Discover and read the best of Twitter Threads about #CANVAS

Most recents (24)

1) Welcome to our #accredited #tweetorial on clinical trial results and emerging data for treatment of Diabetes and CKD #DM in #CKD. I am Brian Rifkin MD, @brian_rifkin, from the Hattiesburg Clinic. #Nephtwitter #Medtwitter #FOAMed
2) This #accredited #tweetorial series on #kidneydisease #CKD is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance. It is not intended for US- or UK-based HCPs. Accreditation statement & faculty disclosures at ckd-ce.com/disclosures/.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Prior programs in this series, still eligible for CE/#CME, can be accessed at ckd-ce.com. FOLLOW US to learn from expert faculty!
Read 41 tweets
1) Welcome to our new #accredited #tweetorial which is Part 2 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this 🧵!
2a) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. Our expert author is Dr. Clara GarcĂ­a Carro (@ClaraGCarro) from San Carlos Clinical Hospital (Madrid, Spain).
2b) Be sure to check out the first half of this #ERA22 recap from my colleague @shbermejo, and get MORE 🆓CE/#CME at ckd-ce.com/dkd12_ERA22a/. Join me in following @ckd_ce for the BEST in #cardiorenal education delivered entirely by #tweetorial!
Read 48 tweets
New in @JACCJournals w @JJheart_doc on intersection of biomarkers & #SGLT2i in #T2D.

Canagliflozin in #CANVAS
⤵️hs-cTnT & sST2 out to 6yrs
⤵️HF & kidney outcomes irrespective of baseline biomarkers
⤵️MACE particularly in those w multiple abnormal markers

jacc.org/doi/10.1016/j.…
In >3Kđź‘Ąin #CANVAS, canagliflozin (versus PBO) reduced #hscTnT (marker of cardiac injury) & #sST2 (marker of vascular congestion, inflammation & fibrosis) out to 6yrs

Importantly, rather than reducing biomarkers below baseline, #SGLT2i appear to delay longitudinal rise after 1yr
Canagliflozin consistently ↓ a broad set of HF & kidney disease outcomes, irrespective of biomarker profiles.

Interestingly, elevated #hscTnT & #sST2 (& a multi-marker panel) each identified greater *relative* benefits for MACE...including among those without established ASCVD
Read 5 tweets
1/ Antiepileptic drugs: a constantly evolving frontier- like many other fields in #Neurology. It’s hard to know about every single medication in-depth. Here, I attempted to make AEDs simple, easy to understand and a handy layout of important facts to know about #AED #epilepsy.
2/ Let’s begin with understanding what is synapse and how it works, then only we can understand how the AEDs work. Look at the cartoon I created from references (acknowledged at the end) with help of an amazing app #Procreate. I’m a fan of @PeterMLawrence1 great art work !!
3/ Looks chaotic?Let’s break it down. You got this!
There are 2 main types of synapses.
A)Excitatory synapse-neurotransmitter is Glutamate- receptors are AMPA and NMDA
B)Inhibitory synapse-neurotransmitter is GABA-receptor is GABAa binding site on ligand gated Cl- channel
Read 24 tweets
A tweetorial.

Here's an intriguing analysis just published in Diabetes Care by the great folks at @AmDiabetesAssn and @ADA_Journals. We examined concentrations of insulin-like growth factor binding protein-7 (IGFBP7) at BL and 1Y in the CANVAS study.

care.diabetesjournals.org/content/early/…

1/
Why IGFBP7? Good question.

Though IGFBP7 "looks like" an IGF binder, it is lousy at this job. But IGFBP7 has other roles: it is a cell cycle arrest biomarker in the 'senescence associated secretory phenotype'.

When cells are exposed to IGFBP7 in excess, fibrosis follows.

2/
We previously found IGFBP7 was associated with cardiac structural and functional abnormalities and outcome in patients with heart failure, but we were interested to see how it would act in patients with #T2D, such as those in CANVAS.

Why?

3/
Read 16 tweets
Dr. Jardine on side effects of SGLT2i. Where is evidence coming from? #Kidneywk
Mostly is coming from CREDECE since it has the largest population of advanced CKD. Side effects are not different across different stages of CKD #Kidneywk
Hypoglycaemia not common, about 1%. DKA is rare (1 case per 1000 users) but real mostly seen in people who require insulin. #kidneywk
Read 13 tweets
California's May budget revise is out; one of the first signs of how states might deal with COVID-changed finances. Here is summary:
ebudget.ca.gov/FullBudgetSumm…
p. 48: "... the number of students seeking to enroll at UC, CSU, and CCC campuses is expected to grow in the coming years. CCCs, in particular, will likely see notable increases because their enrollment tends to rise when economic challenges emerge. "
This is interesting: "Collaboratively adopt the use of a common online learning management system, for example, Canvas, which is already used by over 80 percent of the UC, CSU, and CCCs." #LMS #Canvas
Read 16 tweets
Botticelli Adoration of the Christ Child Case-Mate iPhone Case zazzle.com/z/pjhjw?rf=238…
@threadreaderapp please unroll
Read 3 tweets
I interrupt the relentless assault on our Mother Earth led by the ruling classes, to bring to your attention to critical information by @Mision_Verdad regarding a new coup attempt underway in Bolivia. This relates to the #Amazon fires media saturation. #NPIC #Imperialism
@Mision_Verdad Capitalism never sleeps. Nor does imperialism.

The original article by @brunosgarzini for @Mision_Verdad:

LA HUELLA DE ESTADOS UNIDOS EN LA INCIPIENTE REVOLUCIĂ“N DE COLORES EN BOLIVIA:

misionverdad.com/columnista/rev…
@Mision_Verdad @brunosgarzini It has been translated into English by @libya360 on the Internationalist website (which everyone should subscribe to).

The U.S. Footprint in Bolivia’s Incipient Colour Revolution

libya360.wordpress.com/2019/08/30/the…
Read 41 tweets
Children on the Seashore Guernsey
Pierre-Auguste #Renoir

zazzle.com/children_on_th…
Children on the Seashore Guernsey
Pierre-Auguste #Renoir #Postcard

zazzle.com/children_on_th…
Children on the Seashore Guernsey
#Renoir #Canvas #Print

zazzle.com/children_on_th…
Read 4 tweets
Sir Launcelot in Queen's Chamber
Dante #Rossetti

zazzle.com/sir_launcelot_…

#preraphaelite #art
Sir Launcelot in the Queen's Chamber
Dante Gabriel Rossetti
Pen with black and brown #ink #drawing on paper, 1857

zazzle.com/launcelot_in_q…
Sir Launcelot in Queen's Chamber
Dante Rossetti #Canvas #Prints

zazzle.com/sir_launcelot_…
Read 4 tweets
Self-Portrait with Beret
#Rembrandt van Rijn

zazzle.com/self_portrait_…
Self-Portrait with Beret and Turned-Up Collar
#Rembrandt van Rijn #Canvas #Posters

zazzle.com/self_portrait_…
Self-Portrait with Beret
#Rembrandt van Rijn #Postcard

zazzle.com/self_portrait_…

-
Read 4 tweets
Salutation of Beatrice
Dante Gabriel #Rossetti

zazzle.com/salutation_of_…
Salutation of Beatrice
Dante Gabriel Rossetti, oil on canvas, 1880-1882

zazzle.com/salutation_of_…

#PreRaphaelite #art
Salutation of Beatrice
Dante Gabriel Rossetti, oil on #canvas, 1880-1882

zazzle.com/salutation_of_…
Read 4 tweets
#Art of William-Adolphe #Bouguereau
Forgotten master of 19th century classical academic realism

zazzle.com/artpompier?rf=…

#fineart #prints
#Art of William-Adolphe #Bouguereau

pinterest.com/argentarts/bou…

William-Adolphe Bouguereau, forgotten master of classical academic #realism of the 19th century French Salon
The Nut Gatherers (Les Noisettes)
William-Adolphe #Bouguereau
oil on #canvas, 1882

zazzle.com/nut_gatherers_…
Read 9 tweets
Still Life with Oysters Rummer Lemon Silver Bowl
Willem Claeszoon Heda

zazzle.com/still_life_wit…
Still Life with Oysters, Rummer, Lemon and Silver Bowl
Willem Claeszoon Heda, oil on canvas, 1634

zazzle.com/still_life_wit…
Still Life with Oysters, a Rummer, a Lemon and a Silver Bowl
Willem Claeszoon Heda Glossy #Poster

zazzle.com/still_life_wit…
Read 5 tweets
Study for Patriotism
Puvis de Chavannes #Canvas #Prints

zazzle.com/study_for_patr…
Study for #Patriotism
Pierre Puvis de Chavannes

zazzle.com/study_for_patr…
@threadreaderapp please unroll
Read 3 tweets

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