Discover and read the best of Twitter Threads about #AGEP
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#AGEP (ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS)!
A #medtwitter #dermtwitter #tweetorial! #MedEd #FOAMEd
This is a drug reaction that we can see on inpatients, with an exam full of pustules!
Let's start with a question - How long after drug exposure does AGEP appear?
#AGEP (ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS)!
A #medtwitter #dermtwitter #tweetorial! #MedEd #FOAMEd
This is a drug reaction that we can see on inpatients, with an exam full of pustules!
Let's start with a question - How long after drug exposure does AGEP appear?
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The correct answer is 24-48 hours!
The other answers are typical time frames for other types of reactions.
Urticaria usually manifests minutes to hours after drug exposure.
Morbilliform drug eruptions occur 4-14 days after drug exposure.
DRESS occurs 2-6 weeks afterward!
The correct answer is 24-48 hours!
The other answers are typical time frames for other types of reactions.
Urticaria usually manifests minutes to hours after drug exposure.
Morbilliform drug eruptions occur 4-14 days after drug exposure.
DRESS occurs 2-6 weeks afterward!
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Unlike DRESS and morbilliform eruptions, AGEP doesn't require repeated exposure of drug. So one single dose can definitely cause AGEP. A typical place we see this is with perioperative antibiotics!
Common culprits are Penicillins, quinolones, sulfa, antifungals, and CCBs!
Unlike DRESS and morbilliform eruptions, AGEP doesn't require repeated exposure of drug. So one single dose can definitely cause AGEP. A typical place we see this is with perioperative antibiotics!
Common culprits are Penicillins, quinolones, sulfa, antifungals, and CCBs!
Thanks, @MelBreggs for the mention, and thank you to @gopiastik for a great #tweetorial on #AGEP (acute generalized exanthematous pustulosis). I would add a couple thoughts here. Please read on!
#MedEd #FOAMEd #derm #dermatology #dermatologia #medthread PC: @dermnetnz
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#MedEd #FOAMEd #derm #dermatology #dermatologia #medthread PC: @dermnetnz
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First of all, the name AGEP can be confusing, but really all it is a description (we dermatologists just like to sound #fancy). If you break it down, Acute (really quick onset) generalized (everywhere), exanthematous (rash-y), pustulosis (pustules)!
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The exam is red plaques studded with pustules (see photo). These pustules can coalesce and become "lakes of pus!" The 2nd picture doesn't have pustules b/c all of them came together, lifted off, and left the "collarette" of scale (which means there's a footprint leftover!
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