Discover and read the best of Twitter Threads about #Alzheimer

Most recents (24)

Alzheimer… Karena TIDAK semua PIKUN pada Lansia itu HAL YANG BIASA..

~Thread~

Pernah ga denger cerita ada orang tua nyasar.. ga inget rumahnya di mana..

Terus dikira orang gila (ODGJ).. Bisa jadi beliau mengalami alzheimer loh..
#Alzheimer #AlzheimersDay
1 dari 9 orang usia 65 thn ke atas bisa mengalami #Alzheimer ..

Otak manusia bisa menyusut seiring dgn usia.. Tp pada orang Alzheimer “menyusut” nya itu “keterlaluan…

Akibatnya timbul gejala kepikunan yang “hebat” dan cepet banget ilang ingatannya
Jaringan otak yang “menyusut” ini diakibatkan oleh terbentuknya protein “tau” yang mengacaukan struktur normal sel otak

Sampai sekarang penelitian masih berlanjut untuk mencari tahu kenapa ada orang yang mengalami hal seperti ini
Read 4 tweets
Arlan Richardson showing that JAX-housed mice, like humans, have undergone a dramatic improvement in #lifespan this century ... by reducing deaths from pathogens. #MindYourModels
Recommends looking at lifespan data as the best indicator of husbandry quality at different institutions/sources. Mean survival should be at least 27-30 months.
Example: 2003 Igf1r study showing 33% lifespan extension (in het ♀️s), but mean lifespan of controls was only 19mos. Lifespan effect largely disappeared when replicated in cohorts with longer control lifespan.
This was my go-to question for fly lifespan studies as a postdoc.
Read 7 tweets
Llega el momento de hablar del supuesto efecto imán de las vacunas que tan famoso se está haciendo cada día que pasa. Tratando de ser lo mas imparcial posible y después de varias semanas de leer artículos médicos de todo tipo, voy a exponer la conclusión a la que llego con este
fenómeno extraño y desconocido hasta ahora.
Edward Hutchinson , profesor del Centro de Investigación de Virus de @UofGlasgow , en declaraciones a @Newsweek afirmó que las vacunas contra el #coronavirus no contienen ningún ingrediente que sea capaz de producir este efecto.
"En segundo lugar, incluso si lo fuera, necesitaría introducir un gran trozo de material magnético debajo de la piel para obtener la acción que los videos demuestran. Si desea intentarlo, intente conseguir un imán de nevera para recoger cualquier cosa, en particular pequeños
Read 22 tweets
ALERTA DE NOVO MEDICAMENTO APROVADO PARA O ALZHEIMER. 🚨 O #aducanumab acaba de ser aprovado pelo @US_FDA para o tratamento da doença de #Alzheimer. Eu, o @wagnersbrum e o @jpfsouza33 resolvemos fazer um resumo dessa história cheia de controvérsias. Segue o 🧶 1/n
A demência é um dos maiores desafios do século XXI na área da saúde, acometendo 50 milhões de pessoas ao redor do 🗺️ (a projeção é de 152 milhões em 2050). O #Alzheimer é a principal causa de demência, sendo responsável por 60-70% dos casos. 2/n
Muito debate-se sobre a causa do #Alzheimer. Mesmo que não seja consenso, a teoria dominante é a da cascata da proteína beta-amiloide (descrita nos anos 90), a qual propõe que o acúmulo dessa proteína no 🧠 funcionaria como um gatilho para a morte progressiva dos neurônios. 3/n
Read 21 tweets
#Donanemab for #Alzheimer, misleadingly spun as positive: “donanemab resulted in a better […] ability to perform activities of daily living than placebo at 76 weeks”. The data suggest otherwise. (1/8)

#EliLilly @NEJM #ADPD2021

nejm.org/doi/full/10.10…
(2/8) First off, donanemab accomplished exactly what it was designed for: At 76 weeks, the reduction in the amyloid plaque level as assessed by florbetapir PET was 85.06 centiloids greater in the donanemab group than in the placebo group (−84.13 vs. 0.93 centiloids)
(3/8) However, the primary outcome, the composite iADRS (range, 0 - 144), showed a difference of only 3.20 points in favor of donanemab. While with a p=0.04, the trial was powered to show a 6-point difference. This goal was not reached, as the authors admit in the discussion.
Read 8 tweets
Lo que el #Año2020 nos dejo
1. Las 2 primeras vacunas ARNm de la historia, producidas en 🕛 récord, para prevenir formas sintomáticas de la infección por el #SARSCoV2.
a) @pfizer/ Biontech: BNT162b2 / 95% de efectividad
b) @moderna_tx: mRNA-1273 / 94.1% de efectividad
2. El #RECOVERY trial de la @UniofOxford y el #Solidarity trial de la @WHO q' demostraron el beneficio de usar dexametasona en pacientes hospitalizados con #COVID19 severo, y el NO beneficio de utilizar #hidroxicloroquina, cloroquina, interferon, lopinavir/ritonavir o azitromicin
3. Los 47 países del continente africano libres de #poliomelitis por el virus salvaje, según la @WHO 25/08/2020.
4. El fin de la epidemia de #Ébola en la república democrática del Congo, gracias a la única #vacuna vs el virus, llamada ERBEVO de @Merck.
Read 21 tweets
I deeply relate to this. After almost dying of ❤️ failure from #Lyme & being told by 11 “top” docs that in spite of my tick bite, bullseye, & classic symptoms, I could not poss still have it after a short course of doxy. Well, I did. 1/
And after the 12th doc saved my life (thx @StevePhillipsMD), I wrote my story in @HuffPost. I didn’t think anyone would care. But they did. The editor called & asked me to keep writing about this scandal as so many ppl were reading my story. 2/ huffpost.com/entry/how-11-t…
So I kept writing and began hearing from people all over the world, including a nurse from Ghana, who used my story to guide them back to health. I even interviewed celebrities who had gone through it like Daryl Hall. 3/ m.huffpost.com/us/entry/us_11…
Read 16 tweets
Important paper 👉 A team in Tokyo took RNA-seq data from the Genomic-#Tissue Expression Project: a public resource created to study tissue-specific gene expression/regulation from 54 tissue types collected from 1000+ healthy individuals at autopsy: bmcbiol.biomedcentral.com/articles/10.11…
2/ They successfully identified 39 viral species in at least one tissue (tissue types included #brain, pituitary, esophagus, thyroid, #heart, breast, lung, kidney, adrenal gland, prostate, #nerve, adipose tissue, blood vessel, ovary, uterus etc)
3/ Viruses identified in the various tissue samples included EBV, HSV-1, Varicella, CMV, HHV6-A/B, HHV-7, HCV, HPV, adeno-associated virus...and 16 RNA #viruses including Respiratory syncytial virus (RSV), Parainfluenza Virus 3..
Read 12 tweets
This is an incredibly important preprint to inform #LongCovid. Among many analyses, the team recruited 4 patients w/ prolonged + recurrent olfactory function loss after #COVID-19 (time from first COVID-19 symptoms to inclusion ranged from 110-196 days): biorxiv.org/content/10.110… Image
2/ None of these patients had detectable COVID-19 #RNA in nasopharyngeal samples by routine diagnosis (RT-qPCR). However, ALL patients had detectable COVID-19 RNA in samples obtained from their olfactory mucosa (confirmed with aRT-qPCR SYBR technique)
3/ Three of the patients had a high COVID-19 #viral load in the olfactory mucosa. Immunostaining additionally revealed the presence of COVID-19 antigens in 3 out of 4 patients. Based on that and related findings the team concluded...
Read 8 tweets
@jenbrea Hey! So I'm getting to the point where I could write a long paper about potential overlapping connections b/t #Alzheimer's and #MECFS, but I'll summarize a few top trends in this thread! First, I brainstormed often on topic with the late Rob Moir
@jenbrea 2/ Rob’s research (done w/ Rudy Tanzi + Will Eimer at Harvard) forms the core of a potential ongoing paradigm shift in Alzheimer’s - namely that #amyloid beta may be an antimicrobial peptide that forms in response to pathogens in #brain tissue: pubmed.ncbi.nlm.nih.gov/30001512/
@jenbrea 3/ To better understand that research, read this #interview I did with Rob before he passed away last year from glioblastoma. Key to ME/CFS is his work indicates that amyloid may form in response to herpesviruses like HSV1 in the Alzheimer’s brain: microbeminded.com/2017/12/18/int…
Read 14 tweets
We are thrilled to share our #preprint "Atlas of genetic effects in human #microglia transcriptome across brain regions, aging and #disease pathologies"!
Work led by @lopeskp @JackHumphrey_ #Gijsje and others from #deWitte and #Raj Lab (@towfiqueRaj)
t.ly/pZqQ 1/23
Here, we describe the Microglia Genomic Atlas (#MiGA) project. A genetic and transcriptomic resource of 255 primary human microglia isolated from 4 brain regions of 100 donors with neurodegenerative and psychiatric disease and controls. 2/23 Image
We performed the following analysis: I) age-related (the age of donors range from 21 to 103 y.o! II) brain regional heterogeneity ; III) expression and splicing quantitative trait loci #eQTL & #sQTL. 3/23
Read 23 tweets
Daily Bookmarks to GAVNet 10/11/2020 greeneracresvaluenetwork.wordpress.com/2020/10/11/dai…
The Cure for Aging Might be the Cure for Alzheimer’s - Andreessen Horowitz

a16z.com/2020/10/07/agi…

#alzheimer #cure #aging
Did indigenous Americans and Vikings trade in the year 1000? | Aeon Essays

aeon.co/essays/did-ind…

#americans #vikings #trade
Read 6 tweets
#BHB inhibits #inflammasome activation to attenuate #Alzheimer’s disease #pathology | Journal of #Neuroinflammation |

“Here, we find BHB levels are lower in red blood cells and brain parenchyma of AD patients when compared with non-AD controls... jneuroinflammation.biomedcentral.com/articles/10.11…
...Furthermore, exogenous BHB administration reduced plaque formation, microgliosis, apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc) speck formation, and caspase-1 activation in the 5XFAD mouse model of AD.”
“Taken together, our findings demonstrate that BHB reduces AD pathology by inhibiting NLRP3 inflammasome activation. Additionally, our data suggest dietary or pharmacological approaches to increase BHB levels as promising therapeutic strategies”
Read 3 tweets
21/09 > #Alzheimer : un biomarqueur indiquant une neurodégénérescence identifiée dans l’œil bit.ly/2G1GVfn via @ScienceDaily #LaMethSci
[#Podcast] 2018 > #Alzheimer : année zéro ? bit.ly/2HFdxd4 un #LaMethSci à (ré)écouter via @franceculture !
[L’étude à découvrir] 17/09 > Chaîne légère de neurofilament dans l'humeur vitreuse de l’œil bit.ly/2EqHuPG via @AlzheimersRes #LaMethSci
Read 8 tweets
Today is #WorldAlzheimersDay

#Alzheimer's disease is the most common form of #dementia and may contribute to 60–70% of cases. People with dementia need access to care. Let's ensure the dignity of every person with a #MentalHealth condition is respected

👉bit.ly/2vVsIse
#Dementia is an illness characterized by a deterioration in cognitive function beyond what might be expected from normal ageing.

It is a major cause of disability and dependency among older people 👵👴

👉 bit.ly/2vVsIse

#WorldAlzheimersDay
Reduce your #dementia risk by:
🏃‍♂️ Exercising regularly
🚭 Not smoking
🍺 Avoiding harmful use of alcohol
⚖️ Controlling your weight
🍐 Eating a healthy diet
✅ Maintaining healthy blood pressure, cholesterol & blood sugar levels

👉 bit.ly/2vVsIse

#WorldAlzheimersDay
Read 10 tweets
#Alzheimersday

Aujourd’hui, petit thread informatif sur le travail du #Kinésithérapeute avec un #patient atteint de la #maladie d’#Alzheimer

#TeamKiné
#Alzheimersday

Le #Kiné travaille l’entretien des fonctions d’#équilibre et de #marche du #patient

➡️Exercices aérobics et de coordinations (ex: méthode BIG)
➡️Maintien des capacités de déplacement
➡️Maintien de l’#Autonomie
➡️Limite le risque de #Chute

#TeamKiné
#Alzheimersday

Suite à une sous utilisat’ de certains mouvements des raideurs articulaires/musculaires peuvent apparaître.

➡️ Maintien de la #souplesse des membres
➡️Techniques d’#étirement, #mobilisations spécifiques...
➡️garder une large amplitude de #mouvement

#TeamKiné
Read 5 tweets
Today is #WorldAlzheimersDay 🧠 and this disease has been on #IRBBarcelona's agenda since its start.

@Eduard_puig is one of the committed scientists who recently made an important contribution to the field.
(1/4)
In June, @Eduard_puig, @SoniaCiudad and Natalia Carulla, among others, revealed the specific ensembles of Aβ protein that have the capacity to disrupt the membrane of neurons, causing their death.

➡️bit.ly/3clhW34
#IRBScience #WorldAlzheimersDay
(2/4)
In fact, the @ShorterLab, one of the 🔝groups in protein aggregation, published a review on their work in @TrendsNeuro.

➡️cell.com/trends/neurosc…
#WorldAlzheimersDay
(3/4)
Read 4 tweets
Ensuite, et Dieu que ce fut douloureux... il a bien fallu rendre ton appartement.
3 mois de cartons, le cœur au bord des yeux, à trier ta vie.
A vider, sans te le dire, pour te protéger, ta maison. Là où j’avais grandi. #Alzheimer 2/2
3 mois d’un nouveau marathon. Cartons, sacs, garde-meubles, déchèterie, le bon coin...
Ça m’a valu une névralgie. Codéine et cortisone, la somatisation d’une victime collatérale.
Ton appartement, je l’ai rendu le 31 décembre 2018.
Depuis, une partie de mon cœur est à Garches. Avec toi, et la magnifique équipe qui t’entoure, dans ton Ehpad.
Read 9 tweets
Alzheimer... 9 lettres, un mot et un mal qui m’ont enlevé quelqu’un qui m’était précieux, très précieux.
Ma mère.
Car oui, c’est le propre de cette pute de maladie : tu peux perdre quelqu’un de son vivant.
Thread (1/2, pas mal de choses à dire)👇🏻
#Alzheimer
Ça a commencé il y a 4 ans. 4 ans seulement...
Des absences, des pertes d’équilibre, quelques rendez-vous ratés. 1ers signes, aussitôt repérés, aussitôt ignorés.
Parce que ces 9 lettres, elles font tellement peur que tu ferais tout pour te raccrocher à autre chose. Pour expliquer autrement tout ce bordel.
Les mains sur les yeux, surtout ne pas voir...
Sauf que le monstre, il est déjà là. Dans ta tête, maman, et petit a petit, dans ma vie.
Read 25 tweets
Un hilo sobre la incidencia y últimos avances terapéuticos en la Enfermedad de #Alzheimer.
Un alto en el camino de la pandemia que nos afecta, para poner luz en una de las enfermedades más terribles desde un punto de vista sanitario, personal, social y económico.
1. IMPACTO PROYECTADO
Un total de 131 millones de enfermos para 2050 a nivel mundial y un coste asociado (sanitario+social) cercano a los 2 billones de dólares en 2030. Prevenir, retrasar o detener la enfermedad son retos científicos de este siglo XXI.
ENSAYOS CLÍNICOS EN MARCHA
Hay 121 agentes terapéuticos en ensayos clínicos para abordar la enfermedad de Alzheimer:
- 29 fármacos en fase III
- 65 fármacos en fase II
- 27 fármacos en fase I
Read 7 tweets
Un nuevo biomarcador en saliva que puede facilitar el diagnóstico del #Alzheimer. Sencillo, sensible y específico de la enfermedad. Un avance que esperamos ayudará a centenares de miles de pacientes. geroa.net
ncbi.nlm.nih.gov/pmc/articles/P… Image
Resulta específico de la enfermedad de Alzheimer. Tan solo con una muestra de saliva, y una sencilla medición, muestra un comportamiento riguroso a la hora de detectar aquellos con la enfermedad. Nuestro último trabajo con Valentín Fuster.
thelancet.com/journals/ebiom…
Un momento clave en el que la La FDA (agencia americana) acepta la evaluación prioritaria del fármaco Aducanumab (Biogen) para la enfermedad de #Alzheimer. De aprobarse sería el primer producto que cambiaría el curso de la enfermedad. El diagnóstico será más clave que nunca.
Read 4 tweets
Mi resumen científico de la segunda semana de Agosto (8 al 14) sobre la #COVID19 y el coronavirus.
Un hilo con 10 noticias.
1. Los super-eventos de contagio dependen de 3 factores:
➡️QUIEN: Solo un 10-20% de los infectados serían super-contagiadores
➡️CUANDO: Pico máximo de infectividad (1-2 días tras infectarse). ➡️ DONDE: Lugares cerrados, concurridos y mal ventilados.
2. La empresa Moderna (vacuna ARN) anuncia un precio de 32-37 dólares por dosis para pedidos pequeños (millones de dosis). Entiendo el esfuerzo en I+D, pero sabiendo que han recibido 1000 millones de la administración, el precio me parece abusivo.
Read 12 tweets
358/ #Alzheimers
Question on my cognitive quiz yesterday
How many animals can you name in one minute?
Test your ability. Have someone time you.
Prep for your cognitive exam.😉
@LukeEdwards504 @Gearoidmuar @reelbryanwilson
@julie_eye
My answer below
meandgin.blogspot.com/2020/08/how-ma…
359/ #Alzheimers
I am 9 months into writing my 3rd book on my AZ
I am providing a link that will take you to the draft.
The Pursuit of Happiness w AZ
docs.google.com/document/d/1IU…
@LukeEdwards504 @Gearoidmuar @julie_eye @bmaccullough @reelbryanwilson @FatEmperor @ZKForTre @johnzahorik Image
360/ #Alzheimers
I updated my draft today for the complete 9 months of my third year with AZ.
The free draft can be read at:
docs.google.com/document/d/1IU…
Read 119 tweets
Check out this interview I did w/ @resiapretorius 👉 Resia + team have published dozens of papers detailing how inflammatory products created by #bacteria/#viruses in human blood can drive clotting, red blood cell deformability, vasculature problems etc: microbeminded.com/2020/08/06/int… Image
2/ Conditions studied by Resia and team include #Alzheimer’s + #Parkinson’s. For example they identified toxic gingipain proteins created by oral #pathogen p. gingivalis in the blood of Parkinson’s patients, and showed how the gingipains can increase hypercoagulation ImageImage
3/ I am truly excited about the fact that we are working to send her team #ME/CFS and #PTLDS (chronic #lyme disease) blood samples that they will analyze for many of the same issues 🙌
Read 3 tweets

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