Durante o fim de semana, um cientista tomou uma decisão que diz muito sobre o futuro da humanidade mas que acabou passando despercebida
Hoje, essa decisão derrubou em mais de 6% as ações da terceira maior empresa do mundo
Essa é a história do Nobel da Química que decidiu ir embora do Google e por que ela é importante para o seu futuro, para o meu futuro, para o nosso futuro
John Jumper é um cientista americano. Ele ganhou o prêmio Nobel da Química em 2024 por causa do AlphaFold
Uma inteligência artificial que resolveu um problema que assombrava os biólogos por mais de 50 anos: prever a estrutura tridimensional de proteínas e outras moléculas
Muitos afirmam que o AlphaFold é a coisa mais útil que a IA já desenvolveu até agora
Ele trabalhava com outro ganhador do mesmo Nobel, Demis Hassabis, no laboratório de IA da Google: o DeepMind
Na sexta-feira, Jumper anunciou que estava saindo da Google e indo para a Anthropic, empresa desenvolvedora do Claude e que lidera nesse momento a corrida da IA
"Mas HOC, o que uma troca de emprego de um cara que eu nunca ouvi falar muda na minha vida?" Continua aqui que vou explicar
Scotia Bank Canada was emailing sensitive banking information for one of its customers in Canada, to me, for almost a year. When it first started happening last year around August, I called the customer service line for BNS Ja and was advised to write an email to my home branch.
I did and nothing happened.
In March of this year the emails got more numerous and more and more sensitive. I'm talking links to secured loan transactions for document signs offs and deposit alerts. I was shocked just how much info I was getting on this person i didn't know.
the only thing we had in common, we shared a last name and first initial. I have been using my email with the bank for close to 20 years. This person just opened an account. How could this be happening?
1/ The Russian warblogger 'Fighterbomber', a retired Russian air force pilot, is taking heavy flak from other warbloggers for disclosing a fuel delivery to Crimea that the Ukrainians promptly blew up. "Go fuck yourself. Preferably holding hands," he responds. ⬇️
2/ On 17 June, in an apparent attempt to refute widespread accounts of fuel shortages in Crimea, 'Fighterbomber' wrote on his Telegram channel: "The audience is saying that fuel has arrived in Crimea. Lots of it. There's more coming. 😍"
3/ Three days later, Ukrainian forces struck the Kerch oil terminal's fuel depot, causing a major fire. An official Ukrainian Telegram channel trolled Fighterbomber by crediting the warblogger for the strike (it's unlikely that he had any influence on it).
Ce jeudi 25 juin, c'est... CONSEIL MUNICIPAL DE LYON 🥳😓🎉❤️
Outre la température qui peut vite monter dans la salle du conseil, en période caniculaire, l'ambiance sera lourde des conséquences récentes de l'affaire Abreu, qui a dynamité Cœur Lyonnais.
Et, en introduction de ce conseil municipal, il faudra revoter pour les Grands Electeurs en vue des Sénatoriales, à cause de grosses boulettes dans la constitution des listes de droite (allez en lire la liste, c'est rigolo)
Bolton: Damage to Iran's military infrastructure is real, but the regime stays and this deal is a significant political defeat.
Trump wanted the strait open to get gasoline prices down before November. He lost sight of the strategic issues that should have been central. 1/
Bolton: Gulf Arabs will live in fear that Tehran turns the strait on and off like a light switch.
Friends around the world wonder even more what an American commitment means. If we had taken military control of the strait at the outset, none of this would have happened. 2/
Bolton on the $300B fund Trump says the US won't pay for, the MOU says the US undertakes to create this fund "while ensuring financing of at least $300 billion."
That is a guarantee, and the US is the guarantor. If the Saudis and Emirates won't pay, it comes from us. 3X
Shilajit is NOT a Testosterone booster, it is a mitochondrial enhancer, which is where it truly shines.
1g in morning = amazing workout + brain energy
but why?
THREAD🧵
DBPs in Shilajit (and why they're so interesting)
Most people talk about how Shilajit contains a lot of trace minerals and Fulvic acid.
But the most interesting compounds that can be found in Shilajit are the DBPs, which are also known as:
Dibenzo-alpha-pyrones
let me explain👇
Why are these DBPs so beneficial?
there are 3 big reasons
(boring science warning)
NUMBER ONE:
they're 'Quinone-like' compounds
DBPs are technically not Quinones, because they do not have the structure of a Quinone (their core structure is a fused tricyclic lactone and not a cyclic dione)
But they act like quinones in redox reactions, electron transport, and mitochondrial function due to how they cycle between three redox states (reduced, semiquinone radical, and oxidized/quinone-like forms).
Accepting electrons from Complex I and II → then carrying those electrons to Complex III → in Complex III the electrons are donated and carried to Complex IV where the electrons are handed off to Oxygen preventing electrons to accumulate at Complex III and excess ROS to be produced
NUMBER TWO:
They work in tandem with CoQ10
CoQ10 shuttles electrons between Complex I/II & III but can be easily oxidized back from Ubiquinol (active CoQ10) back into Ubiquinon (oxidized form) under stress.
DBPs prevent the oxidation of Ubiquinol into Ubiquinon, and keep CoQ10 in its reduced form, protecting it from oxidative stress.
What does this mean?
Ubiquinol stays active for a longer time duration in the ETC (electron transport chain) causing less electron leakage and increased ATP production
↓
Ubiquinol is kept in the reduced form and its ability to neutralize free radicals is extended because of how Ubiquinol acts as antioxidant
↓
Mitochondrial membrane potential is now better preserved
↓
Energy production stays stable and efficient under stress, heavy exercise or even prolonged period of focus and attention
↓
Can handle more exercise, more work and even more emotional stress
(more on how Shilajit/DBPs enhance brain energy through improved mitochondrial function of the PFC later in this thread)
NUMBER THREE:
Mitophagy benefits of DBPs
Mitophagy is the process where your cells detect/recycle damaged/dysfunctional mitochondria through autophagy which prevents excessive ROS/oxidative stress and ensures that inefficient mitochondria are cleared away, keeping energy production efficient.
This helps to prevent fast aging, low energy and diseases.
So how does Shialjit enhance mitophagy through DBPs?
One of the primary DBPs in Shilajit is:
‘3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one’
this DBP is chemically similar to Urolithin A
It stabilizes PINK1 on damaged mitochondria, which then helps to recruit ‘Parkin” which then makes the mitochondria a visible target for mitophagy by attaching ubiquitin chains to the many proteins that sit on the outer membrane of the mitochondria.
Goodbye Keir Starmer. Once described as “The walking embodiment of Human Rights Law”, he was elected as a sensible technocrat pledging to stem the tide of populism and ousted as a censorious technocrat unable to stem the tide of populism
En 1935, un científico compró un diente colosal en una botica de Hong Kong. Lo vendían como un hueso mágico de dragón, pero aquel hallazgo reveló al mundo que nuestros ancestros convivieron con una raza real de King Kong de tres metros. El Gigantopithecus. Tira del hilo 🧵👇🏽👇🏽👇🏽
Ralph von Koenigswald era un brillante paleoantropólogo alemán que buscaba restos humanos, pero al ver aquel enorme molar en el mostrador de la farmacia china, supo inmediatamente que no pertenecía a ningún animal conocido por la ciencia de su época.
Lo sorprendente es que la medicina tradicional china llevaba siglos triturando estos "dientes de dragón" para fabricar pócimas curativas. Sin saberlo, los boticarios estaban moliendo los restos fósiles de una criatura legendaria que dominó la selva durante miles de años.
Graham: If the Iran deal fails, Trump takes the Strait of Hormuz by force. The US will control it and charge a fee for all ships passing through.
He says he spent four and a half hours with Trump on Friday laying this out. Expand the Abraham Accords in 2026. 1/
Graham: New policy if diplomacy collapses — when Hezbollah attacks Israel, the US hits Iran directly.
Not the proxy. Iran itself. "If Iran tests control of the Strait of Hormuz by the United States, we will obliterate them." To the Iranians: that is the message. 2/
Graham: On the $300B fund he called "a Marshall Plan for Germany with the Nazis still in charge", he changed position.
If money comes from Sunni Arabs, not the West, it proves Iran changed. "Do you think Saudi Arabia will invest in a theocracy bent on destroying Sunni Islam?" 3/
Recommend Assembly find O42 moot (replace phrase that somehow went missing from 29-1) - Stated Clerk and CCB both say it's editorial and OC doesn't need to make a recommendation. Thanks to the Presbytery for noticing the omission.
Discussing O35 - deadline for an indictment, avoiding using the process as a punishment
Overture author make an amendment. Now would require indictment within 90 or charges must be dropped.
Substitute motion to answer in the negative.
Speech against the Overture - prompt process is important, but cases vary. One case took better than 6 months to write an indictment because of multiple reluctant witnesses. Presbyteries can create time limits when empowering a judicial commission.
I love the BBC. It gave me everything I have (well, them and ITN who have been amazing as well). But there is an internal civil war going on and this article tells you everything you need to know:
"... we apologise for the failures in our reporting."
"Update 17 June: This article was originally published without including key details about this case, due to miscommunication between BBC reporters in court and the writers. We have updated the article to explain that...
... these threats were directed at three all-girls' schools, related to the "misgendering" of trans girls and that Darren Rigby identified in one threat as a trans woman...
Judge McFadden DENIES the defense's motion to disqualify @USAttyPirro and @DAGToddBlanche from the case.
Defense had argued that Blanche and Pirro being at the scene of the alleged crime and publicly commenting on it had created a conflict.
The four main arguments were the following:
(1) Their presence at the WHCA Dinner made them witnesses (both reported hearing the gunshots)
(2) Their presence at the WHCA Dinner made them potential victims of Allen (according to the gov't's theory of the case), (both reported that they were in the “line of fire” and had to be evacuated)
(3) Blanche and Pirro's statements to media about the events at the WHCA Dinner were prejudicial and showed bias
(4) Citing the longtime friendship of Trump and Pirro, Trump being the alleged intended victim, and Pirro being the prosecutor, this created an appearance of impropriety. storage.courtlistener.com/recap/gov.usco…
Judge McFadden addresses argument (1)—Blanche and Pirro were witnesses.
"...whatever firsthand knowledge they have about Allen’s actions appears limited to what anyone in the ballroom would have..."
"...absent special circumstances, an attorney can “elect in which capacity [he] intend[s] to proceed, either as counsel or as a witness.” Because neither side indicates that it plans to call Blanche or Pirro as a witness, the advocate-witness rule poses no concerns."
El crecimiento económico de Venezuela se desaceleró a 2,5 por ciento interanual en el primer trimestre de 2026, según datos publicados recientemente por el BCV. Es la tasa de crecimiento más baja observada desde el segundo trimestre de 2021. Aquí va un 🧵.
En vista de estos resultados, no sorprende que los venezolanos sientan que las condiciones de vida no han comenzado a mejorar. Los resultados contrastan marcadamente con las afirmaciones del gobierno de Trump de que a los venezolanos les va mejor que nunca.
Primero, una advertencia: son cifras del primer trimestre de 2026. Pueden reflejar retrasos en la implementación del nuevo esquema petrolero con EE. UU. Cabría esperar que las cifras mejoren significativamente en el resto del año, incluido el segundo trimestre en curso.
1/ Dozens of specialist workers were likely killed or wounded in today's Ukrainian strike in Voronezh. Russian warbloggers are dismayed, complain that the Russian government is ignoring it, and call for London to be nuked in retaliation. ⬇️
2/ Heavy missiles (it's not yet clear what type; the Russian warbloggers assume a UK/French Storm Shadow or SCALP/ER) have caused heavy damage and raging fires at the Voronezh Semiconductor Devices Plant, a vital element of Russia's missile production chain.
3/ The regional governor says that five people are known to have died, with dozens more injured. He says that while most were able to take shelter and survived, many ignored the alert and were caught up in the attack.
۱/ خیلی در فضای مجازی پخش میشه دمای فلان شهر به این درجه سلسیوس رسید، یا دمای این منطقه رکورد جهانی زد یا از این دست خبرها که مخاطب زیادی جذب میکنه. اما جریان چیه؟ چه دماهایی در دنیا توسط سازمان جهانی هواشناسی (WMO) تایید شدهاند؟
۲/ ثبت دماهای عجیب همیشه به معنی رکورد جهانی نیست. سازمان جهانی هواشناسی بارها رکوردهای بزرگی مثل دمای ۵۸ درجه لیبی بعد از بررسی تیم فنی رد کرده، چون مشخص شده عواملی مثل خطای متصدی یا خرابی ادوات باعث ثبت غیر واقعی این اعداد بودن.
۳/ بر اساس جدول رکوردهای سازمان جهانی هواشناسی، بالاترین دمای رسمی و تایید شده تاریخ زمین ۵۶.۷ درجه سلسیوس در دره مرگ آمریکا (۱۹۱۳) هست. بر اساس جدول WMO، زیر رکوردهایی خط کشیده میشه که ارزیابی فنی و تایید نهایی شده باشند.