Discover and read the best of Twitter Threads about #BrainMapping

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Different cell types in the brain have their own connectivity rules and patterns. In a recently published study, our #neuroscience researchers took a deep dive into the connectomics of an important but enigmatic cell type, the chandelier cell. 🧵1

📄 elifesciences.org/articles/73783
🔬 💻 Using large-scale #electronmicroscopy with automated segmentation, we mapped the complete axo-axonic input onto pyramidal neurons (1,929 synapses in total, 1,127 from chandelier cells) in a volume of layer 2/3 of mouse visual cortex. #ImagingTheFuture #BrainMapping🧵2
By completely reconstructing the presynaptic chandelier cells, we found a novel principle of connectivity, where a group of interneurons are essentially interchangeable, but their postsynaptic targets individually regulate the amount of input they receive from the population. 🧵3
Read 7 tweets
In a new study out in @nature, our researchers make a big step forward in our quest to map the brain. Study findings lay the groundwork to better understand brain disorders & diseases such as #Alzheimers and #schizophrenia.

alleninstitute.org/what-we-do/bra…
This new study describes a high-resolution expansion of our #openscience Allen Mouse Brain Connectivity Atlas-- the most detailed map of connections in a mammalian brain to date. Access via: connectivity.brain-map.org
Using a computational approach, our researchers found that different sections of the cortex and thalamus can be mapped into a hierarchy, much like a company’s org chart – although not all connections followed this hierarchical structure. #brainmapping
Read 5 tweets

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