Discover and read the best of Twitter Threads about #AllCauseMortality

Most recents (4)

1/ This new MR study by @mendel_random, @mvholmes, et al makes use of UK Biobank data and determines #ApoB increases risk of #AllCauseMortality, and even #T2Diabetes

This is actually relevant timing as we are rapidly approaching the #LMHRstudy. sciencedirect.com/science/articl…
2/ If you didn't already know, "Lean Mass Hyper-responders" (#LMHRs) would be considered hypercholesterolemic, with this resulting from being very low carb (typically #keto), and are often lean and/or athletic.

(You can read more on this phenotype at CholesterolCode.com/lmhr)
3/ Setting aside why this population exhibits this (see #LipidEnergyModel for more), the most important question is whether they are at risk.

This MR study builds on the existing conventional expectation that they are, and no less in a dose-dependent manner...
Read 6 tweets
A large soon to be published meta-analysis by Dr Bill Harris (@FariOmega3) et al of 17 prospective studies shows #AllCauseMortality risk was significantly lower among individuals with the highest circulating levels of EPA/DHA #Omega3. #AntiAging #Longevity repository.cam.ac.uk/handle/1810/31… Image
Now out in @NatureComms: "Here, we show significant inverse associations for all mortality endpoints with #Omega3 levels. Hence, chronically higher tissue levels of these FAs operating through a variety of potential mechanisms may slow the aging process." nature.com/articles/s4146…
"In summary, in a global pooled analysis of prospective studies, long chain #Omega3 PUFA levels were inversely associated with risk for death from all causes and from CVD, cancer, and other causes." #AntiAging ImageImage
Read 3 tweets
1/ As you know, I'm keenly interested in #AllCauseMortality in particular...

"Over the 31 days ending April 4, more than twice the typical number of New Yorkers died."

nytimes.com/interactive/20…
2/ "These numbers contradict the notion that many people who are dying from the new virus would have died shortly anyway."

At a certain effect size, this statement is certainly more likely.
3/ "... But even if the current count is perfect, roughly 9,780 people have died of all causes over the past month in New York City, about 5,000 more than is typical."
Read 4 tweets
1/ #ListenThread -

My guest appearance on #SigmaNutritionRadio just dropped where I have a very friendly #debate with @NutritionDanny and Alan Flanagan on #LDL #Cholesterol, #ApoB, #Atherosclerosis, #AllCauseMortality & much, much more!

sigmanutrition.com/episode321/
2/ I did this podcast semi-sleep deprived and between interviews for #TheCCDoc. But I know my main hopes going in were to emphasize:

(1) Why I favor the "Lipid profile-centric" model over the "Lipoprotein-centric" model.
(2) How this is relevant to "the triad" ⬆️LDL⬆️HDL⬇️TG
3/

(3) Why this triad is of particular interest to all of us as it relates to not just cardiovascular disease, but in particular -- all cause mortality (ACM)

I honestly couldn't remember how well I did in getting these core points across, thus relistening now...
Read 64 tweets

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