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#HematologyTweetstory 9: the “Philadelphia” chromosome! Whole books have been written about this saga; we’ll focus on some of the most interesting highlights. A shout-out to @LuskinMarlise – former @PennMedicine fellow & now @DanaFarber colleague - for suggesting this topic. /1 
The key discovery in a "nutshell" (karyo=nut in Greek): in 1959, David Hungerford (1927-1993) and Peter Carey Nowell (1928-2016) @Penn found a peculiar-looking tiny chromosome in cells from 7 patients w/ a disease then called “chronic granulocytic leukemia", now known as #CML./2
Nowell, a Philadelphia native, had graduated from @Penn in 1952 and then returned to join the faculty in 1956 after doing radiobiology research while in the US Navy. He started working on leukemia, not really sure where his research was going, then had a happy accident./3
