Discover and read the best of Twitter Threads about #Adenovirus

Most recents (23)

#HÉPATITE INFANTILE ATYPIQUE - THREAD 2

Ça faisait longtemps...

Alors que je le concentrais sur la variole, le consensus sur un lien entre les infections #covid19 et ces mystérieuses hépatites touchant les #enfants s'est solidifié.

Et, les cas s'accumulent.

Faisons un point.
RAPPORT OMS DU 26 MAI

650 cas (+181)
38 transplantations (+12)
9 morts (+3)

Dans 33 pays (+11)

Le rapport : who.int/emergencies/di…

#Hepatite #Covid19 #Adenovirus #Enfants

Le tableau :
Read 11 tweets
#OutBreak of acute #hepatitis among #children
650 probable cases of acute hepatitis of unknown
aetiology in children have been reported to WHO from 33 countries in 5 WHO Regions between 5 April and 26 May 2022.
1/
who.int/emergencies/di… Image
- Three quarters (75.4%) of cases are 5 years of age.

- Of 156 cases with information on hospital admission, 22 (14.1%) were admitted to an intensive care unit.

Of the 117 cases for which this information was available, 14 (12%) have received a liver #transplant.
2/
- Overall, 181 cases were tested for #adenovirus by any specimen type, of which 110 (60.8%) tested positive. The positivity rate was the highest in whole blood specimens (69.5%).
3/

Table. Classification of reported probable cases per country Image
Read 7 tweets
Warum wir weiterhin in kluge Virus-Überwachung investieren sollten, warum wir uns nicht nur auf Daten aus anderen Ländern verlassen können & welche Viren neben #SARSCoV2 noch wichtig sind #COVID19 #Adenovirus #Schweiz @Hopitaux_unige @unige_en - nzz.ch/wissenschaft/w… via @NZZ
Wichtig ist, dies sind nicht reine Forschungs-Fragestellungen, sondern essentielle Aspekte für Diagnostik, Therapie & Impfung. Leider klafft hier eine Lücke: Von der Forschungsförderung wird es oft als nicht fundamental genug angesehen, von Public Health Seite aber als Forschung
Eine wichtige Diskussion, die wir in der Zukunft führen müssen, es braucht dafür schweizweite Strukturen & Finanzierung, aber vor allem auch den Aufbau von nachhaltigen, belastbaren Kompetenzen, mit hochspezialisierten funktionellen Testen & qualifiziertem Personal zur Bewertung
Read 4 tweets
HEPATITIS AGUDA INFANTIL de origen desconocido

¿Realmente la está causando el #Adenovirus F41? 🧐

Hay algunos puntos a considerar. Va mi opinión al respecto🧵👇🏼

1/15

#HepatitisAgudaInfantil
Hace un mes (15Abr22) nos enteramos de que Reino Unido 🇬🇧 estaba reportando un incremento inusual en los casos de #hepatitis de origen desconocido en pacientes pediátricos, especialmente en l@s más jóvenes

Después otros países empezaron a reportar lo mismo (tot: 169 casos)

2/15
La presentación clínica, es decir, la manera en la que el personal médico identifica la enfermedad👩🏻‍⚕️, es una #HepatitisAguda (el surgimiento rápido de inflamación en el hígado) con una elevación muy pronunciada 📈 en los niveles de proteínas provenientes de ese órgano¹

3/15
Read 16 tweets
1/
Hace ya 5 semanas que @ECDC_EU activó la alerta por los casos de #hepatitis agudas graves en niños de causa desconocida

¿Qué hay de nuevo?

📈 Más de 400 casos en estudio
📉 Caída de casos en 🇬🇧
🤔 Información sobre la posible causa
⁉️ Muchas preguntas

#livertwitter #COVID19
2/
Antes de seguir puedes revisar donde estábamos hace unas semanas

👇👇👇

3/
El número de casos compatibles ha aumentado, en parte porque se han ampliado los criterios de búsqueda, era esperable:

🇬🇧 163
🇪🇺 106
🇺🇸 109

Llama la atención el "bajo" número de casos sospechosos (para la población) de la UE y USA 🤔

#livertwitter
Read 20 tweets
1. Interesting update on #PediatricHepatitis from @ECDC_EU + @WHO_Europe. It contains the first epicurve I've seen, which is very helpful because reported cases include current & previous cases found through record searches. The 1st case here dates to Sept 2021.
2. A large majority of the European #PediatricHepatitis cases are really young — 76% under the age of 5.
3. The @ECDC_EU/@WHO_Europe #PediatricHepatitis update says as of May 13, a total of 232 cases have been reported. Puzzled by the UK number (131) because yesterday @UKHSA reported 176 cases.
This report reports 3 epidemiologically linked cases, which is interesting.
Read 7 tweets
1. @WHO held a press briefing today. Some interesting but disparate points made at it.
Pediatric #hepatitis: To date 348 probable cases from 5 regions of the world have met the case definition; 70 more are being studied. Only 6 countries have reported more than five cases.
2. Of the pediatric #hepatitis cases, 70% have tested positive for adenovirus, mostly type 41. ~18% of the cases tested positive for #Covid19. @WHO's Philippa Easterbrook says while adenovirus is still the chief suspect, prior or current Covid as a cofactor is still in the mix.
3. @WHO's Easterbrook says "within the week" there should be data from a UK case control study comparing adenovirus rates between kids with hepatitis of unknown etiology and other hospitalized children. Will help to see if #adenovirus is an incidental finding, she said.
Read 8 tweets
Unknown #Hepatitis in #children: From my point of view as a clinical virologist, there are many aspects that speak against #Adenovirus, with important implications for treatment. Why? Viral loads in the cases reported to be low. Normally viruses causing hepatitis are massively
found in the blood. Hepatitis virus A, B, E, when causing fulminant clinical hepatitis: very high viral loads (C rarely causes this). Same for other viruses with hepatic tropism (eg Yellow fever). Viral hepatitis with pronounced clinical picture but low viral loads doesn’t exist
Now in the children with hepatitis no Adenovirus was detected in the liver biopsies, and viral load in blood was low. In some cases, Adenovirus DNA only in whole blood but not plasma. Again: a virus that is replicating in liver should be found everywhere: plasma, serum, biopsy
Read 10 tweets
Gut, dass auch in #Deutschland darüber berichtet wird - wichtige Aufklärung für Eltern. Allerdings: Dass ein bekanntes #Adenovirus plötzlich eine neue Pathogenese hat, ist genauso wahrscheinlich oder unwahrscheinlich wie eine unbekannte Komplikation nach #SARSCoV2 #COVID19 1/n
Für die Lockdown-Theorie gibt es keinerlei wissenschaftliche Evidenz, schon garnicht da gerade Adenoviren (unbehüllte Viren, viel umweltstabiler & resistenter gegen Desinfektionsmittel) auch während der Pandemie zirkulierten. Die gute Nachricht ist, dass wir in #Deutschland 2/
& #Schweiz bislang noch keine Häufung an Fällen beobachtet haben. Wie von Prof. Wedemeyer richtig gesagt: Wir sind im epidemiologischen Geschehen zeitlich hinter UK. Und: Detektion von Adenoviren kann Zufall sein, da diese Viren gerade stark zirkulieren (Kontrollgruppe fehlt) 3/
Read 5 tweets
🚨 New study, relevant to 'mystery' child #Hepatitis.
🚨69% autopsied livers SARS-COV-2 RNA +
🚨Proteomic- etc profiles show "similarities to signatures assoc with multiple other viral infections of human liver" BUT was shown to be covid inf of hep cells

nature.com/articles/s4225…
@sajidjavid @HumzaYousaf @NHSuk
Evidence of DIRECT SARS-COV-2 infection of hepatic cells ➡️ interferon spike ➡️ hepatitis. Paper clearly states it may look like another virus but investigation proves IT IS NOT. It's SARS-COV-2.
Can we call this duck a duck now?
Protect our kids
Read 7 tweets
C'est tout chaud et ça parle des #hepatite
Thread

gov.uk/government/pub…
111 cas d'#hépatite chez des moins de 16 ans, depuis janvier 2022, un début de maladie ressemblant à une gastro avec jaunisse. Pas de décès UK, beaucoup de moins de 5 ans, 40 cas d'adénovirus sur 53 cas testés.

D'où l'hypothèse première d'une origine virale ou immunologique.
Ces cas ont été rapportés par pays. #hepatite

Sur 81 cas en Angleterre, 7 ont du être transplantés. Aucune intoxication au paracétamol n'a été retrouvée. On notait une sur-représentation des positifs au #SARSCoV2 et l'adénovirus 40 fois sur 53, dont 11 de type 41F.
Read 10 tweets
Unklare #Hepatitis-Fälle bei #Kindern - eine Einordnung meinerseits. Seit einigen Wochen werden vermehrt Hepatitis-Fälle bei Kindern unter 10 Jahren (Gipfel 2-5) gemeldet, bislang aus UK, Dänemark, Niederlande, Spanien, Israel und nun auch USA, mit Beginn wohl schon in 2021
Aktuelle Daten findet man hier (ECDC) ecdc.europa.eu/en/news-events… und auch hier promedmail.org (PromedMail), bei letzterem allerdings auch ungeprüfte Quellen. Vorläufige Falldefinition & erste Publikation aus Schottland hier: eurosurveillance.org/content/10.280…
Vorab sei gesagt, dass es noch sehr früh ist & man wirklich noch nichts genaues weiß. Es ist im Moment wichtig, nicht zu schnelle/voreilige Schlüsse zu ziehen. Man kann auch alle nur darum bitten, Thema nicht für eigene Agenda zu missbrauchen & Fehlinformationen zu verbreiten.
Read 24 tweets
Mix It Up:

💉You can freely select between Pfizer & Moderna for your 3rd dose, regardless of which one you used for the 1st and 2nd doses

💉I expect J&J (adenovirus) will suggest a booster

💉I predict you will be allowed to switch (from adenovirus) to mRNA for the booster dose
Adenovirus + mRNA:

💉Data suggests adding mRNA booster to those who took an #adenovirus vaccine (eg J&J) results in increased protection compared to boosting with adenovirus for a second time

💉The AstraZeneca adenovirus vaccine was used in this study

👉thelancet.com/journals/lance…
mRNA:

💉Moderna had more side effects (9.7% fatigue) than Pfizer (3.8% fatigue) in 1st/2nd doses

💉I predict Moderna 3rd dose will be a half-dose of 1st/2nd doses (less side effects)

💉Moderna protection from 1st/2nd doses isn’t waning as fast as Pfizer
yalemedicine.org/news/covid-19-…
Read 3 tweets
In the week of Jun 14-21, 2021 in England, #DeltaVariant cases of unvaccinated, 1 shot, 2 shots increased 18301, 6402 and 3148. The deaths increased 10, 9 and 24. Unvaccinated, 1 shot and 2 shots population ratios are about 25%, 25% and 50%. ImageImage
If normalized to the same population, the deaths increased 10, 9 and 12❗️
Compared to unvaccinated,
2 shots reduce #DeltaVariante cases to a factor of 3148/(183012*2)=0.086❗️
While death rate after infection increases by a factor of (24/3148)/(10/18301)~=14 ⁉️😱
What does it mean?
Compared to unvaccinated,
2 shots do reduce the chance of catching #DeltaVariant to a factor of 0.086 or about 1/12❗️
But if catching it, its death rate increases 14 times ⁉️😱
So the overall death rate increase to 1.2 times ⁉️Appears to me #vaccines do harm😱
Read 55 tweets
Dr Robert Malone - Q: Why do you call the #adenovirus-based (J&J) and #mRNA-based #vaccines #gene therapy-based vaccines? And why is that important? Are you just trying to scare people? Are you an #antivaxxer? linkedin.com/feed/update/ur…
why gene therapy-vaccines? both types of vaccines employ technologies that involve transfering foreign genetic material into the cells of the person receiving the vaccine, making those cells essentially become miniature vaccine antigen manufacturing factories - inside the body👉
for vaccination, the "active drug substance" is not the gene therapy vector, it is the protein that is manufactured in your cells.from an FDA/regulatory point of view, these products need to be reviewed using the regulations applied to "gene therapy" products ... 👉
Read 7 tweets
La vacuna Sputnik V COVID-19 utiliza dos virus "inofensivos" (adenovirus) que "inyectan" una parte del código genético del coronavirus a nuestras células para producir unas determinadas proteínas virales:
Sputnik V es una vacuna de vector viral diseñada para producir inmunidad duradera contra #COVID19. Según un análisis intermedio de los datos de los ensayos clínicos de fase 3 publicados en @TheLancet , la eficacia de esta vacuna es 91,6%
thelancet.com/journals/lance…
¿Qué es un vector viral?
Un vector viral es un virus inofensivo que puede transportar un gen extraño a nuestras células para que estas produzcan una determinada proteína. Los científicos han estudiado el uso de vectores virales para terapia génica y vacunas.
Read 7 tweets
"#AstraZeneca, we have a problem"

New #preprint from Lena Krutzke and Stefan Kochanek et. al. @uni_ulm and @UniklinikUlm on @researchsquare

"Process-related impurities in the ChAdOx1 nCov-19 vaccine"

Why is this a problem? A short thread (1/8) 👇
researchsquare.com/article/rs-477…
"The intramuscular injection of proteins that are not part of the active principle of the #vaccine itself might have effects at different levels"

That`s why removal of impurities (e.g. host-cell proteins) is critical for #therapeutics and strictly regulated
(2/8)
Unfortunately, removal of process-related #impurities from viral vector-based #therapeutics (e.g. host-cell proteins) is imperfect and low levels - orders of magnitude lower than the actual active therapeutic - are usually accepted if they are classified as non-problematic
(3/8)
Read 9 tweets
Del 20 al 27 de abril se vacunarán a más de 90 mil trabajadores del sector educativo e México

La vacuna #COVID19 de #CanSinoBiologics, se aplicará a docentes tanto públicos como particulares.

Por eso hoy les daré algunos datos sobre esta vacuna.

Abro hilo 🧵
¿Qué tipo de #VacunaCOVID19 es #CanSino?

Es una vacuna vector, quiere decir que ocupa otro virus que se hace pasar por el #SARSCOV2, en este caso un #adenovirus, el cual al introducirse al organismo induce la producción de anticuerpos creyendo que es el #coronavirus.
Esta vacuna se construyó utilizando una plataforma conocida como #Admax.
 
¿Y como la hicieron? Les cuento, al adenovirus Ad5 le quitaron sus genes E1 y E3, con lo que al entrar a nuestro cuerpo se generan anticuerpos en el día 14, con un pico máximo de estos al día 28.
Read 17 tweets
#idboardreview 50 M s/p liver transplant cmv D+/R- 28d ago now w/ dyspnea, fever, sore throat, myalgias, cough, yellow sputum x2d➡️hypoxia, ALT3k AST1k TBili2.3. Liver Biopsy: intranuclear eosinophilic inclusions. Dx? #medEd #idmedEd #IDTwitter Image
Read 10 tweets
¿CUÁL ES LA MEJOR VACUNA CONTRA #COVID19? 💉🧬🦠

En México hasta el 21/02/21, se han autorizado 5 vacunas: #Pfizer, #AstraZenaca, #SputnikV, Cansino y Sinovac.

Hoy les hablo de cada una de ellas: mecanismo, eficacia, seguridad, etc, para que tomes la mejor decisión.

Abro hilo
De acuerdo a datos de la @WHO, el #SARSCoV2 ha infectado a + de 110 millones de personas en el mundo, provocando casi 2.5 millones de defunciones 😷🦠⚠️

México 🇲🇽 ocupa el tercer lugar en muertes a nivel mundial 🌎
De ahí que actualmente existan más de 100 distintos tipos de vacunas desarrollándose contra este virus.

Además de las ya mencionadas, existen otras fórmulas que se están utilizando alrededor del mundo tales como #Moderna, #Novovax ó #Johnson & Johnson.
Read 33 tweets
1/ @AstraZeneca & @OxfordVacGroup Faz3 #AZD1222 #aşı çalışması, 2 gönüllünün farklı zamanlarda aşılanma sonrası Transvers miyelit (TM) olması sebebiyle, iki kez durdurulup, tekrar başlatılmıştı. Şimdi Klinik Araştırma Protokolü (blueprint) basına sunuldu.

nytimes.com/2020/09/19/hea…
2/ Daha 3 gün önce @moderna_tx, normalde gizlenen ve aşı çalışması bitmeden sunulmayan blueprinti kamuoyuyla paylaşmıştı. Bilim insanları, 3 Kasım’daki Amerika Başkanlık Seçimleri’nin, ilaç firmaları ve CEO’ları üzerindeki baskısı olmasından çok endişeli.
nytimes.com/2020/09/17/hea…
3/ Faz3, en önemli ve en masraflı aşı çalışması basamağıdır, on binlerce gönüllünün katılımıyla uluslararası gerçekleştirilir. Aşı güvenliğinin ve etkinliğinin reel değerleri asıl bu kademede belirlenir. Herhangi bir komplikasyonda, detaylar kesinleşinceye kadar durdurulmalıdır.
Read 11 tweets
At least 7 teams are developing #SARSCoV2 #vaccines using a weakened / inactivated virus. Several existing vaccines are made this way, i.e. #measles & #polio #vaccine. Sinovac Biotech started to test an inactivated SARS-CoV-2 #COVID19 vaccine. #scicomm
At least 25 groups are working on viral-vector #SARSCoV2 #COVID19 #vaccines. A #virus such as #measles or #adenovirus is genetically engineered so it can produce #coronavirus #proteins in the body. These #viruses are weakened so they CANNOT cause disease.
At least 20 teams are using genetic instructions (#DNA or #RNA) for a #SARSCoV2 #coronavirus #protein that prompts an immune response. The nucleic acid is inserted into human cells, which churn out copies of the #virus protein; most encode the virus’s spike protein. #COVID19
Read 5 tweets
An #outbreak of 27 cases of unidentified viral #pneumonia in #China, including potential exposures at a local market, has drawn comparisons to the emergence of #SARS. But does the evidence support those concerns? #OutbreakThursday
outbreakobservatory.org/outbreakthursd…
#Wuhan Update- Jan 3: 44 cases of viral #pneumonia, incl 11 "critically ill." Monitoring 121 contacts. Still no evidence of person-to-person transmission or HCW infections & no identified cause. Conducting genetic and culture tests. #SARS #Flu #China
wjw.wuhan.gov.cn/front/web/show…
#Singapore has identified a #pneumonia patient with recent travel to #Wuhan. Preliminary tests are positive for #RespiratorySyncytialVirus (#RSV) & the patient is in isolation as a precaution. #China #SARS #Outbreak
bloomberg.com/news/articles/…
Read 52 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!