Discover and read the best of Twitter Threads about #BREAKTHROUGH
Most recents (24)
#OTD 1915 #GorliceTarnow | All units for the upcoming offensive were now in position, with Von Mackensen's 11. Armee deployed to the SW of #Gorlice with Korps Kneussl & the XLI Reserve Korps to the west of the city. The A-H VI Korps followed & the Garde Korps was on the 25/X
northern flank. The two Div of X Korps were assembling in reserve. Joseph Ferdinand's 4. Armee was to the north of 11. Armee with IX Korps deployed on either side of #Gromnik, whereas Gruppe Roth's two divisions were to its north. The most northern formation Gruppe 26/X
Stöner-Steiner, made up of various Landsturm units and a few battalions assigned from 1. Armee. Joseph Ferdinand's reserve was a single brigade from XII Korps. The deployment and movement since the decision for the offensive in this sector of the Eastern front were 27/X
#Marktwirtschaftstotalitarismus: "Der Hauptgeschäftsführer der Bundesvereinigung der Arbeitgeberverbände (#BDA), Steffen Kampeter, fordert längere #Arbeitszeiten – und mehr Lust auf #Arbeit. 'Wir brauchen mehr Bock auf Arbeit', ..."
tagesspiegel.de/politik/wir-br… #AgeOfDeception
tagesspiegel.de/politik/wir-br… #AgeOfDeception
"In den #Schulen müsse Leistung wieder eine größere Rolle spielen, forderte der Verbandsvertreter. '#Leistung ist was wert. Mehr noch: #Wir brauchen Leistung.“
"'Ich befürchte, die ganze #Gesellschaft hat durch staatliche #Fürsorge, durch Rettungsprogramme, Doppel-Wumms und alle möglichen Formen der staatlichen Abfederung vergessen oder verlernt, dass das #Geld auch erwirtschaftet werden muss.“
ZINC NETWORK officers:
Scott Brown - Deputy Chief of Staff at CHIMES COMMS (2009-2012) zincnetwork.com/person/scott-b…
Robert Elliott, CEO - worked for Endemol, WARNER BROS
…te.company-information.service.gov.uk/company/112598
Scott Brown - Deputy Chief of Staff at CHIMES COMMS (2009-2012) zincnetwork.com/person/scott-b…
Robert Elliott, CEO - worked for Endemol, WARNER BROS
…te.company-information.service.gov.uk/company/112598
In 2012 Scott Brown became CEO of #Breakthrough Media and started Zinc Network with bestie Robert Elliott
Looking a little closer at CHIMES gives us further insight into London, specifically.. HAMPSTEAD..
in-this-together.com/expose-network…
Looking a little closer at CHIMES gives us further insight into London, specifically.. HAMPSTEAD..
in-this-together.com/expose-network…
'Lord Tim Bell began his career in 1959 at Colman Prentis and Varley & after stints with Hobson Bates and Geers Gross, he helped form Saatchi & Saatchi in 1970
He later co-founded Bell Pottinger which became CHIME Comms when it was floated on the London stock exchange'
He later co-founded Bell Pottinger which became CHIME Comms when it was floated on the London stock exchange'
People are being reinfected immediately again after #Omicron infection!!
A new study shows that immunity based upon “mild" Omicron infection is weak for Omicron reinfection, and limited for cross immunity to Delta infection. 1/
A new study shows that immunity based upon “mild" Omicron infection is weak for Omicron reinfection, and limited for cross immunity to Delta infection. 1/
Overall, immunity from Omicron infection is much lower than the immunity from Delta infection, correlated with the severity of infection. 2/
What does that mean?
Unless you get a severe infection with all of its consequences you also don’t get immunity from having another infection.
And recall even immunity from severe infection wanes rapidly in a few months. 3/
Unless you get a severe infection with all of its consequences you also don’t get immunity from having another infection.
And recall even immunity from severe infection wanes rapidly in a few months. 3/
🇬🇧 Huge successes and major setbacks after the vote on the #DigitalServicesAct. We won backing for a right to use services anonymously, but there will be mandatory 📱number registration for adult content creators.
Find out who supported and who opposed your digital rights 🧵⬇
Find out who supported and who opposed your digital rights 🧵⬇
Personal information of millions of EU citizens is hacked and leaked again and again, fuelling cybercrime.
We were now able to secure a majority for a right to use and pay for digital services anonymously in the #DigitalServicesAct!
#Breakthrough
We were now able to secure a majority for a right to use and pay for digital services anonymously in the #DigitalServicesAct!
#Breakthrough
Internet corporations use unreliable #uploadfilters against supposedly illegal content - with much collateral damage. The majority won‘t even limit automated censorship to content that is manifestly illegal irrespective of its context.
#rejected
#rejected
1/
New research shows that only 10% #Omicron cases are in ppl who have gotten #COVID19 #Booster.
This may be MISINTERPRETED as:
"Only 10% of people w/ #BoosterDose get #OmicronVariant"
OR
#BoosterShots are 90% effective"
Not that simple! READ ON!
medrxiv.org/content/10.110…
New research shows that only 10% #Omicron cases are in ppl who have gotten #COVID19 #Booster.
This may be MISINTERPRETED as:
"Only 10% of people w/ #BoosterDose get #OmicronVariant"
OR
#BoosterShots are 90% effective"
Not that simple! READ ON!
medrxiv.org/content/10.110…
2/
First, this is NOT a critique of the study (currently a pre-print).
Researchers at @MethodistHosp who did this provided a VERY valuable piece of info and are not making any inappropriate claims. Great work!
It's just that it's easy for public/media to misinterpret results!
First, this is NOT a critique of the study (currently a pre-print).
Researchers at @MethodistHosp who did this provided a VERY valuable piece of info and are not making any inappropriate claims. Great work!
It's just that it's easy for public/media to misinterpret results!
3/
Paper reports on a total of 1313 #OmicronVariant cases in the Houston, TX area.
See table below:
~49% of cases in those not vaccinated (0 or 1 does)
~51% are #BREAKTHROUGHS.
Of those #Breakthrough cases,
535 cases w/ 2 #vaccine doses
140 cases w/ 3 doses (i.e., booster)
Paper reports on a total of 1313 #OmicronVariant cases in the Houston, TX area.
See table below:
~49% of cases in those not vaccinated (0 or 1 does)
~51% are #BREAKTHROUGHS.
Of those #Breakthrough cases,
535 cases w/ 2 #vaccine doses
140 cases w/ 3 doses (i.e., booster)
What do we know about the B.1.1.529 variant of SARS-CoV-2 with a very large number of mutations
An updated thread on emerging evidence.
An updated thread on emerging evidence.
B.1.1.529 is a newly designated variant of SARS-CoV-2 github.com/cov-lineages/p…
This would not have been possible without the exemplary work of researchers in Africa who have sequenced and deposited the genomes in public domain which forms the basis of this variant designation.
This would not have been possible without the exemplary work of researchers in Africa who have sequenced and deposited the genomes in public domain which forms the basis of this variant designation.
The lineage (variant) is characterized by 32 conserved spike mutations A67V Δ69-70 T95I G142D/Δ143-145, Δ211/L212I ins214EPE G339D S371L S373P S375F K417N N440K G446S S477N T478K E484A Q493K G496S Q498R N501Y Y505H T547K D614G H655Y N679K P681H N764K D796Y N856K Q954H N969K L981F
@sajidjavid uses the word HAVE not DO ..... the devil is in the detail and he knows that the vaccine no longer works for the #DeltaVariant or any of its offspring !
1. The novel coronavirus, or SARS-CoV-2, has a complex structure, and different parts of the virus trigger the immune system to produce different antibodies to neutralise the virus.
2. If an unvaccinated person catches the virus, they will produce antibodies that prevent the virus from entering human cells. They may also generate antibodies that do not have much impact.
I'm excited to share with you our recent @biorxivpreprint where we demonstrate that @vaxart mucosal Ad5 #SARSCoV2 vaccines not only protected against disease but also reduced transmission after post-#vaccination #SARSCoV2 infection in a hamster model. biorxiv.org/content/10.110… A🧵/
If you follow me, you are well aware of my obsession w/ #mucosalimmunity.😂Protection generated at mucosal surfaces is at the crux of one of the biggest questions we need to answer during this unique phase of the #pandemic - How do we decrease #SARSCoV2 #transmission to others.
Considering most of the world is unimmunized (including most kids <12), the possibility that a vaccinated individual with a post-vaccination infection (aka #breakthrough) can spread #SARSCoV2 is a public health risk. We need #transmissionblocking strategies.
I'm just getting past a #BREAKTHROUGH bout with #COVID19.
I was vaccinated with the J&J vaccine on 4/10/2021.
I have no idea how I got it. I just started with three symptoms
I was vaccinated with the J&J vaccine on 4/10/2021.
I have no idea how I got it. I just started with three symptoms
on Saturday, 9/4/2021, I started smelling a 'residual' odor and felt slightly nauseous, like an early flu. I stopped eating and limited my drinking to water and gatorade.
this persisted for three days, until I told a wonderful friend, who started bringing me care packages, including the only solid food that I ate for two weeks - bananas. It seemed to be the only food without an aftertaste.
Daily Bookmarks to GAVNet 09/15/2021 greeneracresvaluenetwork.wordpress.com/2021/09/15/dai…
The Atoms of Preparedness
appliedcomplexity.substack.com/p/the-atoms-of…
#ScenarioPlanning #FutureTrends #preparedness #ComplexityScience
appliedcomplexity.substack.com/p/the-atoms-of…
#ScenarioPlanning #FutureTrends #preparedness #ComplexityScience
The tangled history of mRNA vaccines
nature.com/articles/d4158…
#mRNAVaccines #ResearchHistory #breakthrough #COVID19 #PandemicResponse
nature.com/articles/d4158…
#mRNAVaccines #ResearchHistory #breakthrough #COVID19 #PandemicResponse
Here' my "n=1 / anecdote / was clearly bored" symptom diary of my #breakthrough #COVID19 case. And a short thread on things I found interesting about the disease process. (1/n)
My symptoms were not unique or special. They generally tracked with other reports on breakthrough delta infection in Isreal, Singapore, and US. Link to CDC report on Provincetown outbreak below as an example. (2/n)
cdc.gov/mmwr/volumes/7…
cdc.gov/mmwr/volumes/7…
Let's talk about rhinorrhea, or runny nose - worst I've ever had. Was almost comical how many paper tissues I burned through. Makes sense, as nasal epithelial cells and are prime targets of SARS-CoV-2--> damage+inflammation. (3/n)
jci.org/articles/view/…
jci.org/articles/view/…
Ergänzend zum gestrigen #OktoberImAugust Thread heute noch ein paar weitere Einblicke in #Hospitalisierungen #Kinderdurchseuchung
TLR: #KeineEntkopplung:
Steigt Inzidenz, steigt #Belastung der Krankenhäuser - und der niedergelassenen sowieso.
Ausführlicher im Thread:➡️
1/x
TLR: #KeineEntkopplung:
Steigt Inzidenz, steigt #Belastung der Krankenhäuser - und der niedergelassenen sowieso.
Ausführlicher im Thread:➡️
1/x
2/
Betrachtet man die #Hospitalisierungsinzidenz-en für alle Altersgruppen über den Gesamtzeitraum, sieht erstmal alles #Tutti aus, weniger als KW44/20 bis 23/21.
Aber zu den Werten gehörten auch 90.000 Tote, das wollen wir ja auch nicht wiederholen.
Wie ist der Trend?
➡️
Betrachtet man die #Hospitalisierungsinzidenz-en für alle Altersgruppen über den Gesamtzeitraum, sieht erstmal alles #Tutti aus, weniger als KW44/20 bis 23/21.
Aber zu den Werten gehörten auch 90.000 Tote, das wollen wir ja auch nicht wiederholen.
Wie ist der Trend?
➡️
3/
Betrachtet man letzte 2 Monate, steigt nicht nur #Hospitalisierung bei #Kinderdurchseuchung, sondern auch bei 80+ sehr deutlich,
ebenfalls 60-79Jahre steigend, ähnliche Höhe wie #Hospitalisierungsinzidenz der 0-4Jährigen.
War das zu erwarten?➡️
Betrachtet man letzte 2 Monate, steigt nicht nur #Hospitalisierung bei #Kinderdurchseuchung, sondern auch bei 80+ sehr deutlich,
ebenfalls 60-79Jahre steigend, ähnliche Höhe wie #Hospitalisierungsinzidenz der 0-4Jährigen.
War das zu erwarten?➡️
#GetVaccinated vs. #COVID. Vaccines stave off hospitalization, death and even worse for some people, sexual performance. Let's discuss some of the math, pros and cons, and adverse effects and that sexual performance thing. THREAD: texastribune.org/2021/07/21/cor…
2/ Most who are dying or are being hospitalized are unvaccinated. The vaccines don't give 100% immunity, but they are free, easy, painless and provide good protection. They also greatly decrease the impact of COVID if you do get it.
apnews.com/article/corona…
apnews.com/article/corona…
3/ COVID vaccines don't magnetize you and are too small to insert a tracker. Regardless, the government can already track you through your phone, computer, email, credit cards, social media, etc., etc., etc. Fully vaccinated folks are now <1% of deaths. cnet.com/health/99-of-c…
#Breakthrough #infections #CDC #Walensky
(1/n) Under Walensky the CDC stopped tracking breakthrough infections back in May if they didn't require hospitalization. It helps keep down the numbers since hospitalization is rare among the fully vaccinated.
newsweek.com/why-did-cdc-st…
(1/n) Under Walensky the CDC stopped tracking breakthrough infections back in May if they didn't require hospitalization. It helps keep down the numbers since hospitalization is rare among the fully vaccinated.
newsweek.com/why-did-cdc-st…
(2/n) Keeping numbers low this way may have seemed reasonable at the time since they wanted people to get vaccinated and since infection with Alphav rarely resulted in infectious fully vaccinated individuals.
cnn.com/2021/08/05/hea…
cnn.com/2021/08/05/hea…
(3/n) However, this means that when the effectiveness of vaccines is measured in terms of the prevention of severe COVID it misses a great deal of infections among the fully vaccinated, as was belatedly learned by a John Hopkins epidemiologist...
baltimoresun.com/opinion/op-ed/…
baltimoresun.com/opinion/op-ed/…
#Moderna says its vaccine shows durable 93% efficacy through 6 months.
Final analysis (median follow-up 5.3 mo):
-Against COVID19: 93.2%
-Against severe COVID19: 98.2%
-Against death: 100%
(Note: All data prior delta) 1/
Final analysis (median follow-up 5.3 mo):
-Against COVID19: 93.2%
-Against severe COVID19: 98.2%
-Against death: 100%
(Note: All data prior delta) 1/
Further break down of #Moderna efficacy by 2-month segments post 2nd dose; at month 4+, efficacy is 92.4%
#Pfizer vax (by months 4-6) efficacy is 84% - though against severe disease maintains 97%. 2/
#Pfizer vax (by months 4-6) efficacy is 84% - though against severe disease maintains 97%. 2/
Yet it expects antibody levels will start to wane, and with #delta there will be an increase in #breakthrough infections in fully vaccinated; it sees need for #boosters 3/
The Disregard of #InformedConsent and Echoes of Nuremberg Part 2 - “The Great Pivot” - Jab hesitancy is informed, literate, and sophisticated, but government agencies, officials, and politicos pushed false narratives - by @TraderStef 4 #CrushTheStreet #ADE crushthestreet.com/articles/break…
I am moving "The Great Pivot & Echoes of Nuremberg Part 2" #InformedConsent2 (the thread from @RWMaloneMD's gracious RT ) to my acct original here. Replies were breaking apart/not keeping continuity under his RT. Chronology is now intact. Apology for move.
Here is a link to PART 1 of “The Disregard of Informed Consent & Echoes of Nuremberg” (is hash tagged as #InformedConsent). That thread's continuity is intact and extensive, from March 31 to Aug 3.
SPEAKING THE UNSPEAKABLE
I despair of being free of the coronavirus.
Not because we lack the tech, but because we lack the will.
Things which make no sense to me, things which seem cruel or outright monstrous and I am forced to ask: why?
Welcome to #SpeakingTheUnspeakable.
I despair of being free of the coronavirus.
Not because we lack the tech, but because we lack the will.
Things which make no sense to me, things which seem cruel or outright monstrous and I am forced to ask: why?
Welcome to #SpeakingTheUnspeakable.
• The #pandemic hasn't ended.
• #Governments, due to corporate pressures, are forcing people back to work.
• You may be #vaccinated, but you are NOT safe.
• The #coronavirus will last longer, cost more & kill millions more people worldwide.
• #Governments, due to corporate pressures, are forcing people back to work.
• You may be #vaccinated, but you are NOT safe.
• The #coronavirus will last longer, cost more & kill millions more people worldwide.
• @FoxNews's #disinformation efforts have proven to be more effective at misleading people than our government has been at leading them.
• Unchecked #misinformation and #socialmedia have been integral to developing the failed rhetoric on the vaccination effort.
• Unchecked #misinformation and #socialmedia have been integral to developing the failed rhetoric on the vaccination effort.
1/ Transplant patients have significantly reduced antibody responses to #COVID vaccination. But does that matter? This report shows that it does. SOT recipients have a 82-fold higher risk of #breakthrough infection compared to immunocompetent hosts.
journals.lww.com/transplantjour…
journals.lww.com/transplantjour…
2/ Even more important, serious consequences of #breakthrough infection are even more common in SOT receipts. They have a 485-fold higher risk of breakthrough infections that lead to hospitalization or death.
3/ Reporting the results as cases per million vaccinated puts this into perspective. For example, the CDC reported that a little more than 1 in 1 million normal hosts (immunocompetent ppl) will die from COVID following vaccination. For transom at recipients, that number is 664.
#Thread
Apollo Hospital's Pan India study of #Breakthrough infections over 31,621 Healthcare workers showed that only 4.28% (1,335) subjects got infected post-vaccination. @RajeevJayadevan
1/5
#vaccination
Apollo Hospital's Pan India study of #Breakthrough infections over 31,621 Healthcare workers showed that only 4.28% (1,335) subjects got infected post-vaccination. @RajeevJayadevan
1/5
#vaccination
The finding also showed only 90 cases (0.28%) required hospitalization, while merely 3 (0.009%) suffered severe complications and progressed to ICU admission. @DrLahariya @satya_yadav
2/5
#VaccinesWork
2/5
#VaccinesWork
The most important finding of the study was that there were no deaths in case of COVID infection after vaccination. Many other studies of breakthrough infections have also noted no deaths post-vaccination. @docanoopmisra
3/5
#VaccinesSaveLives
3/5
#VaccinesSaveLives
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
Entscheidung, die wir für unsere Kinder treffen müssen ist nicht #impfung oder keine Impfung, sondern Immunität durch Impfung oder durch Infektion mit #SARSCoV2 und allen damit möglichen Folgen wie #COVID19 (sehr selten) und #LongCovid (eher nicht ganz so selten).
THREAD
1/10
THREAD
1/10
#STIKO agiert offensichtlich immer noch völlig losgelöst von Herausforderungen dieser #Pandemie. Als ob wir unendlich Zeit hätten auf alle Daten zu warten und dann zu entscheiden. Schön wär's, aber manchmal ist "Nicht handeln das Schlimmste" (Gruß an @rezomusik)
2/
2/
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
The WHO declared a coronavirus variant first identified in India, B.1.617, as a “variant of concern,” the agency’s fourth such designation wsj.com/articles/coron…
One can understand the gravity of this announcement: The Indian variant, #B1717 is now clubbed with UK #B117, SA #B1351 & Brazil’s #P1
I think this data is saying "Take B.1.617 very seriously and surge test, contact trace, support isolation of cases & contacts, ring vaccinate - NOW" @chrischirp Look, experts from UK are sounding alert on a variant originated from here! And what was our response?
