Discover and read the best of Twitter Threads about #ADE

Most recents (24)

If you do want to read ONE paper/study this weekend, please go through this 🧵on an amazing work done by @BoytonRosemary @Daltmann10 & colleagues that has shaken the entire academic world! See the link👇 1/
When the process of developing new COVID19 vaccines started in 2020, the two threats to their success that most vaccine experts feared were: Antibody Driven Enhancement (ADE) and Original antigenic sin aka Antigenic Imprinting 2/

sciencedirect.com/science/articl…
Fortunately, the first immune phenomenon (#ADE) that had marred the reputation of one Dengue vaccine and few candidates ag RSV & others, is yet to be observed with current Covid vaccines. 3/
Read 21 tweets
Milkshake

Milk banks present the same troubling question that blood banks do, they aren't screening for spike protein or anti-spike antibodies. Recipients must assume donated milk is from a vaxxed woman.>
cbsnews.com/news/breast-mi…
If pharma companies wanted to eliminate the control group of unvaxxed children, formula shortages that motivate parents to feed infants the breast milk of vaxxed women, would be helpful.>
dailymail.co.uk/news/article-1…
"All of the milk samples were positive for IgG antibodies with a median of 12 BAU/mL...
About 89% of the milk samples had anti-SC2 spike protein IgA antibodies. IgG and IgA concentrations were higher in mothers breastfeeding beyond 23 mos compared to those breastfeeding less..">
Read 13 tweets
Il prof. #Broccolo su #COVID19: "Chi ha il booster si sente più sicuro, rispetta poco le regole. Poi quando gli anticorpi sono molto alti ci può essere l'effetto #ADE" a #dimartedì su @La7tv. Segue un thread un po' lungo ma spero semplificativo. Daje! 1/n 🧵
Chiunque abbia delle basi di immunologia o ci lavori o che l'abbia studiata durante il percorso di studi prenderà le distanze da tali dichiarazioni fuorvianti e inesatte. 2/n
Miliardi di dosi somministrate ma anche davanti all’evidenza c’è ancora chi mette in discussione la sicurezza dei vaccini anti-COVID. Ma con pazienza riprendiamo in mano alcuni principi basilari di immunologia. 3/n
Read 16 tweets
24) 22 January 2022 - Part 1: Children Vaccination

"This cannot be justified."
25) 22 January 2022 - Part 2 - 3: Booster and Omicron Booster

What's the story with Omicron-specific boosters and the risk of ADE - Antibody-Dependent Enhancement?
26) 11 February 2022 - Interview with Steve Kirsch

"When do they figure it out that they're making things worse?"

odysee.com/@VSRF:d/Dr-Gee…
Read 12 tweets
@GVDBossche @VerkerkRob @YouTube @RWMaloneMD @delbigtree 23) 30-Dec-2021 Interview with Michael McDowell

Omicron is not unexpected, "because it is highly infectious and that is what you would expect as a result of natural selection of a virus that is facing an increasingly high immune pressure from the population."
24) 22 January 2022 - Part 1: Children Vaccination

"This cannot be justified."
25) 22 January 2022 - Part 2 - 3: Booster and Omicron Booster

What's the story with Omicron-specific boosters and the risk of ADE - Antibody-Dependent Enhancement?
Read 8 tweets
🐈‍⬛What's New Pussycat🐈‍⬛

"Vaxxine-driven disease enhancement in animals vaxxinated against SARSCoV...is known to occur following viral challenge, and has been attributed to immune complexes and Fc-mediated viral capture by macrophages>
which augment T-cell activation and inflammation." newsvoice.se/2021/05/57-sci…
journals.asm.org/doi/10.1128/jv…
"To study the role of the FIPV SPIKE PROTEIN in early death, we immunized kittens with this recombinant vaxxinia virus. Subsequent challenge infection with FIPV resulted in markedly reduced survival times compared with those of control kittens...>
Read 6 tweets
01/ Vous voulez savoir :
- comment se protéger d’une #COVID sévère sans médicaments sur ordonnance ?
- pourquoi elle touche certaines personnes et pas d'autres ?
- ce qui cause les #EffetsSecondaires des #vaccins ?

#COVID_19 #covid19 #covid #coronavirus #vaccination

↓↓↓↓↓
02/ Jean-Marc Sabatier (@SabatierJeanMa1), Directeur de Recherche au CNRS depuis 32 ans, PhD/HDR en Biochimie et Microbiologie, nous explique tout cela dans une vidéo (crowdbunker.com/v/Mqr69rxT) dont je résume les 42 premières minutes dans ce #thread.
03/ Le virus #SARS-CoV-2 s’attaque au #SRA (le système rénine-angiotensine), un de nos systèmes de régulation les plus importants, responsable des fonctions autonomes rénales, pulmonaires, cardiovasculaires, de l’#immunité innée et du #microbiote intestinal.
Read 48 tweets
@Pmagazine #ADE
De burgers werden vanaf het begin BEDROGEN, het was een gekend risico waar het #EMA geen maatregelen trpf buiten testen op de beevolking. de eerste tekenen werden direct verdoezeld en eufemistisch #doorbraakinfecties genoemd!
ema.europa.eu/en/documents/r…
DIT 👇👇👇
@Pmagazine pag 135 van ema.europa.eu/en/documents/r…
" VAED .. door verschillende mechanismen:
* waarbij de #immuunrespons is #niet_volledig_beschermend en daardoor een ontstekingsreactie van het lichaam geeft, gevolg van
van het type immuunrespons met specifieke typen T-cellen,
of
@Pmagazine * #onvoldoende_sterke_antilichamen aan om SARS-CoV-2-infectie te voorkomen van cellen of produceert #zwakke_antilichamen die zich daadwerkelijk BINDEN AAN HET VIRUS EN HET HELPEN OM GEMAKKELIJKER DE CELLEN BINNEN TE DRINGEN #TROJAN_HORSE EN DE #ZIEKTE_VERERGEREN "
Read 4 tweets
'Ogni volta che valuta una terapia (#vaccino): e' sicura? funziona? ne hai bisogno?'. (dottor.Zelenko)
⬇️⬇️⬇️⬇️⬇️
#Zelenko
#trump
#Bolsonaro
#bambini
#COVID19
🔴🔴🔴🔴🔴

federicapicchi.eu/images/DR_ISRA…
Lo trovate qui se non lo rimuovono
🙄
Istoria Ministries Blog: Dr. Zelenko Speaks to Jerusalem Rabbinical Court
wadeburleson.org/2021/08/dr-zel…
Read 30 tweets
We zijn begonnen in de #raad020 De coronaindeling is voorbij. Na 1,5 jaar kan er weer normaal vergaderd worden. Welkom bij deze draad… Image
Meekijken kan ook op @SALTOamsterdam via deze link: salto.nl
@SALTOamsterdam Advocaat Nazmi Türkol is geinstalleerd als raadslid voor D66. Stond ook op de lijst voor de Tweede Kamer en schuift misschien door als D66 terugkomt in Rutte IV. Türkol is ook actief voor D66 in Nieuw West. #raad020
Read 36 tweets
Officiële tabel van #sciensano op basis waarvan zowel #Jambon als #DeCroo de niet gevaccineerden de hospitalen zien vullen!
In deze officiële tabel overheerst
"Vaccinatiestatus_onbekend", hoe trek je op basis van zo´n vehikel zo´n conclusie?
@waukema @AIustitiae @KAnthonissen
BOVENDIEN
Vanaf september 2021 zijn de ziekenhuizen PLOTS gestopt met de deelname ad ziekenhuissurveillance!!!
Waarom is dit , denkt u? #ADE?
De woorden "a pandemic of the unvaccinated" werden overal ter wereld simultaan gebruikt . Maar net zoals in België zijn de cijfers waarop deze uitspraak gebaseerd zijn heel MISLEIDEND!
In de US zijn deze cijfers van jan.'21 tem juni '21...
rumble.com/vl9h16-cdc-lie…
Read 8 tweets
#Covid19 Vaccination: What do we have learned so far?

It is almost 9 months since the first Covid vaccine was injected to a UK national.

Let’s do a quick recap of the major ‘takeaways’ in next 25 tweets......................
1) Covid vaccines are highly effective against severe disease, hospitalization, & deaths in fully vaccinated individuals. Studies after studies from different countries in different continents with different vaccines have confirmed this fact

ndm.ox.ac.uk/files/coronavi…
2) Vaccines have only minimal impact on infection and transmission. They are not able to halt/prevent development of a new surge. The current Covid19 vaccines are effective in preventing symptomatic COVID19 disease but fail to prevent SARS-CoV-2 infection
nature.com/articles/s4159…
Read 28 tweets
#Thread Les vaccins actuels [spike-vaccines], basés sur une forme modifiée de la protéine Spike du Coronavirus (et non sur le virus entier), pourraient empirer l’épidémie au lieu de la juguler, selon plusieurs études récentes. #ADE #DeltaPlus
Rappel : Après avoir été infecté par le SARS-CoV-2, l’organisme fabrique des anticorps contre le virus, notamment contre la protéine spike (qui permet au virus de se lier à l’organisme)

Spike est à la base des vaccins à ARN et des vaccins à adénovirus autorisés en UE et aux US.
Nos anticorps se répartissent en 3 catégories :

- Les anticorps qui n’ont aucun effet sur l’infection virale (anticorps neutres)

- Les anticorps qui bloquent l’infection virale (anticorps neutralisants)

- Les anticorps qui facilitent l’infection virale (anticorps facilitants)
Read 21 tweets
7/9/21: "CDC reports 'unprecedented' summer spike in respiratory virus"

7/26/21: "PHE has raised [] alarm after its surveillance programme, from samples taken by GPs & hospitals, found the positivity rate for #RSV had risen from 1.2%-8.9% in [] 5 weeks."

bbc.com/news/health-57…
Sept 9, 2020, Nature: "One potential hurdle for antibody-based #vaccines & #therapeutics is the risk of exacerbating #COVID19 severity via #ADE. ADE can increase the severity of multiple viral infections, including other respiratory viruses such as #RSV & measles." 👇
July 26, 2021: "Potential resurgence of respiratory syncytial virus in Canada"

"This may involve administering #RSV monoclonal antibody therapy in high-risk children off season, which is a major departure from standard practice."

#RSV

cmaj.ca/content/193/29…
Read 7 tweets
@werdendi Ko. sivu nyt myös arkistossa:
Tartuntatautirekisterin tilastotietokanta
archive.vn/ZRiab
@werdendi #Fimea @THLorg @STM_Uutiset @HUS_fi
Tartuntatautirekisterin tilastotietokanta: Raportointiryhmä 1,
#Covid19 - #koronavirus -infektiot: 2011/07 ja 2019/01.
- Miten ko. merkinnnät ovat syntyneet ja millä perusteella?
sampo.thl.fi/pivot/prod/fi/…
THL CC BY 4.0. 2021, Kuutio 03.08.2021
@werdendi @THLorg @STM_Uutiset @HUS_fi #Taiwan #CDC varoitti #WHO'ta email -kirjeellä:
- 'at least seven atypical #pneumonia, not #SARS' -tapauksista December 31, 2019, mutta THL'ssä rekisteröitiin #Covid19 -tapaus 8v. 5kk. aiemmin, 2011/07.
tinyurl.com/4z7h6vju
Read 12 tweets
The Disregard of #InformedConsent and Echoes of Nuremberg Part 2 - “The Great Pivot” - Jab hesitancy is informed, literate, and sophisticated, but government agencies, officials, and politicos pushed false narratives - by @TraderStef 4 #CrushTheStreet #ADE crushthestreet.com/articles/break… Image
I am moving "The Great Pivot & Echoes of Nuremberg Part 2" #InformedConsent2 (the thread from @RWMaloneMD's gracious RT ) to my acct original here. Replies were breaking apart/not keeping continuity under his RT. Chronology is now intact. Apology for move. Image
Here is a link to PART 1 of “The Disregard of Informed Consent & Echoes of Nuremberg” (is hash tagged as #InformedConsent). That thread's continuity is intact and extensive, from March 31 to Aug 3.
Read 178 tweets
@GVDBossche "Initially ... new virus variants will mainly affect the [unvaccinated] ... [but] variants will eventually arise against which vaccines will no longer offer any protection. And from that moment on, vaccinated people will also be able to get sick."

overnu.nl/anatomie-van-e… Image
@GVDBossche "Central to Vanden Bossche's theories is the growing group of vaccinated people who can still become infected with the virus unnoticed and also transmit it. These people act like walking virology labs" Image
@GVDBossche "Herd immunity occurs when most of a population is immune to an infectious disease and thereby provides indirect protection to those who are not immune to the disease."
Read 30 tweets
#vaccins #ARNm & #dissensus : une longue vulgarisation de qualité ici sur leur mécanique, le risque de retranscription ADN et les précautions associées...
Jean-Yves Bilien interviewe le Dr Nawrocki qui débunke les mythes des jeunes médecins surs d'eux 😳 odysee.com/@Glorian:b/Dr-…
#sûreté #vaccinale : Accrochez-vous 😳 en très gros, le Spike serait mortel à petit feu, car induisant des anticorps contre la cardiolipine, sorte de gardien cellulaire dont l'absence déclenche la mort cellulaire... 😱 sources en bas du thread ⏬ Qui veut un 💉 au spike?
#sureté #vaccinale : Nouvelle alerte sur le risque de maladies dégénératives induites par la #présence de Spike dans le cerveau 😱
Read 33 tweets
#ADE (Antibody Dependent Enhancement) oder #Infektionsverstärkende Antikörper.

Ein Problem bei den #COVID19 #Impfstoffen?

Was ist das? Wurde es überprüft bei der Entwicklung der Impfstoffe? Und gibt es Hinweise, dass ADE ein Problem sein könnte?

Ein (langer) Thread
1/n
Eingangs: Sie sollen selbst entscheiden, ob Sie sich impfen lassen oder nicht. Sie sollen diese Entscheidung aber auf Basis wissenschaftlich fundierter Informationen treffen können.

Also, was ist ADE?
Nach Infektion / Impfung stellt der Körper spezifische Antikörper (Ak)...
2/n
gegen den fremden Eindringling her. Also zbsp im Falle der Impfung gegen das Spike Protein. Solche 'guten' Ak nennt man 'neutralisierende' Ak.
Soweit tiptop. Die Schützen vor Infektion/Krankheit.

ADE ist, wenn der Schuß nach hinten losgeht. Dann verschlimmern diese Ak...
3/n
Read 17 tweets
In the week of Jun 14-21, 2021 in England, #DeltaVariant cases of unvaccinated, 1 shot, 2 shots increased 18301, 6402 and 3148. The deaths increased 10, 9 and 24. Unvaccinated, 1 shot and 2 shots population ratios are about 25%, 25% and 50%. ImageImage
If normalized to the same population, the deaths increased 10, 9 and 12❗️
Compared to unvaccinated,
2 shots reduce #DeltaVariante cases to a factor of 3148/(183012*2)=0.086❗️
While death rate after infection increases by a factor of (24/3148)/(10/18301)~=14 ⁉️😱
What does it mean?
Compared to unvaccinated,
2 shots do reduce the chance of catching #DeltaVariant to a factor of 0.086 or about 1/12❗️
But if catching it, its death rate increases 14 times ⁉️😱
So the overall death rate increase to 1.2 times ⁉️Appears to me #vaccines do harm😱
Read 55 tweets
What is #ADE !

major goal of antibodies is to bind to the pathogen and prevent it from infecting, or entering, a cell. Antibodies that prevent entry into cells are called neutralizing antibodies. Many vaccines work by inducing neutralizing antibodies.
However not all antibody responses are created equal. Sometimes antibodies do not prevent cell entry & on rare occasions, they may actually increase the ability of a virus to enter cells & cause a worsening of disease through a mechanism called antibody-dependent enhancement ADE.
ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response.
Read 25 tweets
#Spike protein’ is the major target of #NAbs in infected/vaccinated people. The prefusion conformation of the Spike represents the most relevant target because Abs can successfully interfere w/ infection only if they prevent binding to target cells or prevent fusion itself 1/
Various approaches are adopted to express ‘#Spike’ protein in vivo, such as nucleic acid structures & virus vectors. Alternatively, other vaccine platforms like recombinant protein particles & inactivated vaccines can directly deliver this protein 2/
Most structural studies of the wild-type spike protein exhibited one #RBD in the 'open' conformation. By contrast, 2 or 3 RBDs were observed in the open conformation in the more infective #D614G mutant--the RBD #conformation plays a vital role in the infectivity of SARSCoV2 3/
Read 16 tweets

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