Rather than framing long COVID as a simple state of persistent systemic inflammation, this new study points toward a model of chronically dysregulated immunity in which NK-cell dysfunction may occupy a central mechanistic role🧵
This paper says something important. In at least a subset of patients, long COVID may represent a state of impaired, inefficient, and partly exhausted immune surveillance, with NK cells at its center.
The authors support this with three layers of evidence. SARS-CoV-2 antibodies persist in the blood, while key cytokines fall, NK/NKT cells are reduced in number, and the NK cells that remain carry transcriptional signatures of functional remodeling and suppression.
Måndagsrörelsens möte #201 på ett Norrmalmstorg i solsken (på husfasaderna), leddes av Fredrik Malm och Gunnar Hökmark.
Det är lätt att Mellanöstern tar allt fokus nu, men vi glömmer inte och blundar inte för krigsbrotten i Ukraina. Rättvisan måste till slut ha sin gång.
Under 3 dagars krig vid Persiska viken har fler Patriot/PAC-3 avfyrats mot ballistiska missiler än Ukraina avfyrat under 4 månaders ryska angrepp. Vi måste fortsätta stärka Ukrainas luftvärn.
Zelenskyj erbjuder nu hjälp till regionen mot de iranska Shaheddrönarna.
Kanadas nya ambassadör Robert Sinclair påminde om att de var första västland att erkänna Ukrainas självständighet 1991.
Kanada har gett 25 miljarder dollar i stöd till Ukraina sedan 2022.
Vi behöver gemensamt bygga vår säkerhet i den nya värld vi nu har som Carney sa i Davos.
Here are five things "I think" with the Seahawks as the negotiating window opens.
These have a chance to look silly over the next few days, so feel free to throw them back in my face if they're wrong (not that you would have waited for an invitation to do so).
Here we go ...
1) Of the Seahawks' top six UFAs, I think Josh Jobe has the best chance of re-signing. He had some of the best coverage numbers of any corner last season (see timeline). A self-made guy who seems to have the mindset/approach they want. My guess: he's back for around $10M/year.
2) Of the six – Jobe, Ken Walker III, Rashid Shaheed, Coby Bryant, Riq Woolen, Boye Mafe – I think there’s a chance only Jobe is back. Seattle has a good amount of cap space, but I don’t think they’ll make undisciplined, shortsighted moves to keep their Super Bowl roster intact.
Voy a intentar desarrollar esto. Evidentemente a EEUU le interesaría destruir Irán. El control pleno de Oriente Medio sería un avance en el control de los mercados de energía, que a su vez permite preservar la hegemonía del dólar, lo cual es indispensable para EEUU
Hay un vínculo interno entre la viabilidad de la hiperendeudada e hiperfinanciarizada economía norteamericana, la hegemonía del dólar, su supremacía militar y su grado de control sobre Oriente Medio y sus reservas de petróleo.
La fortaleza de la alianza con Israel reside en última instancia aquí, mucho más que en la fuerza del lobby sionista, que es un subproducto de lo anterior.
Acabar con Irán y sus aliados regionales implicaría acabar con toda fuerza de oposición relevante
A couple days ago I wrote about the first lever Iran holds in this war: the Strait of Hormuz. If Iran disrupts shipping through that narrow channel between Iran and Oman, roughly one-fifth of the world’s oil supply gets caught in the crossfire. Oil spikes. Shipping markets panic. The global economy starts sweating. That’s leverage.
But Hormuz is only half the story. Because there’s another vulnerability sitting right across the Persian Gulf—one that almost nobody outside the region knows about.
The modern cities of the Gulf are built in the middle of a motherfucking desert. Dubai. Abu Dhabi. Doha. Kuwait City. Manama.
Like this kind of desert!!!
Cities like these couldn’t exist before modern infrastructure. They exist because massive industrial plants along the coast turn seawater, the only water there, into drinking water. Take those machines away, and the system holding these cities together starts to break down frighteningly fast. Which means that in a regional war, those machines become something else entirely: targets.
II Cette note reprend des éléments de mon #Thread de samedi et d'une note plus ancienne.
Le modèle du choc a été réalisé avec des chercheurs russes
La note est actualisée à aujourd'hui - matin fpop.media/consequences-e…
III Elle analyse les conséquences sur la croissance des pays de l'UE (l'Allemagne, au pire, passe de +1,1 à -0,6% de croissance) et la France de 1% à 0,5% avec une hausse du déficit jusqu'à 5,5% du PIB
Ce sont des estimations médianes dans chaque cas. fpop.media/consequences-e…
Como muitos aqui já sabem, eu não sou jornalista - sou engenheiro.
Mas aparentemente preciso ensinar o bê-a-bá do jornalismo para o @eduguim , autor da matéria na Brasil 247 entitulado "Contrato de R$ 129 milhões da mulher de Moraes não existe".
Vem no 🧶:
1. Ele começa a matéria dizendo "a análise séria dos fatos verificáveis sobre essa denúncia mostra que o que predomina não são provas concretas"
2. Depois diz que não há contrato, escritura pública, instrumento jurídico original ou cópia autenticada com assinaturas reconhecidas das partes (me lembrei do Pedro Pedreira da Escolinha do Prof. Raimundo)
I have written extensively about Jared Kushner & how he has taken over the Epstein operation. With more info that keeps being revealed it is clear Jared has also taken control of the presidency. This FBI document is only one small piece of his role. Read each page of this thread.
“Josh Kushner & Jared Kushner were both his students. Dershowitz told CHS that if he were young again, he would be holding a stun gun as an Israeli Intelligence (Mossad) agent. CHS believed Dershowitz was co-opted by Mossad & subscribed to their mission.” Read the entire page1/3
“Chabad is doing everything they can to co-opt the Trump presidency.”
“Kushner has moved a lot of Russian investment money around.”
“Trump has been compromised by Israel, and Kushner is the real brains behind his organization and his presidency”.
Read the entire page ⬇️
L’IA peut maintenant analyser le marché des options comme les traders professionnels de Wall Street.
Certains utilisent déjà Claude ou ChatGPT pour automatiser leurs analyses et générer des revenus quotidiens avec les options.
Voici 12 prompts puissants inspirés des stratégies des grandes firmes de trading.
[ Ajoutez en signet 🔖pour ne pas perdre ! ]
1.Scanner de trades 0DTE
Prompt :
Agis comme un trader senior spécialisé dans les options 0DTE sur le S&P 500.
Analyse le marché actuel et génère :
• un credit spread put
• un credit spread call
• ou un iron condor
Inclure :
→ strikes exacts
→ profit maximum
→ perte maximale
→ timing d’entrée
→ règles de stop loss
2.Analyse du régime de marché
Prompt :
Agis comme un stratège quantitatif.
Classe le marché actuel selon :
• niveau du VIX
• tendance du marché
• volatilité implicite vs réelle
• calendrier économique
Puis indique si la stratégie doit être :
- vendre agressivement des options
- vendre prudemment
- rester en cash
🧵 8 pontos pra se prestar bastante atenção da coletiva de Eduardo Domínguez pós-clássico
1) “Eu não vou buscar desculpas nos jogadores. Seguramente me equivoquei na escalação, na estratégia, nas alterações. Perdemos em uma coisa que tenho muito clara: temos que nos preparar melhor. Hoje, não jogamos como se fosse uma final. Isso, sim, se notou. Falei no vestiário, não tenho problema em dizer. Temos que nos preparar melhor, senão vai ser difícil. Vamos ter que fazer trocas para quarta, porque não é o que buscamos. Temos que dar a cara. Quem não corre, não vai jogar. Hoje, correram mais. Não necessitamos dos dados de GPS. Se viu.”
2) Dificuldade para atacar o Cruzeiro
“Se o rival corre mais, sempre chega antes. Hoje, não se joga mais com técnica, com nomes. Há que se esforçar mais, nos está custando isso - não dessa semana. Então, temos que trabalhar. Deixar de falar, trabalhar, fazer, mostrar a cara.”
3) Como mudar o mental, tendo em vista finais perdidas
“Trabalhando. Não colocando desculpas. Não olhar para o costado. Mirar para o espelho, o que nos falta, o que pode fazer melhor.”
In Sept 2023, geophysicists over the world started monitoring an odd signal coming from the ground under them.
It was recorded in the Arctic, then Antarctica - then everywhere, every 90 seconds, regular as a metronome - for NINE DAYS.
What the HELL?
1/
In seismology, this is a USO: an Unidentified Seismic Object.
Perhaps if this discovery had leaked into mainstream news as quickly as potential alien biosignatures tend to do, we’d currently be seeing a big comeback for the HOLLOW EARTH ‘theory’.
Thankfully not the case!
2/
Instead, in the best collaborative tradition of modern science, researchers across the globe - 68 scientists from 40 institutions in 15 countries - joined forces to track down the signal’s source.
You don't need a USA / Canadian / Australian / German Citizenship to land remote work opportunities!
Check out these 14 sites that pay in USD worldwide.
1) FlexJobs:
FlexJobs is the top site for finding remote, hybrid, and flexible jobs. It offers hand-screened listings, ensuring no ads, scams, or junk. Perfect for anyone seeking a legitimate work-from-home opportunity
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How did a company from Shenzhen come to dominate Africa's cell phone industry?
It accepts African markets as they are, not as it wishes they were.
While some companies enter African markets with capital intensive Silicon Valley-style 'blitzscaling' approaches, China's Transsion entered the continent with a 'deep-plowing' strategy
What's 'deep plowing'?
An intensive, long-term approach of cultivating land to grow crops.
For Transsion, 'deep plowing' means starting from the bottom up with the most underserved customers, building extensive distribution networks, localizing products significantly, and investing in consumer trust to cultivate long-term market dominance:
• Customer 'deep plowing' — While competitors focused on premium urban consumers, Transsion targeted lower-income and underserved users, especially those in rural & peri-urban areas.
• Distribution 'deep plowing' — Transsion embeds itself in the informal retail networks that dominate electronic sales on the continent, employing thousands of agents to reach places competitors don't and establishing physical retail depth from factory to final sale.
• Product 'deep plowing' — Transsion went beyond superficial adaptation, spent years studying local needs & behaviors, and modified hardware and software accordingly, including pioneering multi-SIM phones in African markets.
• Service 'deep plowing' — One of Transsion's deepest 'plows' is its investment in after-sales service. While many electronics have no official repair centers locally, Transsion established the Carlcare network, Africa's largest mobile after-sales service network.
• Brand 'deep plowing' — Transsion created a brand ladder to cover the entire income spectrum: ultra-budget itel devices, performance-focused Infinixes, and aspirational Techno phones. This allows the company to capture customers as their incomes grow, instead of losing them to competitors.
Transsion didn't win Africa's cell phone market by building for the Africa of tomorrow.
They won by 'deep plowing' for the Africa that exists today.
h/t @lumiao1026 whose research on Transsion informs this post — check out the links below 👇🏽
Watch @lumiao1026 discuss Transsion's approach in Africa with @eric_olander on the @ChinaGSProject podcast
Then get @lumiao1026's new book 'The Transsion Approach: Translating Chinese Mobile Technology in Africa'
🚨 BREAKING: Designers are about to get replaced by prompts.
Claude Opus 4.6 can now build logos and design.
No big team.
No expensive tools.
Just the right prompts.
I tested this on real projects.
Here are 10 prompts that can create Apple-level logos for free 👇
When I started building small projects, I had one big problem:
Logos were expensive.
Designers charged $100–$1000.
Design tools were complicated.
So I tried something different…
I gave Claude very specific prompts.
And the results were shockingly good.
Here’s exactly how anyone can do it.
1️. The Brand Discovery Prompt
Start here. Claude needs to understand your brand first.
Prompt:
"Act as a world-class brand strategist.
Ask me 10 questions to understand my startup’s mission, audience, personality, and positioning so you can design the perfect logo."
In his second term alone, Trump has already canceled $1.5 billion of criminal debt — payments fraudsters owe the federal government and victims.
They don't mind debt cancellation—for themselves.
Trump’s own US attorney announced Joseph Schwartz’s 3yr sentence for $38M in medicaid/tax fraud.
7 months later, Trump pardoned him.
Schwartz paid a lobbyist $100,000+ to help secure a pardon from Trump and walked free with his debts owed to the federal government cancelled.
Republican Nevada legislator Michele Fiore embezzled $70,000 out of a police memorial fund for personal expenses like plastic surgery and her daughter's wedding.
After being convicted on 6 counts of wire fraud, Trump pardoned her.