Most recent unrolls from @ThreadReaderApp

Mar 9
Rather than framing long COVID as a simple state of persistent systemic inflammation, this new study points toward a model of chronically dysregulated immunity in which NK-cell dysfunction may occupy a central mechanistic role🧵
This paper says something important. In at least a subset of patients, long COVID may represent a state of impaired, inefficient, and partly exhausted immune surveillance, with NK cells at its center.
The authors support this with three layers of evidence. SARS-CoV-2 antibodies persist in the blood, while key cytokines fall, NK/NKT cells are reduced in number, and the NK cells that remain carry transcriptional signatures of functional remodeling and suppression.
Read 25 tweets
Mar 9
Måndagsrörelsens möte #201 på ett Norrmalmstorg i solsken (på husfasaderna), leddes av Fredrik Malm och Gunnar Hökmark.
Det är lätt att Mellanöstern tar allt fokus nu, men vi glömmer inte och blundar inte för krigsbrotten i Ukraina. Rättvisan måste till slut ha sin gång. Image
Under 3 dagars krig vid Persiska viken har fler Patriot/PAC-3 avfyrats mot ballistiska missiler än Ukraina avfyrat under 4 månaders ryska angrepp. Vi måste fortsätta stärka Ukrainas luftvärn.
Zelenskyj erbjuder nu hjälp till regionen mot de iranska Shaheddrönarna. Image
Kanadas nya ambassadör Robert Sinclair påminde om att de var första västland att erkänna Ukrainas självständighet 1991.
Kanada har gett 25 miljarder dollar i stöd till Ukraina sedan 2022.
Vi behöver gemensamt bygga vår säkerhet i den nya värld vi nu har som Carney sa i Davos. Image
Read 8 tweets
Mar 9
Here are five things "I think" with the Seahawks as the negotiating window opens.

These have a chance to look silly over the next few days, so feel free to throw them back in my face if they're wrong (not that you would have waited for an invitation to do so).

Here we go ...
1) Of the Seahawks' top six UFAs, I think Josh Jobe has the best chance of re-signing. He had some of the best coverage numbers of any corner last season (see timeline). A self-made guy who seems to have the mindset/approach they want. My guess: he's back for around $10M/year.
2) Of the six – Jobe, Ken Walker III, Rashid Shaheed, Coby Bryant, Riq Woolen, Boye Mafe – I think there’s a chance only Jobe is back. Seattle has a good amount of cap space, but I don’t think they’ll make undisciplined, shortsighted moves to keep their Super Bowl roster intact.
Read 6 tweets
Mar 9
1. @KBtheYoungOG
Perhaps you should provide details of your medical qualifications, & experience of providing medical care to TP, before commenting

Sorry you made shite decisions but you could now Tell the truth

You admitted lying to Drs, to get PBs …
2. Then aged 18 you continued those lies in order to get testosterone & experience male puberty

You continued to lie in order to get chest reconstruction,

And then went, “oh shit, I made a huge mistake”

But instead of accepting that it was down to you, you now want to…
3. … blame everybody else & you want to stop all trans people receiving Treatment.

For over 98% of TP, who don’t lie to their health carers, the decisions made are correct

You claims are not supported by any people who are experts in providing healthcare to trans people, …
Read 6 tweets
Mar 9
Voy a intentar desarrollar esto. Evidentemente a EEUU le interesaría destruir Irán. El control pleno de Oriente Medio sería un avance en el control de los mercados de energía, que a su vez permite preservar la hegemonía del dólar, lo cual es indispensable para EEUU
Hay un vínculo interno entre la viabilidad de la hiperendeudada e hiperfinanciarizada economía norteamericana, la hegemonía del dólar, su supremacía militar y su grado de control sobre Oriente Medio y sus reservas de petróleo.
La fortaleza de la alianza con Israel reside en última instancia aquí, mucho más que en la fuerza del lobby sionista, que es un subproducto de lo anterior.
Acabar con Irán y sus aliados regionales implicaría acabar con toda fuerza de oposición relevante
Read 25 tweets
Mar 9
🚨🚨🚨Iran’s Other Leverage: WATER

A couple days ago I wrote about the first lever Iran holds in this war: the Strait of Hormuz. If Iran disrupts shipping through that narrow channel between Iran and Oman, roughly one-fifth of the world’s oil supply gets caught in the crossfire. Oil spikes. Shipping markets panic. The global economy starts sweating. That’s leverage.Image
But Hormuz is only half the story. Because there’s another vulnerability sitting right across the Persian Gulf—one that almost nobody outside the region knows about.

The modern cities of the Gulf are built in the middle of a motherfucking desert. Dubai. Abu Dhabi. Doha. Kuwait City. Manama.

Like this kind of desert!!!Image
Cities like these couldn’t exist before modern infrastructure. They exist because massive industrial plants along the coast turn seawater, the only water there, into drinking water. Take those machines away, and the system holding these cities together starts to break down frighteningly fast. Which means that in a regional war, those machines become something else entirely: targets.
Read 12 tweets
Mar 9
I. J'ai publié une longue note sur Fréquence Populaire Média sur les choc énergétique que la guerre contre l'Iran va engendrer

fpop.media/consequences-e…
II Cette note reprend des éléments de mon #Thread de samedi et d'une note plus ancienne.
Le modèle du choc a été réalisé avec des chercheurs russes
La note est actualisée à aujourd'hui - matin
fpop.media/consequences-e…
III Elle analyse les conséquences sur la croissance des pays de l'UE (l'Allemagne, au pire, passe de +1,1 à -0,6% de croissance) et la France de 1% à 0,5% avec une hausse du déficit jusqu'à 5,5% du PIB
Ce sont des estimations médianes dans chaque cas.
fpop.media/consequences-e…
Read 4 tweets
Mar 9
Como muitos aqui já sabem, eu não sou jornalista - sou engenheiro.

Mas aparentemente preciso ensinar o bê-a-bá do jornalismo para o @eduguim , autor da matéria na Brasil 247 entitulado "Contrato de R$ 129 milhões da mulher de Moraes não existe".

Vem no 🧶: Image
1. Ele começa a matéria dizendo "a análise séria dos fatos verificáveis sobre essa denúncia mostra que o que predomina não são provas concretas"
2. Depois diz que não há contrato, escritura pública, instrumento jurídico original ou cópia autenticada com assinaturas reconhecidas das partes (me lembrei do Pedro Pedreira da Escolinha do Prof. Raimundo)
Read 15 tweets
Mar 9
I have written extensively about Jared Kushner & how he has taken over the Epstein operation. With more info that keeps being revealed it is clear Jared has also taken control of the presidency. This FBI document is only one small piece of his role. Read each page of this thread. Image
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“Josh Kushner & Jared Kushner were both his students. Dershowitz told CHS that if he were young again, he would be holding a stun gun as an Israeli Intelligence (Mossad) agent. CHS believed Dershowitz was co-opted by Mossad & subscribed to their mission.” Read the entire page1/3 Image
“Chabad is doing everything they can to co-opt the Trump presidency.”
“Kushner has moved a lot of Russian investment money around.”
“Trump has been compromised by Israel, and Kushner is the real brains behind his organization and his presidency”.
Read the entire page ⬇️ Image
Read 4 tweets
Mar 9
L’IA peut maintenant analyser le marché des options comme les traders professionnels de Wall Street.

Certains utilisent déjà Claude ou ChatGPT pour automatiser leurs analyses et générer des revenus quotidiens avec les options.

Voici 12 prompts puissants inspirés des stratégies des grandes firmes de trading.

[ Ajoutez en signet 🔖pour ne pas perdre ! ]
1.Scanner de trades 0DTE

Prompt :

Agis comme un trader senior spécialisé dans les options 0DTE sur le S&P 500.

Analyse le marché actuel et génère :

• un credit spread put
• un credit spread call
• ou un iron condor
Inclure :
→ strikes exacts
→ profit maximum
→ perte maximale
→ timing d’entrée
→ règles de stop loss
2.Analyse du régime de marché

Prompt :

Agis comme un stratège quantitatif.

Classe le marché actuel selon :

• niveau du VIX
• tendance du marché
• volatilité implicite vs réelle
• calendrier économique
Puis indique si la stratégie doit être :
- vendre agressivement des options
- vendre prudemment
- rester en cash
Read 15 tweets
Mar 9
🧵 8 pontos pra se prestar bastante atenção da coletiva de Eduardo Domínguez pós-clássico

1) “Eu não vou buscar desculpas nos jogadores. Seguramente me equivoquei na escalação, na estratégia, nas alterações. Perdemos em uma coisa que tenho muito clara: temos que nos preparar melhor. Hoje, não jogamos como se fosse uma final. Isso, sim, se notou. Falei no vestiário, não tenho problema em dizer. Temos que nos preparar melhor, senão vai ser difícil. Vamos ter que fazer trocas para quarta, porque não é o que buscamos. Temos que dar a cara. Quem não corre, não vai jogar. Hoje, correram mais. Não necessitamos dos dados de GPS. Se viu.”
2) Dificuldade para atacar o Cruzeiro

“Se o rival corre mais, sempre chega antes. Hoje, não se joga mais com técnica, com nomes. Há que se esforçar mais, nos está custando isso - não dessa semana. Então, temos que trabalhar. Deixar de falar, trabalhar, fazer, mostrar a cara.”
3) Como mudar o mental, tendo em vista finais perdidas

“Trabalhando. Não colocando desculpas. Não olhar para o costado. Mirar para o espelho, o que nos falta, o que pode fazer melhor.”
Read 8 tweets
Mar 9
OK, this is nuts.

In Sept 2023, geophysicists over the world started monitoring an odd signal coming from the ground under them.

It was recorded in the Arctic, then Antarctica - then everywhere, every 90 seconds, regular as a metronome - for NINE DAYS.

What the HELL?

1/ Image
In seismology, this is a USO: an Unidentified Seismic Object.

Perhaps if this discovery had leaked into mainstream news as quickly as potential alien biosignatures tend to do, we’d currently be seeing a big comeback for the HOLLOW EARTH ‘theory’.

Thankfully not the case!

2/ Image
Instead, in the best collaborative tradition of modern science, researchers across the globe - 68 scientists from 40 institutions in 15 countries - joined forces to track down the signal’s source.

What they found was astonishing!

(Yes yes, I'm getting there.)

3/ Image
Read 11 tweets
Mar 9
You don't need a USA / Canadian / Australian / German Citizenship to land remote work opportunities!

Check out these 14 sites that pay in USD worldwide.
1) FlexJobs:

FlexJobs is the top site for finding remote, hybrid, and flexible jobs. It offers hand-screened listings, ensuring no ads, scams, or junk. Perfect for anyone seeking a legitimate work-from-home opportunity
2) We Work Remotely:

We Work Remotely is the largest remote work community, offering a wide range of remote job listings in various fields. Perfect for those seeking flexible work opportunities without geographic restrictions
Read 16 tweets
Mar 9
WE STILL DON'T HAVE A CLEAR ANSWER ON THE MOST BASIC QUESTION ABOUT THE IRAN WAR

WHY did the U.S. go to war?

A Popular Information review of public statements over the last 9 days found 17 DIFFERENT EXPLAINATIONS. Many of which contradict each other.

🧵
Here is a sampling:

1. Iran’s nuclear program was “obliterated” last June, but the U.S. started the war because Iran refused to abandon its “nuclear ambitions.”

popular.info/p/9-days-in-th…
2. Absent an attack, Iran would have had a nuclear weapon within two weeks. Image
Read 10 tweets
Mar 9
If I wanted to gain as much muscle as I possibly could in the next calendar year, here are the EXACT 12 things I would do:

1. STOP using nicotine

Nicotine restricts blood flow.

It's funny - the same bros who take Tadalafil for blood flow crush a can of Zyns per day.

AVOID.
2. Train 5 days per week

Three or four days doesn't cut it.
This is an all-out SPRINT.

Your body will adapt. You will gain more muscle training more frequently.

The low frequency bros have this one wrong.
3. Take 10 grams of creatine daily

It will improve your performance and recovery. Every little bit helps. Maybe 5 grams will cover your bases, but it's cheap, so why not.

Grab creatine monohydrate powder - no gummies or capsules or reason for "micronized" creatine.
Read 15 tweets
Mar 9
How did a company from Shenzhen come to dominate Africa's cell phone industry?

It accepts African markets as they are, not as it wishes they were.

While some companies enter African markets with capital intensive Silicon Valley-style 'blitzscaling' approaches, China's Transsion entered the continent with a 'deep-plowing' strategy

What's 'deep plowing'?

An intensive, long-term approach of cultivating land to grow crops.

For Transsion, 'deep plowing' means starting from the bottom up with the most underserved customers, building extensive distribution networks, localizing products significantly, and investing in consumer trust to cultivate long-term market dominance:

• Customer 'deep plowing' — While competitors focused on premium urban consumers, Transsion targeted lower-income and underserved users, especially those in rural & peri-urban areas.

• Distribution 'deep plowing' — Transsion embeds itself in the informal retail networks that dominate electronic sales on the continent, employing thousands of agents to reach places competitors don't and establishing physical retail depth from factory to final sale.

• Product 'deep plowing' — Transsion went beyond superficial adaptation, spent years studying local needs & behaviors, and modified hardware and software accordingly, including pioneering multi-SIM phones in African markets.

• Service 'deep plowing' — One of Transsion's deepest 'plows' is its investment in after-sales service. While many electronics have no official repair centers locally, Transsion established the Carlcare network, Africa's largest mobile after-sales service network.

• Brand 'deep plowing' — Transsion created a brand ladder to cover the entire income spectrum: ultra-budget itel devices, performance-focused Infinixes, and aspirational Techno phones. This allows the company to capture customers as their incomes grow, instead of losing them to competitors.

Transsion didn't win Africa's cell phone market by building for the Africa of tomorrow.

They won by 'deep plowing' for the Africa that exists today.

h/t @lumiao1026 whose research on Transsion informs this post — check out the links below 👇🏽
Watch @lumiao1026 discuss Transsion's approach in Africa with @eric_olander on the @ChinaGSProject podcast

Then get @lumiao1026's new book 'The Transsion Approach: Translating Chinese Mobile Technology in Africa'

amzn.to/40kvAxe
Read 4 tweets
Mar 9
Hay algo muy importante en la música, y es como titulas a un album.

Hay títulos memorables. Hay otros absurdos. Complejos hasta el absurdo o sencillos hasta la obviedad.

Y luego están los de Police.

Y os lo voy a contar en una pilldorilla improvisada de #LaHistorietaMusical. Fotografía promocional de los inicios de The Police, con Andy Summers con una camiseta morada sin tirantes haciendo el gesto de lavarse los dientes con un cepillo rojo gigante, Sting en medio con chaqueta deportiva negra sujetando una raqueta de tenis gigante y Stewart Copeland con camiseta a franjas horizontales amarillas negras y naranjas bajo un blazer azul sujetando lo que parece un torno de dentista también gigante. Discogs.
Vamos a desarrollar un poco lo que he empezado.

Porque ponerle título a un disco es una forma de llamar la atención sobre él pero también es toda una declaración de intenciones.

Por ejemplo puedes no ponerle titulo. O simplemente numerarlos, como los primeros de Led Zeppelin. Las portadas de los cuatro primeros discos de Led Zeppelin, numeradas simplemente del 1 al 4 en números romanos. La primera es una imagen del Zeppelin Hinderburg, la segunda, la tripulación retocada de la fuerza aérea alemana de la Primer Guerra Mundial, pero con las cabezas de miembros del grupo, equipo y amigos, la cuarta el nombre del grupo en una tipografía colorida y hippie y la cuarta la fotografía de un leñero acarreando leña. Discogs.
Puede ser solo algo descriptivo y sencillo, como llamar Grandes Éxitos a un disco de... pues eso.

O puedes elegir algo metafórico que exprese el sentido del disco.

La cara oscura de la luna. La estrella negra de David Bowie. Apetito por la destrucción. O un tipo de magia.
Read 16 tweets
Mar 9
🚨 BREAKING: Designers are about to get replaced by prompts.

Claude Opus 4.6 can now build logos and design.

No big team.
No expensive tools.
Just the right prompts.

I tested this on real projects.

Here are 10 prompts that can create Apple-level logos for free 👇 Image
When I started building small projects, I had one big problem:

Logos were expensive.
Designers charged $100–$1000.

Design tools were complicated.

So I tried something different…

I gave Claude very specific prompts.

And the results were shockingly good.

Here’s exactly how anyone can do it.
1️. The Brand Discovery Prompt

Start here. Claude needs to understand your brand first.
Prompt:

"Act as a world-class brand strategist.
Ask me 10 questions to understand my startup’s mission, audience, personality, and positioning so you can design the perfect logo."

This creates the foundation of the logo.
Read 14 tweets
Mar 9
Trump *is* doing debt cancellation.

It's just not your student or medical debts.

In his second term alone, Trump has already canceled $1.5 billion of criminal debt — payments fraudsters owe the federal government and victims.

They don't mind debt cancellation—for themselves.
Trump’s own US attorney announced Joseph Schwartz’s 3yr sentence for $38M in medicaid/tax fraud.

7 months later, Trump pardoned him.

Schwartz paid a lobbyist $100,000+ to help secure a pardon from Trump and walked free with his debts owed to the federal government cancelled.
Republican Nevada legislator Michele Fiore embezzled $70,000 out of a police memorial fund for personal expenses like plastic surgery and her daughter's wedding.

After being convicted on 6 counts of wire fraud, Trump pardoned her.
Read 9 tweets
Mar 9
❤️COMBAT AIR TEAMING SYSTEM

With GHATAK Program now looking much brighter ,and We are serious about India Stealth Strike UCAV

We still have failed to give importance to another same category of project --CATS WARRIOR

Which is capable of A2A/ A2G Roles both and economical

1/n Image
It's a Smaller Platform with the 2 PTAE-W Engine with 3.7 Kn Thrust each =7.4 kn total

But a Bigger similar Platform can be made with 25Kn HAL HTFE-25 kn engine

2/n Image
Image
Level 3 to 4 btw Autonomous functioning CATS operare at

3/n Image
Read 11 tweets
Mar 9
Oil Breaks Through $100 A Barrel & Mortgage Rates Go Up As 5 - Yr Canada Bond Yields Jump 9% In A Week

What to do if you are in the middle of purchasing a home or have a Mortgage Renewal in the next 3 months?

LOCK IN A RATE NOW!

There are a few low rates still around today

2/
But likely gone tomorrow or the next day

I have covered this story before

Oil price up = Inflation up = Canada Bond Yields up = Mortgage Rates up

But what about Variable, which has nothing to do with Bond Yields?

Variable is a Bank of Canada decision

What will BoC do?

3/
Nothing for now: NO CHANGE at the next BoC Announcement on March 18th

But what about the future?

It's 100% up to how long the War in the Middle East lasts

If it's over next week all good at BoC

If the War is still raging in June: Look Out

Rate Hikes be coming

4/
Read 6 tweets