https://twitter.com/CrabbBrendan/status/1596253183302828032

https://twitter.com/CrabbBrendan/status/1596253183302828032

@Karl_Lauterbach

@Sante_Gouv

Eric Feigl-Ding

@DrEricDing

💡2x BOOSTER SAVES LIVES—New CDC data shown today shows that 2 booster shots ⬇️lowered #COVID19 death rates by 📌14x (purple line) vs unvaccinated—plus amazingly, 2 boosters ⬇️deaths 📌3x vs 1 booster alone (blue). CDC soon to approve #BA5/4 booster software update—get it please!

2) What shocks me is how people just hand wave “oh I don’t need 3x lower risk of dying with another shot” as if it’s nothing. Jeez people. Also vaccines lower risk of seeing #LongCovid too. Don’t be so stubborn.

3) New #BA5 and #BA4-targeting coronavirus booster shots has now gotten EUA from the FDA for all age 12+… thus second boosters now eligible for those 12-49 finally! CDC advisors voting soon. Rollout imminent within days. Please get boosted. Hope it’ll get EUA for kids <12 soon.

Read 4 tweets

Eric Feigl-Ding

@DrEricDing

Incoming—CDC vaccine advisers expected to vote Thursday on updated #BA5 variant boosters. New shots likely available within days. This is the booster I’m waiting for.

P.s. This updated booster is basically the same as the original just slightly modified spike configuration for BA5. I don’t need to see a new Phase 3 trial of 30,000 people for small software updates. Hence lab studies showing superiority over the old 1.0 version is okay. Get it.

3) to be clear— this variant update lab method is what we do with influenza vaccines yearly (instead of launching major new flu trials yearly). And I’m confident it will be similar with this BA5 mRNA vaccine update from the Wuhan 1.0.

Read 9 tweets

Boo Soon Yew 🇲🇾

@BooSoonYew67

Now it's been a while since I've talked abt #COVID19 in #Malaysia (except a month back abt cases among school kids in Penang).. but if ever anyone wants to hv an academic understanding of why there is a resurgence of cases.. here it is.. Point mutation !!

https://twitter.com/RolandBakerIII/status/1549188403245092865?t=WfBt_pAw4fnibViN30Tvdw&s=19

@RolandBakerIII

This is the start of @RolandBakerIII 's thread on the mechanism of how the BA.4 & BA.5 subvariants of the #Omicron evade action of antibodies..

https://twitter.com/RolandBakerIII/status/1549184340784926721?t=WfBt_pAw4fnibViN30Tvdw&s=19

A look at recent cases in the USA, showing in no uncertain terms about the dominance of #COVID19 cases from the #BA4 & #BA5 ..

https://twitter.com/GeorgeMonks11/status/1549425938005360651?t=FTOciysrXKRletZcSQMPEA&s=19

Read 14 tweets

𝐏𝐌𝐏 🌐 𝐌𝐚𝐠𝐚𝐳𝐢𝐧𝐞

@PMPmagToday

@PMPmagToday

📆#LatestCOVID @PMPmagToday
▫#Zoe COVID Study estimates 345,865 cases (+1.9% in a week)
▫7-day estimate: 2,427,165 cases in a week (+8.5%)
▫On average, at least 346,738 people are still infected by #COVID19 every day in the UK

🙈🙊🙉#CovidIsNotOver

→ pmp-magazine.com/2022/07/15/lat…

@PMPmagToday

📆#LatestCOVID @PMPmagToday

#Zoe Estimate (15-Jul)

𝗦𝘆𝗺𝗽𝘁𝗼𝗺𝗮𝘁𝗶𝗰 𝗖𝗮𝘀𝗲𝘀
24h—345,865 (+1.9%)
7d—2,427,165 ↗️
28d—8,063,909 ↗️

𝗗𝗮𝗶𝗹𝘆 𝗔𝘃𝗲𝗿𝗮𝗴𝗲
346,738 ↗️

𝗖𝘂𝗿𝗿𝗲𝗻𝘁 𝗦𝘆𝗺𝗽𝘁𝗼𝗺𝗮𝘁𝗶𝗰
4,556,818 ↗️

🙈🙊🙉#CovidIsNotOver

→ pmp-magazine.com/2022/07/15/lat…

@PMPmagToday

📆#LatestCOVID @PMPmagToday

@ONS Estimate (as of 7-Jul)

𝗖𝗮𝘀𝗲𝘀
7d—3,498,700 (+28.9%) ↗️
28d—11,662,600 ↗️

𝗗𝗮𝗶𝗹𝘆 𝗔𝘃𝗲𝗿𝗮𝗴𝗲
499,8148 ↗️

🙈🙉🙊 #CovidIsNotOver

→ pmp-magazine.com/2022/07/15/lat…

Read 11 tweets

Antoine FLAHAULT

@FLAHAULT

1/4 - “On peut raisonnablement penser que le pic de la vague de contaminations est passé en France et passe actuellement sur une grande partie de l’Europe. L’expérience portugaise nous permet d’appuyer cette analyse.” leparisien.fr/societe/sante/…

2/4 - Si la France suit la dynamique portugaise de sa récente vague #BA5, alors le pic de mortalité pourrait être quinze jours après celui des contaminations, soit en France début juillet, avec un pic d’hospitalisations le précédant de quelques jours.

3/4 - Au Portugal, la mortalité #COVID19 enregistrée sur quatre mois, début avril - fin juillet, devrait être de 3000 décès. Si l’on poursuit l’analogie, en France, entre mi-mai et mi-septembre, on pourrait enregistrer 20’000 décès #COVID19.

Read 6 tweets

Antoine FLAHAULT

@FLAHAULT

1/9 - “Hospital admissions are rising across Europe and the US as highly transmissible #COVID19 variants drive infections, but the resulting illness is less likely to be severe or cause death than in previous waves, according to the FT and health experts.”
ft.com/content/f4794a…

2/9 - “The number of new #COVID19 admissions has grown by 40 per cent in the last week in France, 34 per cent in England and more than 20 per cent in several other European countries. The wave has been fuelled by the #BA5 #Omicron sub-variant.”

3/9 - “The rate of increased hospital admissions in the US is currently slower than in Europe at 6%. This reflects the decline of the #BA2 variant in the US. But as the #BA5 variant becomes dominant, the overall rate of growth is likely to accelerate.”

Read 9 tweets

Maria Van Kerkhove

@mvankerkhove

Reality check👇

#COVID19 deaths globally are at a similar level to March 2020. While deaths are now much lower than they have been at their peaks over the last 2.5 yrs, we must remember that in 3/20, we knew very little about this virus & we had no treatments & no vaccines
1/🧵

Now in July 2022, we have several life saving interventions that we are not utilising effectively nor consistently globally & deaths should be far lower at this point in the pandemic

It’s not over & are playing with fire by letting this virus circulate at such intense levels
2/

@WHO

Among #Omicron lineages, #BA5 & #BA4 continue to rise globally.

BA.5 has been detected in 83 countries, with prevalence ⬆️ from 37% to 52% from 19 to 25 June. The rate of BA4 ⬆️ is not as high as BA5.

3/ @WHO

Read 7 tweets

Antoine FLAHAULT

@FLAHAULT

1/9 - “A surge in #COVID19 hospital admissions driven by the #BA5 of #Omicron, accompanied by the inability of vaccines to prevent reinfection, has prompted health policymakers to rethink their approach to boosters.”
ft.com/content/4f71ac…

2/9 - “Research into immune imprinting, whereby exposure to the virus via either infection or vaccination determines an individual’s level of protection, is now driving the debate over the make-up of #COVID19 vaccines.”

3/9 - “Immunologists say that, >2y into the pandemic, people have acquired very different types of immunity to the #SARSCoV2, depending on which strain or combination of strains they have been exposed to — leading to big diff in #COVID19 outcomes between indiv and countries.”

Read 9 tweets

Dr K Fearnley

@fearnley_k

@BBC

1/ Dangerous spread of misinformation by @BBC.

Do not be vaxed relaxed. Triple vaccination and prior infection with omicron #BA1 does not offer protection omicron variants #BA4 and #BA5 - which are currently driving the new wave of infection in the UK. 🧵

https://twitter.com/mdfacep/status/1541797146009079809

2/ #BA5 resists and escapes neutralising antibodies induced by triple-dose vaccination & antibodies induced by prior omicron (#BA1) infection.

https://twitter.com/mdfacep/status/1541797146009079809

3/ Please do all you can to prevent (re)infection. #COVIDisAirborne which means infectious particles are carried in the air we breathe. To protect yourself wear a good-fitting #FFP2 or #FFP3 mask 😷 especially when in indoor public spaces.

Read 5 tweets

Dr K Fearnley

@fearnley_k

https://twitter.com/VPrasadMDMPH/status/1542203742568689664

1/ Bad advice. Do not be vaxed relaxed. Omicron variants #BA4 and #BA5 - which are currently driving the new wave of infection, - resist & escape neutralizing antibodies induced by triple-dose vaccination & antibodies induced by prior omicron (#BA1) infection. 🧵

https://twitter.com/VPrasadMDMPH/status/1542203742568689664

https://twitter.com/MdFacep/status/1541797146009079809

2/ Triple vaccination & prior omicron infection with #BA1 confer no protection against the new variant.

https://twitter.com/MdFacep/status/1541797146009079809

3/ Please ignore notorious Covid-minimiser, Prasad.

‘93-98%’ of people will not get #COVID19 if they wear a good-fitting #FFP2 or #FFP3 mask.

(Re)infection is not ‘inevitable’ and should be avoided. Continue to protect yourself.

Read 6 tweets

Maria Van Kerkhove

@mvankerkhove

@WHO

Globally, #COVID19 cases has increased for the 3rd consecutive week with >4.1million cases reported to @WHO (18%⬆️ compared to previous week). During the same week, 8,552 fatalities were reported.

We @WHO know both are underestimates and both cases & deaths are too high.

1/🧵

@WHO

Global hot spots can be seen in these figures from our latest @WHO #COVID19 Weekly Epidemiological Update available here:

who.int/publications/m… 2/

In this edition we also provide:
↗️An update on the circulating #SARSCoV2 variants of concern
↗️ A special focus on relative vaccine effectiveness

#Omicron is still dominant: BA.2 represents 25% of sequences, BA.2.12.1 11%, BA.4 12%, & BA.5 43%. #BA4 & #BA5 reports are ⬆️

3/

Read 5 tweets

Eric Feigl-Ding

@DrEricDing

📍NEW DOMINANCE of “ESCAPE ARTIST” Variants #BA5 & #BA4–together topping 52% of all strains in the US, all while #BA2 family going extinct. ➡️BA5&4 are highly evasive against past immunity—matches rise in #COVID19 hospitalization in US & many countries.🧵 covid.cdc.gov/covid-data-tra…

2) this is why FDA has recommended for updates booster shots— The panel’s vote paves the way for F.D.A. to push manufacturers to make reformulated boosters in time for Biden WH to offer them later this year, before an expected winter surge of the virus.
nytimes.com/2022/06/28/us/…

https://twitter.com/DrEricDing/status/1541418780210995200

3) #BA5 has begun causing havoc in hospitalizations worldwide in many countries. Especially recently in Portugal that had a wave of hospitalization that neared it’s winter peak. UK is now being squeezed by BA5/4 too. 👇

https://twitter.com/DrEricDing/status/1541418780210995200

Read 8 tweets

𝐏𝐌𝐏 🌐 𝐌𝐚𝐠𝐚𝐳𝐢𝐧𝐞

@PMPmagToday

@PMPmagToday

📆#LatestCOVID 🦠 @PMPmagToday
#UKHSA Report (as of 28-Jun)

🧪#COVID CASES
▫7d—119,919 ↗️

🏥ADMISSIONS
▫7d—8,158 ↗️

🏥PATIENTS
▫24h—8,332 ↗️

🛌ICU
▫7d—1,295 ↗️

🕯️DEATHS
▫7d—410 ↗️

🤕#LONGCOVID
▫2 million people 🚨

🙈🙊🙉 #CovidIsNotOver

→ pmp-magazine.com/2022/06/28/lat…

@PMPmagToday

📆#LatestCOVID @PMPmagToday
#Zoe Estimate (as of 26-Jun)

𝗦𝘆𝗺𝗽𝘁𝗼𝗺𝗮𝘁𝗶𝗰 𝗖𝗮𝘀𝗲𝘀
24h—275,706 ↗️
7d—1,762,508 ↗️
28d—4,843,850 ↗️

𝗗𝗮𝗶𝗹𝘆 𝗔𝘃𝗲𝗿𝗮𝗴𝗲
251,787 ↗️

𝗖𝘂𝗿𝗿𝗲𝗻𝘁 𝗦𝘆𝗺𝗽𝘁𝗼𝗺𝗮𝘁𝗶𝗰
3,057,628 ↗️

🙈🙊🙉#CovidIsNotOver

→ pmp-magazine.com/2022/06/28/lat…

@PMPmagToday

📆#LatestCOVID @PMPmagToday
#ONS Estimate (as of 18-Jun)

𝗖𝗮𝘀𝗲𝘀
7d—1,739,100 ↗️
28d—5,098,400 ↗️

𝗗𝗮𝗶𝗹𝘆 𝗔𝘃𝗲𝗿𝗮𝗴𝗲
248,443 ↗️

🙈🙉🙊 #CovidIsNotOver

→ pmp-magazine.com/2022/06/28/lat…

Read 11 tweets

James Cintolo, RN FN CPT 🏥 📷 🎙️

@healthbyjames

🧵1/A new cohort study using de-identified data from South Africa to measure the severity of Omicron BA1 VS new #BA4 & #BA5 subvariants, found that of ~190K BA1 and ~4K BA4+BA5 patients, severe hospitalization & death from all variants was identical (aHR 1.01, 95% CI: 0.92;1.12)

2/Moreover, those with previous infection were conferred nearly 2X less risk of severe disease and death from Omicron BA1, BA4 & BA5 (aHR 0.19,95% CI: 0.16;0.22) VS those double vaccinated (aHR 0.58, 95% CI: 0.54;0.63) implying that vaccination was less effective than infection

3/ Finally, prior #Covid infection provided nearly equal protection against severe disease and death from all Omicron subvariants (aHR 0.19, 95% CI: 0.16;0.22) VS being triple vaccinated (aHR 0.24, 95% CI: 0.15;0.39)

Read 5 tweets

𝐏𝐌𝐏 🌐 𝐌𝐚𝐠𝐚𝐳𝐢𝐧𝐞

@PMPmagToday

@PMPmagToday

📆#LatestCOVID 🦠 @PMPmagToday
#UKHSA Report (as of 27-Jun)

🧪#COVID CASES
▫7d—114,936 ↗️

🏥ADMISSIONS
▫7d—7,809 ↗️

🏥PATIENTS
▫24h—7,822 ↗️

🛌ICU
▫7d—1,215 ↗️

🕯️DEATHS
▫7d—398 ↗️

🤕#LONGCOVID
▫2 million people 🚨

🙈🙊🙉 #CovidIsNotOver

→ pmp-magazine.com/2022/06/27/lat…

@PMPmagToday

📆#LatestCOVID @PMPmagToday
#Zoe Estimate (as of 25-Jun)

𝗦𝘆𝗺𝗽𝘁𝗼𝗺𝗮𝘁𝗶𝗰 𝗖𝗮𝘀𝗲𝘀
24h—270,864 ↗️
7d—1,686,923 ↗️
28d—4,682,174 ↗️

𝗗𝗮𝗶𝗹𝘆 𝗔𝘃𝗲𝗿𝗮𝗴𝗲
240,989 ↗️

𝗖𝘂𝗿𝗿𝗲𝗻𝘁 𝗦𝘆𝗺𝗽𝘁𝗼𝗺𝗮𝘁𝗶𝗰
2,960,484 ↗️

🙈🙊🙉#CovidIsNotOver

→ pmp-magazine.com/2022/06/27/lat…

@PMPmagToday

📆#LatestCOVID @PMPmagToday
#ONS Estimate (as of 18-Jun)

𝗖𝗮𝘀𝗲𝘀
7d—1,739,100 ↗️
28d—5,098,400 ↗️

𝗗𝗮𝗶𝗹𝘆 𝗔𝘃𝗲𝗿𝗮𝗴𝗲
248,443 ↗️

🙈🙉🙊 #CovidIsNotOver

→ pmp-magazine.com/2022/06/27/lat…

Read 10 tweets

Raj Rajnarayanan

@RajlabN

#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

46.66% BA.2.12.1**,
23.33% BA.5^^,
12.15% BA.4^^,
7.64% BA.2,
4.24% BA.5.1^^,
1.29% BA.2.9 and
1.17% unassigned

**S:L452Q; ^^S:L452R/F486V

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 6/27/22

#OmicronVariantUpdates #UnitedStates 06/27/22

Top 5 lineages:
BA.2.12.1, ⬇️ (Spike: L452Q)
BA.5, ⬆️ (Spike: L452R)
BA.4 ⬆️ (Spike: L452R)
BA.2 ⬇️
BA.5.1 ⬆️👀 (Lineage prevalent in #Portugal)

* includes recently designated BA.2.x.y and undesignated BA.2s

#SARSCoV2 lineages in USA (#15DayTrends)

Circulating #BA5*/#BA4* sub-lineages:
BA.5, BA.4.1, BA.5.2.1, BA.5.1, BA.4, BA.5.2, BA.5.3.1, BE.1, BF.1, BA.5.3

Assignments via: #Nextclade #PANGO - clades.nextclade.org

Read 13 tweets

Evan Blake

@EvanBlake17

The #COVID19 pandemic is once again spiraling out of control, driven by the highly contagious and immune-evading Omicron #BA4 & #BA5 subvariants. North America, Europe, Brazil & Australia are at the epicenter of the latest global surge. #CovidIsNotOver 1/ wsws.org/en/articles/20…

The global 7-day average of daily new cases now stands at 661,420, a 42% increase since the trough in late May! Official new infections are rising despite the dismantling of surveillance and reporting, with test positivity rates rising in each of these countries and regions. 2/

https://twitter.com/EnemyInAState/status/1541221753564925952

Wastewater in Spain is at record levels! This key metric is rising rapidly in many countries. The sudden rise in test positivity rates means that unreported infections are occurring faster than those being documented by public health departments. 3/

https://twitter.com/EnemyInAState/status/1541221753564925952

Read 22 tweets

Eric Feigl-Ding

@DrEricDing

@jburnmurdoch

⚠️Very worried about #BA5 causing #COVID19 hospitalization surges everywhere it goes—bad it’s very past-immunity-evasive. Portugal hit 80-90% of its old hospitalization peak recently. UK hospitals strained to the brink now too. Bad trends many in places.🧵

HT @jburnmurdoch

@JPWeiland

2) based on models, #BA5 and it’s close cousin #BA4, also past-immunity evasive, is surging so fast, it will likely be 50% of all #SARSCoV2 strains in the Us this week—and soon displacing all other past strains.

HT @JPWeiland

https://twitter.com/Antonio_Caramia/status/1541113376448958468

3) Why do we need to look at Portugal? It’s a highly vaccinated country, yet #BA5 has completely overwhelmed it. Vaccines work overall, but if a virus spreads unchecked without OTHER MITIGATIONS, vaccines not enough alone. We need vaccines+ PLUS other mitigations.

https://twitter.com/Antonio_Caramia/status/1541113376448958468

Read 12 tweets

Antoine FLAHAULT

@FLAHAULT

1/8 - “#COVID19 infections continue to surge across the UK, with the number of people in England estimated to have the virus jumping 20 per cent to 1.3mn in the past week, according to the latest official survey.”
ft.com/content/825af0…

2/8 - “The latest Covid wave has hit Scotland hardest. About one in 20 people or 4.76 per cent of the population in Scotland had #COVID19 — up 40 per cent on the previous week.”

3/8 - “These increases are largely driven by the #Omicron #BA4 and #BA5 variants . . . In England, infections increased across all age groups, with the lowest level of infection seen in school aged children.[…] #BA4 accounts for 22% and #BA5 for 39% of new cases.”

Read 8 tweets

Raj Rajnarayanan

@RajlabN

#COVID19 #VariantDashboard - #UnitedStates

TOP lineages (15-DAY TRENDS):

50.65% BA.2.12.1**,
19.90% BA.5^^,
10.46% BA.4^^,
9.83% BA.2,
3.30% BA.5.1^^,
1.21% BA.2.3 and
1.09% BA.2.9

**S:L452Q; ^^S:L452R/F486V

Tracker: tinyurl.com/mryj4uu7
#OmicronUpdates 06/26/22

#OmicronVariantUpdates #UnitedStates 06/26/22

Top 5 lineages:
BA.2.12.1, ⬆️ (Spike: L452Q)
BA.5, ⬆️ (Spike: L452R)
BA.4 ⬆️ (Spike: L452R)
BA.2 ⬇️
BA.5.1 ⬆️👀 (Lineage prevalent in #Portugal)

* includes recently designated BA.2.x.y and undesignated BA.2s

#SARSCoV2 lineages in USA (#15DayTrends)

Circulating #BA5*/#BA4* sublineages:
BA.5, BA.4.1, BA.5.2.1, BA.5.1, BA.4, BA.5.3.1, BA.5.2, BE.1, BA.5.3, BF.1

Read 14 tweets

Raj Rajnarayanan

@RajlabN

Tracking #BA4* and #BA5* #Omicron #Sublineages over time

This tracker includes only sequences with signature mutations👇

Sequence count: 56,087
BA.4*: 17,971
BA.5*: 38,116

Tracker: public.tableau.com/app/profile/ra…
Updated 6/25/2022

BA.4*/BA.5* Global Hotspots

#UnitedKingdom, #Israel, #Denmark, #UnitedStates, #Germany, #Belgium, #France, #Australia, #Italy, #Ireland, #Austria, #Netherlands, #Singapore, #Mexico, #Spain, #NewZealand, #Canada, #Indonesia

Tracker: public.tableau.com/app/profile/ra…

#15DayTrends

Status of #BA4/#BA5 in #Europe - #15DayTrends

BA.5 is surging ahead...

Read 8 tweets

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