Discover and read the best of Twitter Threads about #ASAPseq
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Excited to share our latest single cell multimodal assay. ASAP-seq pairs surface and intracellular protein detection with high quality chromatin accessibility on the @10xGenomics #scATACseq platform.
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
By employing a bridge oligo approach, #ASAPseq allows protein detection with existing @bioLegend TotalSeq family conjugates and is compatible with hashing. If you are doing #CITEseq now, buying a bridge oligo (~$40) is all it takes to start doing ASAP-seq.
ASAP-seq takes advantage of the recent mtscATAC-seq work that demonstrated that whole fixed cells can give high quality scATAC-seq libraries, with mtDNA clonal architecture as an optional added bonus.
nature.com/articles/s4158…
nature.com/articles/s4158…
