Discover and read the best of Twitter Threads about #ACr22
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Autoinflammatory syndromes by Dr Dan Kastner at #ACR22 !
1️⃣FMF🏖️
🧬AR, pyrin mutation, evolutionary resistance to Y pestis
🌡️Fever 1-3 days
😣Peritonitis (severe)
🫁Pleurisy unilateral
✊Mono or oligoarthritis
2%-->Amyloidosis
⚕️ colchicine, anti IL1 💉
#MedTwitter #MedEd
1️⃣FMF🏖️
🧬AR, pyrin mutation, evolutionary resistance to Y pestis
🌡️Fever 1-3 days
😣Peritonitis (severe)
🫁Pleurisy unilateral
✊Mono or oligoarthritis
2%-->Amyloidosis
⚕️ colchicine, anti IL1 💉
#MedTwitter #MedEd
2️⃣TRAPS
No ethnic predisposition
🧬AD, TNGRSF1A- p55
🌡️Fever 4-6 weeks
😣Serositis
♨️Migratory rash proximal -->distal
💪fasciitis
👁️ conjunctivitis, periorbital edema
Amyloidosis occasionally
❌response to colchicine
⚕️Steorids ✅ anti IL1✅
No ethnic predisposition
🧬AD, TNGRSF1A- p55
🌡️Fever 4-6 weeks
😣Serositis
♨️Migratory rash proximal -->distal
💪fasciitis
👁️ conjunctivitis, periorbital edema
Amyloidosis occasionally
❌response to colchicine
⚕️Steorids ✅ anti IL1✅
3️⃣HIDS/MKD
Northern europeans
🌡️3-7 days
😣 Serositis
🦵✊Arthritis
♨️Diffuse MP rash
Cervical adenopathy
Aphthous ulcers
⚕️Canakinumab
Northern europeans
🌡️3-7 days
😣 Serositis
🦵✊Arthritis
♨️Diffuse MP rash
Cervical adenopathy
Aphthous ulcers
⚕️Canakinumab
Amplify your research group! @jeffsparks is a champion for @BrighamResearch Rheum research, follow him for #ACR22 highlights from the Brigham
#ACR22 social media talk, very meta 
Part 1️⃣: optimize your conference tweeting
If you're reading this you probably know all of this!
The first pro-tip was figure out the conference hashtag
The second? Engage with others in rheum
#ACR22
If you're reading this you probably know all of this!
The first pro-tip was figure out the conference hashtag
The second? Engage with others in rheum
#ACR22
What else?
👉amplify your group
👉amplify speakers and sessions of interest
👉amplify your colleagues so they will amplify you in turn
#ACR22
👉amplify your group
👉amplify speakers and sessions of interest
👉amplify your colleagues so they will amplify you in turn
#ACR22
#ACR22 infection (COVID) posters
Abs 0784 @CCalabreseDO
Cleveland Clinic breakthrough infections, including data on n=21 who received Evusheld
📌Publication here: pubmed.ncbi.nlm.nih.gov/35791921/
#ACR22
Cleveland Clinic breakthrough infections, including data on n=21 who received Evusheld
📌Publication here: pubmed.ncbi.nlm.nih.gov/35791921/
#ACR22
@CCalabreseDO Abs 0779 @CCalabreseDO
Experience with evusheld PrEP with IMID on BCDT at Cleveland Clinic
📌Publication here: pubmed.ncbi.nlm.nih.gov/36123015/
#ACR22
Experience with evusheld PrEP with IMID on BCDT at Cleveland Clinic
📌Publication here: pubmed.ncbi.nlm.nih.gov/36123015/
#ACR22
The EULAR e posters were tiny (bad) but speakers could zoom in and out (good)
That would have been nice for #IgniteTalks #ACR22
That would have been nice for #IgniteTalks #ACR22
The sound is adequate though. EULAR issue was that the sound was poor in their (smaller) poster tour stages #ACR22 #IgniteTalk
#ACR22 epidemiology posters
Abs 0700 @zach_wallace_md
💻Using NLP, ML algorithms to identify ANCA vasculitis cases
They also looked at the difference in performance metrics with/without filtering keywords
An explosion of NLP studies in rheum! #ACR22
💻Using NLP, ML algorithms to identify ANCA vasculitis cases
They also looked at the difference in performance metrics with/without filtering keywords
An explosion of NLP studies in rheum! #ACR22
@zach_wallace_md Abs 0732 Ho, et al. @JYazdanyMD @MilenaGianfran
💻Part of the explosion of NLP studies in rheum
Here the UCSF group aimed to capture VZV cases (differentiate from vaccination); and to capture active vs historical cases
See their diagrams explaining the steps!
#ACR22
💻Part of the explosion of NLP studies in rheum
Here the UCSF group aimed to capture VZV cases (differentiate from vaccination); and to capture active vs historical cases
See their diagrams explaining the steps!
#ACR22
We have learned quite quickly that a virtual ONLY poster hall mixed into a hybrid meeting doesn't work well.
Poor wifi and the crashing platform compound the problem
And if it's online ONLY, is that truly hybrid?
#ACR22
Poor wifi and the crashing platform compound the problem
And if it's online ONLY, is that truly hybrid?
#ACR22
This is not a complaint thread. I am hoping we can have discussion about what works/doesn't work, and what could be done next year for #ACR23
It goes without saying that an in-person poster hall is the most requested item on the wishlist for #ACR23
@GrantSchulert @Tuhina_Neogi
@GrantSchulert @Tuhina_Neogi
Biostatician @MikeLaValley8 @BU_BMC_Rheum presents a quick overview on how to appropriately interpret results from studies #ACR22
Of course this is not an exhaustive deep dive, but covers some common errors of interpretation
Of course this is not an exhaustive deep dive, but covers some common errors of interpretation
@MikeLaValley8 @BU_BMC_Rheum First, what is your research question? What is the question you are trying to answer with t he study?
👉Does this exposure CAUSE this outcome?
#ACR22
👉Does this exposure CAUSE this outcome?
#ACR22
@MikeLaValley8 @BU_BMC_Rheum What are common observational study designs and what are big issues to watch out for?
These are issues that can affect the validity of their results.
There are more potential issues within these study designs that is beyond the scope of this table
#ACR22
These are issues that can affect the validity of their results.
There are more potential issues within these study designs that is beyond the scope of this table
#ACR22
#ACR22 #ACR2022
12S129. Purple Peripheries: Vasculopathy VS Vasculitis
Philip Seo is awesome as always
The most common cause is Cardiovascular followed by Rheumatic
More commonly vasculopathy than Vasculitis
12S129. Purple Peripheries: Vasculopathy VS Vasculitis
Philip Seo is awesome as always
The most common cause is Cardiovascular followed by Rheumatic
More commonly vasculopathy than Vasculitis
#ACR2022 #ACR22
12S130. Rheumatology Secrets and Pearls
Dr John Stone, at his best
🎯RA may present with asymmetric arthritis
🎯AAV might present with migratory oligoarthritis, which is steroid responsive
🎯Only a quarter of RA patients go into remission during pregnancy
12S130. Rheumatology Secrets and Pearls
Dr John Stone, at his best
🎯RA may present with asymmetric arthritis
🎯AAV might present with migratory oligoarthritis, which is steroid responsive
🎯Only a quarter of RA patients go into remission during pregnancy
#ACR2022 #ACR22
12S130. Rheumatology Secrets and Pearls
Jason Kolfenbach, with his wonderful pearls
1. Vasculitis Pearls
🦪For Steroids ➡️ Less is more
🦪Be very careful in stopping Rx in AAV pts
🦪Don't give up on PLEX in suspected AAV Anti-GBM may have ANCA positivity.
12S130. Rheumatology Secrets and Pearls
Jason Kolfenbach, with his wonderful pearls
1. Vasculitis Pearls
🦪For Steroids ➡️ Less is more
🦪Be very careful in stopping Rx in AAV pts
🦪Don't give up on PLEX in suspected AAV Anti-GBM may have ANCA positivity.
Really enthused that some of the @rheum_covid #ILAR grant recipients could join us at this event tonight & talk about their work and their experiences
@panlarleague @aflarrheum
#ACR22
@panlarleague @aflarrheum
#ACR22
@rheum_covid @PanlarLeague @AFLARRheum Carolina Isnardi - Argentina
on behalf of the SAR-COVID registry
@gponsestel
#ACR22
on behalf of the SAR-COVID registry
@gponsestel
#ACR22
@rheum_covid @PanlarLeague @AFLARRheum @gponsestel The setup of the SAR-COVID registry in Argentina
@rheum_covid #ACR22
@rheum_covid #ACR22
.@philipcrobinson as the @rheum_covid chair of the steering committee thanking everyone for their contributions #ACR22
At the GRA gathering, @jyazdanymd gives an overview of what @rheum_covid has accomplished since March 2020
The theme is the power of global collaboration
#ACR22
The theme is the power of global collaboration
#ACR22
@JYazdanyMD @rheum_covid We've seen this slide many times but this is the final tally: >30k cases reported to @rheum_covid including the @eular registry
#ACR22
#ACR22
@JYazdanyMD @rheum_covid @eular 4 Major Contributions to Inform Patient Care and Policy
arising from work done by @rheum_covid
#ACR22
arising from work done by @rheum_covid
#ACR22
#ACR22 spondyloarthritis treatment oral abstract session
🌟Abs 0542 @sofiaramiro82
@official_asas @eular_org revised recommendations for axSpA management
#ACR22
@official_asas @eular_org revised recommendations for axSpA management
#ACR22
@sofiaramiro82 @Official_ASAS @eular_org Abs 0542
Key differences:
🔑added JAK inhibitors to bDMARD considerations
🔑specific EMM recs: monoclonal TNFi for uveitis, IBD; IL17i for PsO
🔑consider taper if in sustained remission
#ACR22
Key differences:
🔑added JAK inhibitors to bDMARD considerations
🔑specific EMM recs: monoclonal TNFi for uveitis, IBD; IL17i for PsO
🔑consider taper if in sustained remission
#ACR22
@BU_BMC_Rheum Abs 1912 @profdeepakkumar
❓Is altered facilitatory and inhibitory nociceptive functioning is related to lower physical activity in people with knee OA?
#ACR22
❓Is altered facilitatory and inhibitory nociceptive functioning is related to lower physical activity in people with knee OA?
#ACR22
Brooke McGinley (mentor @mikelavalley8) with @bu_bmc_rheum @tuhina_neogi
Identifying subgroups of pts undergoing knee replacement in #MOST
#ACR22
Identifying subgroups of pts undergoing knee replacement in #MOST
#ACR22
@MikeLaValley8 @BU_BMC_Rheum @Tuhina_Neogi 🔹In the US more than 640,000 knee replacements annually
🔹In the US estimated 10.2 billion in annual costs
🔹Knee osteoarthritis consists of different phenotypes often leading to a knee replacement outcome
#ACR22
🔹In the US estimated 10.2 billion in annual costs
🔹Knee osteoarthritis consists of different phenotypes often leading to a knee replacement outcome
#ACR22
@MikeLaValley8 @BU_BMC_Rheum @Tuhina_Neogi Purpose:
To cluster patients who have undergone knee replacement into SUBGROUPS according to demographic and clinical characteristics to develop PHENOTYPES for use in clinical management of knee #OA
#ACR22
To cluster patients who have undergone knee replacement into SUBGROUPS according to demographic and clinical characteristics to develop PHENOTYPES for use in clinical management of knee #OA
#ACR22
In the ortho/rehab oral session, which is really an #OA session we have former @bu_bmc_rheum postdoc @kosakuaoyagi now with his own lab at @utep
Presenting his work with @tuhina_neogi: trajectories of pain sensitization in knee OA
#ACR22
Presenting his work with @tuhina_neogi: trajectories of pain sensitization in knee OA
#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi What is central pain sensitization?
Altered CNS nociceptive signaling
👉It's present in ~30% of people with knee OA & contributes to the pain experience in OA
#ACR22
Altered CNS nociceptive signaling
👉It's present in ~30% of people with knee OA & contributes to the pain experience in OA
#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi There's a lot we don't understand about the pain experience in OA, or about central pain sensitization
📈Patterns in central pain sensitization over time may also vary and influence pain differently
#ACR22
📈Patterns in central pain sensitization over time may also vary and influence pain differently
#ACR22
.@DPatWCorrigan with #MOST data @kecostello @ProfCaraLewis @MikeLaValley8 @tuhina_neogi @patellaprof @BU_BMC_Rheum
oral in the LBP/ortho/rehab session
#ACR22
oral in the LBP/ortho/rehab session
#ACR22
@DPatWCorrigan @kecostello @ProfCaraLewis @MikeLaValley8 @Tuhina_Neogi @patellaprof @BU_BMC_Rheum Individuals with unilateral symptomatic knee OA commonly walk in a way that unloads their knee with OA
This unloading can relieve pain, but may shift the load in such a way to increase risk of OA in the contralateral knee
#ACR22
This unloading can relieve pain, but may shift the load in such a way to increase risk of OA in the contralateral knee
#ACR22
@DPatWCorrigan @kecostello @ProfCaraLewis @MikeLaValley8 @Tuhina_Neogi @patellaprof @BU_BMC_Rheum This study aimed to explore relations between *ground reaction force symmetry metrics* and *cartilage worsening in the contralateral knee* in persons with unilateral knee OA
#ACR22
#ACR22
About to start! I bet @joannamarco likes the 🐻 team from UCLA #ACR22 #ACRKnowledgeBowl
Happy bday to the peds rheum half of the team!
Happy bday to the peds rheum half of the team!
A category is called Poly want a cracker 🦜 and @joannamarco wants everyone to know she was responsible #ACR22 #ACRKnowledgebowl
#ACR22 #ACR2022
12S110. Plenary I - 0003
Rituximab versus Cyclophosphamide for the Treatment of Connective Tissue Disease Associated Interstitial Lung Disease (RECITAL): A Sub-group Analysis of a Multi-centre Randomised Controlled Trial
HOT OF THE PRESS
thelancet.com/journals/lanre…
12S110. Plenary I - 0003
Rituximab versus Cyclophosphamide for the Treatment of Connective Tissue Disease Associated Interstitial Lung Disease (RECITAL): A Sub-group Analysis of a Multi-centre Randomised Controlled Trial
HOT OF THE PRESS
thelancet.com/journals/lanre…
Highlighting again some #ICYMI excellent #gout #CPPD content from #GCAN2022
#ACR22
#ACR22
The #gout mega GWAS will be presented by @TonyMerriman2 *on behalf of a very large team* at the third plenary session
#ACR22
#ACR22
#ACR22 Spondyloarthritis posters
Abs 0382 McDermott, et al.
MGB study of new axSpA cohort (n=555) investigating dx delay
📌Dx delay in axSpA is well described:
#ACR22
MGB study of new axSpA cohort (n=555) investigating dx delay
📌Dx delay in axSpA is well described:
#ACR22
Abs 0382 cont'd
Mean dx delay in this study: 6.8+/-8.5 yrs (consistent with prior studies)
In terms of factors a/w longer dx delay, they included the social vulnerability index, derived from US census data. This part is pretty novel
#ACR22
Mean dx delay in this study: 6.8+/-8.5 yrs (consistent with prior studies)
In terms of factors a/w longer dx delay, they included the social vulnerability index, derived from US census data. This part is pretty novel
#ACR22
#ACR2022 #ACR22
12S102. Year in Review 👌🏻
1st to be discussed was the Gloria Trial
Glucocorticoids effective but safety an issue
12S102. Year in Review 👌🏻
1st to be discussed was the Gloria Trial
Glucocorticoids effective but safety an issue
