Discover and read the best of Twitter Threads about #Autophagy

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Tonight on #MitoMonday we briefly highlight and remember the life and works of Dr. Beth Levine, A giant in the field of autophagy research, who sadly passed away recently. #LateNightWithTheRutterLab #WomenInSTEM #Autophagy
Dr. Beth Levine was born in Newark, New Jersey in 1960. She obtained a degree in French studies from @BrownUniversity in 1981. She then earned her medical degree from @WeillCornell in 1986, and was a resident at @MountSinaiNYC hospital in internal medicine until 1989. 2/
In 1989 she joined the lab of Dr. Diane Griffen at @JohnsHopkins as a postdoc, working on infectious diseases and the neurobiology of viral pathogens. She then joined @Columbia in 1992, where she served as the Director of virology research from 1994-2004. 3/
Read 9 tweets
1 approach to understanding #covid19 infection is to examine co-morbidities & ask what's common?

Most prevalent Cov19 co-morbs:

1)↗️age
2)Hypertension
3)Diabetes
4)Cardiovascular disease
5)Kidney disease
6)Chronic respiratory disease (esp COPD)
8)Cancers
9)BMI>40
10)♂️>♀️ ImageImageImageImage
2/
These are diverse diseases & increasing age technically not a disease at all. However, there is at least 1 factor in common among all of the co-morbidities identified thus far:

INFLAMMATION
3/
A survey of the co-morbidities revealed another commonality; a close association w/ dysregulation of the pro-inflammatory, neutrophil-recruiting cytokine, IL-17A.

IL-17A is made by multiple immune cell types, including lung-resident innate lymphoid cells (ILC3s).
Read 35 tweets
!!!NEW!!! A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress #autophagy #ER_phagy #ER_Literature #ufmylation biorxiv.org/content/10.110… a thread 1/8
Via a screen in Arabidopsis, we identified C53, an #IDR containing highly conserved protein, as a direct #ATG8 interactor. It interacts 8/9 arabidopsis, 1/2 marchantia and 2/6 human ATG8s via the LDS 2/8
Using native mass spec, ITC, SPR and cell biology, we showed that it binds ATG8 via a non-canonical AIM, that we named Shuffled AIM (sAIM)- IDWG 3/8
Read 8 tweets

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