Discover and read the best of Twitter Threads about #ADC
Most recents (6)
The #AACR23 abstracts will be accessible from here (not all sessions populated yet at the time of this tweet)
abstractsonline.com/pp8/#!/10828/
abstractsonline.com/pp8/#!/10828/
"new drugs on the horizon":
ND03 - Discovery of ARV-766, an androgen receptor degrading PROTAC for the treatment of men with metastatic castration resistant prostate cancer $ARVN #PROTAC
abstractsonline.com/pp8/#!/10828/p…
ND03 - Discovery of ARV-766, an androgen receptor degrading PROTAC for the treatment of men with metastatic castration resistant prostate cancer $ARVN #PROTAC
abstractsonline.com/pp8/#!/10828/p…
ND01 - ABBV-319: A first-in-class Glucocorticoid Receptor Modulator (GRM) agonist #ADC for the treatment of B-cell malignancies $ABBV
abstractsonline.com/pp8/#!/10828/p…
abstractsonline.com/pp8/#!/10828/p…
Happy to share our work: Membranous NECTIN-4 expression frequently decreases during metastatic spread of urothelial carcinoma and is associated with enfortumab vedotin resistance @CCR_AACR aacrjournals.org/clincancerres/… Follow our tweetorial about this clinically important data 1/12
First of all, a big thanks to @CCR_AACR for publishing our work! And thanks to all our cooperation partners! Especially @Markuseckstein3, @damian_ralser, @HolzelMichael, @IEO_HolzelLab, @UniklinikBonn 2/12
Intro: The #ADC enfortumab vedotin (EV) releases its cytotoxic agent into tumor cells via binding to the membrane receptor NECTIN-4. EV has been approved for patients with metastatic UC without prior assessment of the NECTIN-4 tumor receptor status by the FDA+EMA, because.. 3/12
At 23yrs Kingsley Moghalu was the legal officer at shell Nigeria.
At 28yrs he was training states military, police & judiciaries in Southeast Asia.
At 32yrs he was the political advisor to the UN electoral commission that negotiated peace between Serbia 🇷🇸 & Croatia.
…
At 28yrs he was training states military, police & judiciaries in Southeast Asia.
At 32yrs he was the political advisor to the UN electoral commission that negotiated peace between Serbia 🇷🇸 & Croatia.
…
34yrs old, Kingsley moghalu was representing Rwanda 🇷🇼 in UN international criminal tribunal. Along with security council where they tracked & prosecuted high-ranking members of Rwanda genocide.
38yrs old, head of global partnership team that managed $20 billion development
38yrs old, head of global partnership team that managed $20 billion development
finance and social investment funds that fought AIDS/Malaria (WHO)
At 41, became a Doctor of Philosophy (Ph.D) @ London school of economics & political science.
44yrs old, Highest ranking member at the UN (Director)
Wrote the book, The Politics of Global Justice while working
At 41, became a Doctor of Philosophy (Ph.D) @ London school of economics & political science.
44yrs old, Highest ranking member at the UN (Director)
Wrote the book, The Politics of Global Justice while working
As recently as 7/8 years ago, I would have reacted with disdain and disgust if you had suggested that I would ever enter the murky waters of Nigerian politics. But some things made me change my mind and to realize there’s no other place to make the real change we want happen.
First, I find the level of poverty in Nigeria heartbreaking. Why, I ask myself, should a country with so much potential be so poor? Answer: because it suffers from a lethal combination of incompetent governance, industrial scale corruption and willful mis-governance.
Sometime in 2017 I delivered a lecture at the Nigerian Institute of International Affairs in Lagos. After the lecture people surrounded me expressing appreciation for the insights the lecture gave them. But several people, including an old friend who was decidedly a university
As a young Political Affairs Officer @UN Headquarters in New York in the early 1990s I learnt the concept of "ripeness" in conflict resolution - that disputes are most effectively settled when the timing is ripe. The time is ripe in 2023 to defeat APCPDP and reclaim our country
for a better future for our children. The "film show" today in the so-called "major parties" that have made life in Nigeria a sad spectacle point to this fact. It's just left to us as citizens and voters to execute the country de grace and retire the failed, corrupt politicians.
A #ThirdForce can win in 2023 if Nigerians DECIDE to liberate themselves from failed politics and failed governance. It's as simple as #ADC
#KingsleyMoghalu
#Moghalu4President
#WhyMoghalu
#KingsleyMoghalu
#Moghalu4President
#WhyMoghalu
Surely every serious national security strategist understands the distinction btwn Govts Geopolitical decisions and th military's detailed scenario planning & action program. A govt can decided on basis of expected value of outcome or worst case scenarios-the latter is paralyzing
2/ns The critical issue in China-India conflict is that,as of now (2020), #China controls the #escalatory ladder. So India's #National #Security Apparatus has to make assumptions about when and how #CCPpla will escalate, if it loses the first few steps on its escalatory ladder!
3/ns The worst case scenario for us is therefore the one in which after loosing previous escalations, #CCP China escalates to a full fledged war/attack on India, by shifting US-facing troops and highest quality equipment towards India. This has proved paralyzing for past Govts!🤔
