Discover and read the best of Twitter Threads about #ASHtrainees
Most recents (3)
#ASH22 Bone marrow failure syndromes: diagnostic principles in 2022. Starting with Sara Lewis, a genetic counselor in hematology. Follow this tweet for more. 1/n
Sara reminds us that she feels patients think more about their family history as they see her draw the pedigree. Time for me to start doing this! #phodocs #ASH22 #pearl 2/n
Here are the options for diagnostic workup - genetic tests can be done from somatic genes or germline! #ASH22 3/n 
And then he took from chapter 1 and applied it to chapter 2 - found that he could assess for mixed chimerism using restriction length polymorphism. And then.. time to find a job! And he wanted to bring it in to the clinic, so... #ASH22 6/n
Always love showing photos of the researchers earlier in their careers! So then he was able to establish a mouse a model of graft rejection. And tried in vivo cytokine injection to increase graft - tried lots of them, some toxic, some didn't work. 7/n #ASH22
Then tried donor NK cell depletion and CD4 and CD8 depletion -- but then tried L-leucyl-L-leucine methyl ester that worked but.. it couldn't be made in GMP - what a let down for a researcher, but real life. Thanks for sharing this roller coaster. #ASH22 8/n
Dr. Bruce Blazar presenting the E. Donnall Thomas lecture this year at #ASH22. @JaneWinterMD shares that his lab continues to bring new technology to preventing GvHD. 1/n
Humbly introducing Dr. Thomas and his contributions. (from his 1957 NEJM paper showing you could have natural acquired immunologic tolerance and radioprotection could induce graft tolerance!) Already feel like this #story is going to be so amazing. #ASH22 2/n
Cadaveric transplants! And then in the next 10 years 203 patients got BMTs and died but he pressed on! Then in 1961 they did a identical twin transplant for aplastic anemia! and then Dr. Thomas got the Nobel prize in 1990! 3/n #ASH22
