependence on oxygen

news18.com/news/india/how…
Reports claim that this drug selectively accumulates in infected cells and cuts off the energy supply to the virus

Therefore, the virus cannot multiply automatically, which helps in reducing the infection and the viral load gradually
1/1 DGCI which has given emergency approval has to show trial data

Here are few articles I could find on usage of #2DG in #covid19

tandfonline.com/doi/full/10.10…
Read 5 tweets

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