Discover and read the best of Twitter Threads about #4DNucleome
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(1/6) Excited to share that our OligoFISSEQ paper is up (nature.com/articles/s4159…)! We set out to develop single cell in situ #3Dgenome mapping methods. A fun collaborative effort led by @huy_sauce @ShyamtanuC and David Castillo, from @TingWu_Lab and @mamartirenom groups. 
(2/6) An idea that began with @SonCNguyen and Evan Daugharthy. The rest of the team including: @GuyNir5 @AntoniosLioutas @ElliotHershberg @Nuno_MCMartins @PaulReginato Mohammed Hannan @oligopain and @geochurch . Shout out to everyone @naturemethods for the great experience!
(3/6) To target and visualize genomic regions at genome-wide scale, we barcoded Oligopaints, increasing target capacity exponentially. We then visualize and map the targets by #InSituSequencing the barcodes using hybridization, synthesis, and ligation-based approaches.
