Discover and read the best of Twitter Threads about #BookedAndBusy

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When I took on leadership of the #CHIP clinic @DanaFarber @DanaFarberNews, I was #bookedandbusy lots of #CHIP & #CCUS had been diagnosed since we rolled out our clinical NGS panel in 2014/15. But the uncertainty (the “indeterminate potential”) was disquieting.
Imagine someone hands you a grenade & says: don’t worry most don't explode. But some do. But most explosions don't kill you. But some do. We don’t know which grenade you have. Oh, and you must hold it forever

That's a hematologists diagnosing CHIP/CCUS, precursors to #MDS & #AML
In truth, we're not totally compass-less. @jaiswalmdphd noted the association between high RDW & progression to myeloid neoplasm (MN) in early work.

Luca Malcovati & others noted risk was genotype specific: splicing factor mutations are higher risk than DNMT3A mutations
Read 22 tweets
Dear @VP Pence,
I wanted to give you a few tips as you begin to prepare for your debate w/ @SenKamalaHarris. It’s on the nuances of arguing w/ a black woman.
1)If she says, “First of all”, know that you’ve already lost. she is about to read you for all of your life. Take cover
2) If she lets you continue to talk and tilts her head to the side with a little smirk... you are about to get BODIED with facts. She peeped your lie and is allowing you to dig that hole that you will want to crawl in when she’s done. If you see it, stop mid sentence. Give in.
3) If you see an eyebrow raised it’s because you just said something absolutely disrespectful. Shows you don’t have home training and the brow is serving as a warning bell for you to shape up and tighten up.
Read 5 tweets

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