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So here is a thread on the use of MRD in MM. Before we start please know that I consult for Adaptive & are part of their Scientific Advisory Board. If you can get past this point thank you for coming. Prompted by @End_myeloma
#MMSM #ASCO19RF @mtmdphd @AdaptiveBiotech
#MMSM #ASCO19RF @mtmdphd @AdaptiveBiotech
MRD negativity is now shown to be highly prognostic in several studies. Furthermore, the HR effect is unprecedented, and far more powerful than any genetic marker. Particularly see French (IFM) study from 2018.
bloodjournal.org/content/early/…
bloodjournal.org/content/early/…
Second point, IMHO, people are “dancing around” at the level of sensitivity, but to mee it appears that 10-6 should be the way to go. Some appease those who work with 10-5 but, truth be told, deeper is better.
