Discover and read the best of Twitter Threads about #BMT

Most recents (2)

1/ Excited to share how T cell therapies kill #leukemia!! multi-omics + new #computational #singlecell tools for longitudinal analysis 👉unexpected answer!…

*👏* @elhamazizi! 🙏 @dpeer Cathy Wu @MDAndersonNews @CPRITTexas @ColumbiaBME @sloan_kettering
2/ We studied donor lymphocyte infusion (DLI) - an #Immunotherapy for relapsed #leukemia after #BMT & the #og of #celltherapy. Previously, we showed DLI reversed T cell exhaustion - but didn't know why/how/which T cells were responsible...…
3/ To address these ?'s, we modeled intraleukemic T cell dynamics by integrating longitudinal, multimodal data from ~100K T cells (!) during response (R) or resistance (NR: nonresponder) to DLI.
Read 18 tweets
How did hematopoietic stem cell transplantation (BMT) develop? A procedure that is so widely used now and have led to the cure of many hematologic disorders has evolved over the last 70 years. This 🧵 is a short historical overview of #BMT
After Word War II, and specifically after the atomic bomb was dropped on Hiroshima and Nagasaki in 1945, there was an interest in funding treatments for radiation sickness that caused bone marrow failure and led to the death of many.
In 1949, L.O. Jacobsen demonstrated that mice can be protected from otherwise lethal effects of body irradiation by shielding the spleen (the spleen in mice contains hematopoietic tissue)
Read 25 tweets

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