Discover and read the best of Twitter Threads about #B11248
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NIAID investigators and collaborators at @ImmunoScape and @JHUcovidplasma recently published a study in @jclinicalinvest characterizing #Tcell responses in people who recover from #SARSCoV2 infection. jci.org/articles/view/…
T cells are a type of white blood cell part of the immune system & may allow for long-term protection against #SARSCoV2. Learning more about natural infection can help guide development of improved treatments and vaccines.
The researchers found that the majority of CD8+ T cells targeted internal and non-structural sites on viral proteins (epitopes), indicating possible targets for next-generation vaccines.
Der Kampf um R– ich möchte einmal versuchen darzustellen, wie bei einer Epi-/#Pandemie letztlich dieser eine Wert „R“ bestimmt, ob und wie sich die Infektion ausbreitet und wie beide Seiten– Mensch *und* Virus– versuchen, R zu ihren jeweiligen Gunsten zu verschieben! #COVID19
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Jeder, der mit dem Virus infiziert kann es theoretisch auf jemand anderen übertragen und damit zur Verbreitung beitragen. Bei wem das zu welchem Zeitpunkt wie wahrscheinlich ist, hängt von vielen Faktoren ab. Ganz klar: die Menge an „lebensfähigem“ Virus in den oberen…
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Atemwegen ist maßgeblich für die Möglichkeit, jemand anderen anzustecken, was aktuell nun auch in einer großen Studie gezeigt wurde⬇️. Die sog. Viruslast ist bei #SARSCoV2 übrigens bereits kurz (~1d) *vor* Einsetzen der Symptome sehr hoch, wodurch dieser Zeitraum um den…
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BREAKING—A new #SARSCoV2 variant (aka B.1.1.248) identified by Japan 🇯🇵 in ✈️pax from Brazil 🇧🇷. This new one has both the more infectious N501Y mutation (not affect vaccine), as well as the disruptive E484K mutation that escapes neutralizing antibodies.🧵
bloomberg.com/news/articles/…
bloomberg.com/news/articles/…
2) Why are we so worried about this one? Because like the SA B1351 variant, this new one also has the E484K mutation. In a recent study by @jbloom_lab, E484 mutation (inside the #SARSCoV2’s spike’s critical receptor binding domain) seemed to escape neutralizing antibodies—bad.
3) More on the E484K mutation. Escaping neutralizing antibodies could mean some convalescent plasma, some antibody drugs, and maybe even vaccines could be disrupted a little. But need more studies to prove it
Meanwhile in #France,
"the peak of this second wave is over"
(according to the President in his Adress to the Nation):
"the peak of this second wave is over"
(according to the President in his Adress to the Nation):
Wait... "the peak is over" doesn´t mean "it´s back to normal"!
Confinement will only fall on December 15,
if there´s less than 5.000 new cases a day.
(today it´s ~9.000).
France is disappointed.🙁
Although they certainly can make it happen.
Confinement will only fall on December 15,
if there´s less than 5.000 new cases a day.
(today it´s ~9.000).
France is disappointed.🙁
Although they certainly can make it happen.
Meanwhile in #Switzerland:
(excess mortality of the second wave is significant)
Good news: fastest decrease in infections happens in the worst hit areas now.
(excess mortality of the second wave is significant)
Good news: fastest decrease in infections happens in the worst hit areas now.
As #COVID19 cases are found to spread, #Melbourne (city of ~5 million) tries to contain them by going into #Lockdown.
(The interview features the idea of a dedicated #Quarantine building - that would actually help, I guess)...
(The interview features the idea of a dedicated #Quarantine building - that would actually help, I guess)...
"People acting as if the pandemic was over was 'not the answer, it is part of the problem' ".
"The virus had leaked from postcodes already under the stay-at-home orders to other parts of #Melbourne."
(and beyond, it is feared).
"The virus had leaked from postcodes already under the stay-at-home orders to other parts of #Melbourne."
(and beyond, it is feared).
Due to #Melbourne's outbreak, neighbouring South Australia is about to completely close it's borders to #Victoria.
(Nearly) no exceptions. And those essential few who are allowed in, will have to wear facemasks the entire time...
(Nearly) no exceptions. And those essential few who are allowed in, will have to wear facemasks the entire time...
Vorpommern-Greifswald district (where rejections of #Gütersloh residents took place, yesterday)
has specific rules:
"Those who return from international risk areas (out of Germany) or whose Corona-Warning App has alerted them, need to report to authorites"
kreis-vg.de
has specific rules:
"Those who return from international risk areas (out of Germany) or whose Corona-Warning App has alerted them, need to report to authorites"
kreis-vg.de
In fact, Mecklenburg-Vorpommern's Corona-ordinance really prohibits entry of people from international risk areas AND german risk areas as well.
It's just not prominently featured on their websites.
(Overlooked that myself, hence deleted earlier tweet)
landesrecht-mv.de/jportal/portal…
It's just not prominently featured on their websites.
(Overlooked that myself, hence deleted earlier tweet)
landesrecht-mv.de/jportal/portal…
People from #Gütersloh district may have to scrap all their holiday plans anyway...
An official #Lockdown is just being announced for the entire district.
(for one week, as of now)
An official #Lockdown is just being announced for the entire district.
(for one week, as of now)
