Discover and read the best of Twitter Threads about #APOE4
Most recents (3)
1/5) IT WORKED! How I lowered by blood Mercury level by adding a Special Mayo 👇 - Thread 🧵
For background, I eat fish 1-2 times per day.
As such, my blood mercury has been running higher than ideal, usually around 13 mg/dL
#fish #mercury #mediketo #mayo
For background, I eat fish 1-2 times per day.
As such, my blood mercury has been running higher than ideal, usually around 13 mg/dL
#fish #mercury #mediketo #mayo
2/5) My reasons for eating fish frequently are bc I enjoy the taste and as an #ApoE4 homozygote (#Alzheimers risk gene) my understanding of the research is that the more real-food EPA/DHA I can get the better!
Paper: mdpi.com/2072-6643/13/4…
Lecture:
Paper: mdpi.com/2072-6643/13/4…
Lecture:
3/5) Front line advice for keep Mercury levels in normal range is to eat fish low on the food chain & to avoid big fish like tuna and swordfish.
For ref, a table of Mercury levels in fish. You can see, swordfish has ~77-times as much mercury as sardines
fda.gov/food/metals-an…
For ref, a table of Mercury levels in fish. You can see, swordfish has ~77-times as much mercury as sardines
fda.gov/food/metals-an…
1/ Wow!
Interesting study about HDL-raising & LDL-lowering medications, CETP & PCSK9 inhibitors, w 1 finding that caught me off guard
Will reveal later in thread 2encourage ppl 2read in context, bc study revealed both good and bad
#CVD #Alzheimers
nature.com/articles/s4146…
Interesting study about HDL-raising & LDL-lowering medications, CETP & PCSK9 inhibitors, w 1 finding that caught me off guard
Will reveal later in thread 2encourage ppl 2read in context, bc study revealed both good and bad
#CVD #Alzheimers
nature.com/articles/s4146…
2/ Study used Mendelian randomization 2assess possible effects of SPECIFIC pharmacological CETP or PCSK9 lowering on risk
Useful for assessing whether the failures of CETP inhibitors are more likely due to off-target or on-target effects and for directing future development...
Useful for assessing whether the failures of CETP inhibitors are more likely due to off-target or on-target effects and for directing future development...
3/ Some positive things:
👉MR analysis suggests CEPT inhibition could be useful4reducing coronary hard disease risk (OR=0.95) risk & thus further drug development may be warranted
👉CEPTi anacetrapib&evacetrapib most closely
reflected the on-target association of lower CETP...
👉MR analysis suggests CEPT inhibition could be useful4reducing coronary hard disease risk (OR=0.95) risk & thus further drug development may be warranted
👉CEPTi anacetrapib&evacetrapib most closely
reflected the on-target association of lower CETP...
🚨🧠📄🍾 🤪🥳 For some reason all our papers are coming our within 2 weeks!
Here’s the latest in @GreenJournal, on the relationships between 1) patterns #tau and #amyloid PET and 2) #Alzheimer’s clinical #heterogeneity and #APOE4.
n.neurology.org/content/early/…
1/n
Here’s the latest in @GreenJournal, on the relationships between 1) patterns #tau and #amyloid PET and 2) #Alzheimer’s clinical #heterogeneity and #APOE4.
n.neurology.org/content/early/…
1/n
#Alzheimer is associated with #heterogeneous clinical presentations. Patients develop symptoms at different ages (even sporadic AD can start early) and clinical syndromes vary: not everyone shows a “typical” amnestic syndrome (which is not very sensitive nor specific to AD!)
2/n
2/n
Specific non-amnestic syndromes are often associated with AD, like #PosteriorCorticalAtrophy (PCA, the visual variant of AD) or the logopenic variant of Primary Progressive Aphasia (lvPPA).
#APOE4 is associated with an earlier onset but also a more amnestic syndrome.
3/n
#APOE4 is associated with an earlier onset but also a more amnestic syndrome.
3/n
