Discover and read the best of Twitter Threads about #ATESS

Most recents (1)

2 more NEGATIVE studies of #VitaminC in #sepsis: #ACTS in @JAMA_current & #ATESS in @yourICM.

It' doesn’t look good for the "metabolic cure”
5/6 negative for 1° endpoints; ORANGES found ⬇️ pressor use
5/6 with no mortality Δ; CITRIS did, but mortality was 1 of 46 2° endpoints
1/ Image
This is a great time to do some meta-analysis.

As you can see from my quick/simple analysis, neither vitamin C either alone or in combination with hydrocortisone and steroids reduced in mortality in people with sepsis:
2/ Image
What about other endpoints? It doesn't look much better for vitamin C: 4/6 found no ΔSOFA scores.

Also, while ΔSOFA scores and duration of vasopressors are important, I would argue that mortality is a more meaningful (and more patient centered) endpoint.
3/ Image
Read 6 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!