Discover and read the best of Twitter Threads about #CCR20
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Here’s what we did in the #PEPTICtrial, what we found, and what I think it all means. #CCR20 @jama_current
We conducted an international, randomized, open-label, cluster crossover, registry-embedded trial to compare strategies of stress ulcer prophylaxis in mechanically ventilated adults implemented at the level of the ICU jamanetwork.com/journals/jama/…
The primary outcome was in-hospital all-cause mortality up to 90 days. Secondary outcomes were clinically significant upper GI bleeding, C. difficile infection, ICU and hospital length of stay.
#65trial Primary outcome of 90-day mortality not "statistically significant", but point estimate favours perm. hypotension. Can a Bayesian re-analysis help us interpret these results? #CCR20 (1/...)
First, the best way to interpret frequentist 95% CIs that I have encountered (@EpiEllie) is to consider them to be like ring tosses - either they contain the true value or they don't: medium.com/@EpiEllie/havi… (2/...)
@EpiEllie If the study is repeated indefinitely and a 95% CI is calculated each time, 95% of these intervals will contain the true value - but for a single 95% CI we don't know whether or not this is the case (either it does contain the true value or it does not). (3/...)
