Discover and read the best of Twitter Threads about #3rs
Most recents (2)
Over 70% of drugs that seem promising in animal studies fail when tested in humans. Organ-on-a-chip technology could radically change this picture. whatisbiotechnology.org/index.php/scie…
Designed with cells from the human body, as this series of tweets show #Organonachips have taken many decades to materialise, starting with John Syer Bristoe’s idea for an artificial organ in 1876 
The development of #Organonachip is rooted in the concept of the #3Rs (Reduce, Refine and Replace animal testing) first outlined in 1959 by William Russell and Rex Burch
I am very happy that @MKrzywinski and Naomi Altman gave us the opportunity to contribute an article on the #standardizationfallacy to their legendary #pointsofsignificance column in @naturemethods
nature.com/articles/s4159…
nature.com/articles/s4159…
It all started 20 (actually 21) years ago with this 👇correspondence on behaviour and the standardization fallacy in @NatureGenet nature.com/articles/ng110…
It was my response to this 👇famous paper in @ScienceMagazine by John Crabbe and colleagues showing that behavioural phenotypes of mouse mutants may turn out to be lab specific science.sciencemag.org/content/284/54…
