Discover and read the best of Twitter Threads about #Alzheimer

Most recents (9)

J'en vois pas mal dans la presse s'exciter sur :

LE NOUVEAU TRAITEMENT QUI PERMET DE VAINCRE LA MALADIE d'#Alzheimer.

alors je voudrais pas doucher les espoirs, mais on va faire une petite remise en perspective de cette INCROYABLE NOUVELLE •••>
Tout d'abord un point un peu accessoire mais qui a son importance : en 2019 on ne sait toujours pas ce qu'est la maladie d'Alzheimer. On sait ce qu'on constate (une démence qui affecte principalement la mémoire en début de maladie) mais •••>
mais on n'en comprend ni la cause (un probable problème d'anomalie acquise de protéines, sur le même modèle que les protéines prion) ni le mécanisme (probablement une destruction des neurones par accumulation de protéines anormales) •••>
Read 21 tweets
Buenas tardes, hoy es el día mundial de la enfermedad de #Alzheimer por lo que toca repasar los fármacos utilizados en esta forma de demencia. #HilosFarmacologia
Antes de empezar con los tratamientos, unas pinceladas sobre la etiopatogenia: La enfermedad de Alzheimer (EA) es el trastorno neurodegenerativo más prevalente a nivel mundial. Se caracteriza por la degeneración progresiva y específica de las neuronas corticales. La causa...
...de este deterioro se ha relacionado con:
-Formación de placas de proteína beta-amiloide (PBA).
-Formación de ovillos neurofibrilares formados por la fosforilación de la proteína Tau.
Las disfunciones celulares ocasionadas por el metabolismo anormal de estas...
Read 24 tweets
Regarding the #ESCCongress reaction on #DAPAHF I share the enthusiasm of most. For this very reason I made this thread which I hope will raise the curiosity of others.

It shows some shared pathways of medication and #Lifestyle that are obviously not mutually exclusive. (1/4)
Both Pathways ⬆️ Ketones
During #heartfailure mitochondrial oxidative metabolism is compromised and 3-OHB) is ⬆️ In HF pts Ketone bodies appear to be a more efficient alternative fuel and myocardial ketone oxidation as a key metabolic adaptation in the failing human heart. (2/4)
I honestly would not be surprised at all if in a near future we start using Exogenous Ketones, Esters, Salts and even MCT oil as a possible economical therapeutic approach. (3/4)

Ex. Think about #Alzheimer Type III DM & how patients can improve dramatically w diet change.
Read 4 tweets
#Cuivre épisode 2 c'est parti.
Rappel du premier épisode : threadreaderapp.com/thread/1116041… après un peu de chimie et de #reglementation on va rentrer dans le vif du sujet #toxicologie.
D’ailleurs, je m’aperçois que je suis allé un peu vite dans ma démarche.
Petit rappel sur l’évaluation des risques :
Préliminaire, différence entre dangers et risques, je la fais tout le temps celle là mais il faut bien comprendre. #danger : propriété intrinsèque d’une substance, #risque : probabilité d’être exposé à cette substance.
Donc risque = Danger x exposition.
Ceci étant dit : la démarche d’évaluation des risques :
1 – Identification des dangers (par les études, publications, etc…)
2 – Caractérisation du danger : dérivations des doses de références toxicologiques
Read 35 tweets
No need for skepticism of #microbiome + virome involvement in #ME/CFS 👉 But we must factor in the activity of organisms (bacteria, viruses, phages, fungi etc) that often persist + interact outside the gut☝️And many such organisms are not “good” but are pathogens/#pathobionts
In fact, Komaroff asked if anyone has a model for #ME/CFS that links together many findings recently presented at #MECFSatNIH19 👉 Well, that’s what my recent paper on ME/CFS does!...w/ #microbiome + virome activity central to how separate findings connect:frontiersin.org/articles/10.33…
That is b/c 👉 Humans are now understood to be #holobionts: our activity is controlled by the human genome, our microbial/#viral genomes and their respective proteins + metabolites working in tandem (together!): nph.onlinelibrary.wiley.com/doi/full/10.11…
Read 10 tweets
Qué manos más suaves tienes mamá, cómo me mimas, cómo me acaricias, cómo me besas… ¡Y qué bien hueles! Me parece que es la primera vez que te veo, aunque te oigo y es como si te oyera desde siempre. Y el señor de las barbas… ¡también me suena su voz! #HiloDeNochebuena
Dicen que hoy es un día especial, y yo no sé muy bien por qué, pero este sitio se ha llenado de gente. La puerta no para de sonar y cada uno que entra forma una fiesta.
¡Qué ruido, qué jaleo, qué alegría tienen!
Read 57 tweets
1/ In case we needed more reasons for building better cities, the evidence is growing that #mentalhealth is significantly affected by #urbanplanning and #urbandesign ... whether for the better or the worse is up to us ...
2/ Exposure to natural light is linked to better sleep, reduced stress, and better work/school performance bit.ly/2ORgMiw. A well-designed city ensures access to natural light on sidewalks, in public spaces, and inside homes and offices.
3/ Boring streetscapes, with monotonous, feature-less facades and lack of sensory stimulation, can increase sadness, addiction and disease-related stress bit.ly/2OWX5WD
Read 9 tweets
So @Merck’s BACE-1 inhibitor Verubecestat resulted in “near-maximal reduction” of amyloid-beta in cerebrospinal fluid and “modest reduction” in brain amyloid. But it didn’t help even #Alzheimer’s disease, even "mild" Alzheimer's. A few thoughts:
1. Many companies are holding on to the hope that giving #tau- and #amyloid-busting drugs earlier, before Alzheimer's sets in, could prevent the disease. The FDA might even be open to using tau and amyloid as biomarkers to approve #Alzheimers drugs cen.acs.org/articles/96/i9…
2. But if we already know these drugs can lower amyloid-beta levels and *not* stop disease progression, is that really a good idea? I'd love to see the long term studies done, but the idea of drug approval based on biomarkers, and not cognitive markers, seems like a can of worms.
Read 5 tweets
Today is World #Alzheimer's Day.
Alzheimer's disease is the most common cause of #dementia & may contribute to 60–70% of cases
#Dementia is a major cause of disability among older people bit.ly/2xxKjbF
There are nearly 10 million new cases of #dementia every year - that's one case every 3 seconds bit.ly/2xxKjbF
Read 9 tweets

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