Discover and read the best of Twitter Threads about #Activ6

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The #Activ6 trial ivermectin 600μg/kg is a scientific fraud. medrxiv.org/content/10.110…
Here is how they justify dosage and duration: "a possible anti-viral activity with increasing dose." citing Krolewiecki et al. study.
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If we look at the protocol of the activ6 trial published as a supplement of the 400μg/kg arm published in the JAMA: jamanetwork.com/journals/jama/…, here is the rationale for selection of dose (600μg/kg).
2/n
Reference 66 is Krolewiecki et al. study. 1rst problem: Krolewiecki study doesn't contain a 300μg/kg as they claim here. What is right is "The anti-viral activity was identified in the subgroup of patients on ivermectin with higher mean plasma concentrations."
3/n
Read 15 tweets


Tout le monde saute sur le dernier préprint de Boulware et cie, le mec qui ne serait pas capable de détecter à l'aveugle une différence entre une pomme et une orange.
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Rappelons donc que cette étude hérite des biais similaires au bras IVM 400μg/kg d'#activ6, même si on aurait pu espérer que la meilleure posologie (dosage et durée) apporte des résultats positifs:
1/ Traitement à jeun.
2/n
2/ Données manquantes dans les sous-groupes
3/ Hétérogénéité dans le délai du traitement rendant l'analyse statistique caduque

4/ Un sous-groupe de patients déjà guéri à J1 (No symptom)
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Read 10 tweets

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