Discover and read the best of Twitter Threads about #AACR21
Most recents (1)
Today at #AACR21 I was honored to present results of the phase 3 CheckMate 816 neoadjuvant chemo-nivo lung cancer trial on behalf of all the colleagues, patients & families who made it possible. In this thread I will discuss why we did the study, results and next steps/ 
This study built on an investigator-initated trial @ChaftJamie @SmithImmunology, @JulieBrahmer, @dpardol1 and I (many others have continued this work with larger phase 2 trials) reported back in 2018
nejm.org/doi/10.1056/NE…
nejm.org/doi/10.1056/NE…
In that small trial (supported by @AACR @SU2C & @LUNGevity among others) 20 pts had their lung cancers removed at surgery after 2 doses of nivo. 11 tumors underwent major pathological response, treatment was well tolerated and nivo appeared to drive an anti-tumor immune response.
