Discover and read the best of Twitter Threads about #Alanine
Most recents (2)
Let’s shift our focus from Spike to #Nucleocapsid protein!
A new study demonstrates that genetic mutations outside the Spike are also key components in #SARS2 continued adaptation to human infection.
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A new study demonstrates that genetic mutations outside the Spike are also key components in #SARS2 continued adaptation to human infection.
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The #R203K-#G204R mutation is sufficient to enhance replication, fitness, & pathogenesis of #SARS2. Importantly, the R203K-G204R mutation increases #nucleocapsid phosphorylation, providing a molecular basis for these phenotypes.
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Notably, an analogous #alanine substitution mutant also increases #SARS2 fitness and phosphorylation, suggesting that infection is enhanced through ablation of the ancestral ‘RG’ motif. A new Preprint by @TheMenacheryLab 👇
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biorxiv.org/content/10.110…
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biorxiv.org/content/10.110…
My recent DNA #nucleobase etymology thread turned out to be surprisingly popular. So now let's do the amino acids -- #HematologyTweetstory 12. This pretty chart of the #aminoacids is from “BioNinja”: ib.bioninja.com.au/standard-level…
Knowing word origins isn't essential to using terms well, but these histories can be interesting and illuminating. So, while you may not be a bodybuilder💪🏋️♂️🏋️♀️ who eats amino acids to bulk up, you can read #HematologyTweetstory 12 to build up your “body of knowledge". 😉
Let’s start with #Arginine, “the pirate’s favorite AA” (Arrrr!)🤪, first isolated by Ernst Schulze in Zürich (1886) from lupin seeds. His arginine crystals looked silvery; the Greek word árgyros (ἄργυρος)=silver. Argentina, rich in silver ore, gets its name from the same root./2
