Discover and read the best of Twitter Threads about #Borrelia
Most recents (18)
NEW RESEARCH: Herbal and enzyme formula effective at reducing #Biofilms. Biofilms are a polysaccharide matrix secreted by microbes to create a protective community. Think of a biofilm like Jello surrounding a raspberry in a dessert (continued in comments). #Lymedisease #Lyme
1/5 Biofilms can make bacteria up to a thousand times more resistant to antibiotics. #Candida and #Borrelia (the bacteria that cause Lyme disease) commonly produce biofilms.
2/5 This newly published research study examined the effect of an herbal and enzyme formula containing NAC, cranberry, berberine, rosemary, peppermint, and enzymes on biofilm mass on five pathogens.
🧵A collection of my favorite research papers, articles and useful documents on #LongCovid #MECFS and other similar infection associated diseases.
1/n
archive.ph/3ywxg
1/n
archive.ph/3ywxg
2/ Large compilation of papers on SARS-CoV-2 reactivation/recurrence and persistence.
3/ #MECFS roadmap made by Hip.
"It is possible to make major improvements in health level with the right ME/CFS treatments."
mecfsroadmap.altervista.org
Mini version:
mecfsroadmap.altervista.org/mini-roadmap.h…
"It is possible to make major improvements in health level with the right ME/CFS treatments."
mecfsroadmap.altervista.org
Mini version:
mecfsroadmap.altervista.org/mini-roadmap.h…
Joseph Burrascano, MD - Diagnostic Tools
#Lyme Clinical Presentation: nonspecific, viral-like symptoms that persist, & new ones appear. Then symptoms more focused on musculoskeletal, peripheral and central nervous systems, heart and skin. Muti-systemic & migratory. #ILADS2022
#Lyme Clinical Presentation: nonspecific, viral-like symptoms that persist, & new ones appear. Then symptoms more focused on musculoskeletal, peripheral and central nervous systems, heart and skin. Muti-systemic & migratory. #ILADS2022
2/Burrascano: Sorting out the co-infections #NotJustLyme #Bartonella #Babesia #Ehrlichia #Anaplasma #Mycoplasma #ILADS2022
3/Burrascano: Types of tests
SEROLOGIES are indirect, B-cell based tests:
B-cells create antibodies and serologies measure these antibodies #ILADS2022
SEROLOGIES are indirect, B-cell based tests:
B-cells create antibodies and serologies measure these antibodies #ILADS2022
Robert Bransfield, MD: Thousands of peer-reviewed journal articles demonstrate the causal association between infections and #mentalillness 400+ peer reviewed scientific articles demonstrate the causal association between tick-borne disease and mental illness. #ILADS2022 #Lyme
2/Bransfield: Up to 40% of patients w/ #Lyme develop peripheral or central nervous system involvement. Psychiatric reactions include: #paranoia #dementia #schizophrenia #bipolar #panicattacks #depression #anorexianervosa, and #ODC #ILADS2022
3/Bransfield: Lyme is over represented in psychiatric patients. #ILADS2022
"The Lyme disease bacteria—Borrelia burgdorferi—is definitely one of the smartest bacteria on the planet. The spirochete is a spiral shaped organism. And because of its spiral shape, and the fact that it has many tales, called flagella...
...this organism knows how to move through the tissues. It can disseminate throughout the body and into your central nervous system.
So we know what syphilis can do to the body—which is a spirochetal infection. And the problem is, Lyme is the great imitator, just like syphilis was.
The most common misdiagnoses that I see in my practice are people who have been diagnosed with chronic fatigue syndrome...
The most common misdiagnoses that I see in my practice are people who have been diagnosed with chronic fatigue syndrome...
#idboardreview 25 M 1 wk post vacation in california mountain cabin: febrile x3d then felt better for 7d and now having fevers again, chills, myalgia, dyspnea progressed to ARDS. wbc3k, Hb11, plt20k, peripheral smear shown. Dx? vector? reservior? #idmeded #IDTwitter
#idboardreview 30 M from western 🇺🇸 visited Middle East where symptoms of recurrent fevers >102F, headaches, myalgia, chills started
3 wks ago. Peripheral blood smear shown. Dx? #medEd #idmedEd #IDtwitter
3 wks ago. Peripheral blood smear shown. Dx? #medEd #idmedEd #IDtwitter
Rick borne relapsing fever #TBRF #Borrelia persica inspired by jcm.asm.org/content/58/6/e… @ASMicrobiology pic ref P&P Mandell
median incubation period of 7d (range 2-18d): fever x 3d (range 2-7d), alternating w/ afebrile periods lasting about 7d range 4-14d)
If untreated #TBRF can have up to 30 relapses of febrile illness (most pts w/2 relapses)
whereas louse-borne illness is usually has only 1 relapse
If untreated #TBRF can have up to 30 relapses of febrile illness (most pts w/2 relapses)
whereas louse-borne illness is usually has only 1 relapse
This interesting study found that skeletal #muscle cells of #ME/CFS patients showed a decrease in oxidative phosphorylation (a metabolic pathway used by #mitochondria to generate #energy). In simple terms, that caused the cells to have a dysregulated #metabolism.
2/ Not mentioned in the paper, but important to consider, is that most well-studied #viral + bacterial #pathogens “hijack” the metabolism of the cells they infect in a manner that can result in decreased oxidative phosphorylation (or similar changes in cell energy pathways).
3/ In simples terms, these #pathogens “hijack” cell metabolism to “pull” substrates out of the human mitochondrial energy pathways...and use the substrates (lipids, fatty acids, amino acids) for their own #nutritional and replication purposes!
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker Walker hi - I very much disagree that #Borrelia or #EBV are typically ” long gone” in infected patients who develop chronic symptoms.
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker 2/ There is a large body of literature showing that even if such #organisms cannot be found in blood, they can persist in certain tissues or the central #nervous system where they are very hard to identify clinically
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker 3/ This is particularly obvious w/ EBV which is a #herpesvirus. Herpesviruses almost never “clear” after #infection, and symptom resolution is due to the immune system’s ability to contain the #virus in a non-replicating state
Here it is!
#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157
It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology
#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157
It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology
#Inktober2020 day 2 in my #PathogenPortraits series. 'The Clap' (Neisseria gonorrhoeae) b/c who doesn't 💚 green purulent discharge?
It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…
#sciart #microbiology
It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…
#sciart #microbiology
#Inktober2020 day 3 in my #PathogenPortraits series. The very 💛golden💛 #MRSA.
Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.
More info at mrsaactionuk.net/MRSA.html #sciart #microbiology
Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.
More info at mrsaactionuk.net/MRSA.html #sciart #microbiology
@adamswendya @errinbaccari @danaparish Wow thanks for sharing b/c I had not seen the study! What’s awesome is they didn’t just show that #Borrelia cld infect choroid plexus epithelial cells...they also demonstrated the substantial gene expression changes driven by the #pathogen in infected cells
@adamswendya @errinbaccari @danaparish 2/ That Borrelia downregulated genes related to cell to cell junctions (including tight and adherens junctions)...is a a direct mechanism of action finding on how the organism can cause the BBB to become more permeable
@adamswendya @errinbaccari @danaparish 3/ Can you imagine the “double hit” of already harboring Borrelia in the choroid plexus, and then getting #COVID-19 that can infect the same area? Or some version of that pattern? Each pathogen cld support the potential CNS entry of the other
Cool paper detailing what body sites, cell types, symptoms #COVID-19 has been connected to thus far 👉 But one thing: everyone knows that most persistent #viral (and #bacterial) pathogens are capable of #infecting/driving an equally extensive # of #symptoms, right?
2/ For example, in this interview, Dharam Ablashi (who co-discovered the #virus HHV6) explains how HHV6 has been shown capable of contributing to #cancers, type 1 #diabetes, Hashimoto’s, #MS, HPA-axis dysregulation, ME/CFS, Alzheimer’s, neuroinflammation..microbeminded.com/2020/06/28/int…
3/ ..and that the HHV6 can survive in
#microglia, astrocytes, macrophage, neurons/nerves, #pancreatic islet cells, the lung, gut epithelial cells, the #liver etc etc etc!
#microglia, astrocytes, macrophage, neurons/nerves, #pancreatic islet cells, the lung, gut epithelial cells, the #liver etc etc etc!
Cool new study which found that a range of #pathogens (some capable of long-term persistence in tissue + #blood) upregulate expression of the cell surface protein CD47 in the host cells they infect as an #immune evasion strategy
2/ I fact, upregulation of CD47 is a very smart survival strategy by such pathogens, b/c it interferes w/ the host innate immune response that is normally supposed to identify, target and kill them!
This study found that Epstein Barr #Virus (EBV) IgM antibody seropositive #COVID-19 patients had a 3.09-fold increased risk of fever compared to EBV seronegative patients. Inflammatory markers like C-reactive protein were also higher in the EBV+ patients: researchsquare.com/article/rs-215…
2/ The study is a small, but good example of the how already-acquired persistent #pathogens can influence how a person responds to a new #infection: the existing pathogen(s) might cause additional symptoms or influence how the #immune system can respond to the new infection
3/ For example this study found that persistent Cytomegalovirus (CMV) infection caused ~10% of all T cells in CMV+ individuals to be directed against that virus. Could harboring CMV then change how the adaptive immune system responds to COVID-19?: ncbi.nlm.nih.gov/pmc/articles/P…
@DrShawnL Hey - b/c they have shown that amyloid beta appears to actually be an antimicrobial peptide that - at least in the lab/mice - forms in response to a range of bacterial, viral + fungal pathogens capable of persisting in the CNS, including the herpesviruses: ncbi.nlm.nih.gov/pmc/articles/P…
@DrShawnL 2/ Related studies by team’s like @G_Tetz support their findings. Here Tetz found that, in the lab, Tau formation may be additionally promoted by DNA from bacterial pathogens like Borrelia: nature.com/articles/s4159…
@DrShawnL @G_Tetz 3/ Meanwhile herpesviruses have been identified in human Alzheimer’s autopsied brains + shown capable of driving neuroinflammation (cell.com/neuron/pdfExte…) So has oral pathogen p. gingivalis and the toxic gingipains proteins it produces (advances.sciencemag.org/content/5/1/ea…)
1/1 Team uses range of technologies to study brain, heart, kidney + liver tissue of a patient w/ #Lyme disease who received many antibiotics over 16 yrs 👉 Identify significant pathological changes, including borrelial spirochetal clusters in all organs: mdpi.com/antibiotics/an…
2/2 The aggregates contained a well-established #biofilm marker, alginate, on their surfaces, suggesting they are true biofilm 👉 IHC analysis also showed significant numbers of infiltrating CD3+ T lymphocytes present next to #Borrelia burgdorferi biofilms
3/3 Team concludes 👉 “...we provide several lines of evidence that suggest that B. burgdorferi can persist in the human body, not only in the spirochetal but also in the #antibiotic-resistant biofilm form, even after long-term antibiotic treatment”
This same pattern applies to much of the #microbiome community 👉 It’s hard to challenge the “consensus” that the human brain, CSF + womb are “sterile”...when the #NIH barely funds such topics, and novel results from privately funded studies are repeatedly blocked in peer-review
Example 👉 Robert Moir’s novel finding that #amyloid beta functions a potent antimicrobial peptide strongly suggests that communites of #pathogens persist in the #Alzheimer’s brain☝️But read how often his papers have been blocked in peer review: statnews.com/2018/10/29/alz…
Quote from the article 👉 “The first journal [Moir] submitted his results to, #Science, “looked like they would take it,”....But after what editors told him was “a consultation with our #Alzheimer’s disease experts,” it rejected the paper. So did three other journals.”
Why is the future of chronic #inflammatory disease #polymicrobial (organisms interacting)? 👉 This paper describes how even in #Lyme Neuroborreliosis, different strains of Borrelia often persist in a #biofilm, or community-based form: frontiersin.org/articles/10.33…
The ability of Borrelia to form into #biofilm communities may 👉 “explain the low rate of Borrelia detection in the #blood of infected #patients as well as the ability of the #spirochetes to evade the host immune system and resist the antibiotic therapy”: frontiersin.org/articles/10.33…
Here are two images 👉 On the left, a #Borrelia biofilm as seen under a #microscope☝️On the right, a diagram showing how chronic, persister forms of Borrelia can survive inside a #biofilm: where they are better protected from the host immune response: frontiersin.org/articles/10.33…
