Discover and read the best of Twitter Threads about #CCS19
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1/ Why is lactate elevated in sepsis or septic shock?
@dolan_russell & I explore this common #ICU pimp question via #tweetorial.
We're taught that ↓O2 revs up anaerobic metabolism causing ↑ lactate. But wait, there's more...
#medtwitter #FOAMed #meded #FOAMcc #criticalcare
@dolan_russell & I explore this common #ICU pimp question via #tweetorial.
We're taught that ↓O2 revs up anaerobic metabolism causing ↑ lactate. But wait, there's more...
#medtwitter #FOAMed #meded #FOAMcc #criticalcare
2/ In homeostasis, lactate is continually produced and metabolized; serum concentration is at steady state.
Which of the following organs is responsible for the majority lactate consumption and metabolism?
Which of the following organs is responsible for the majority lactate consumption and metabolism?
3/ The liver is responsible for ~70% of lactate metabolism.
Patients with hepatic dysfunction can have ↑ lactate 2/2 ↓ clearance or ↑ production. Also, cirrhotics are more prone to hyperlactatemia in setting of sepsis.
Diving deeper, how does the liver metabolize lactate?
Patients with hepatic dysfunction can have ↑ lactate 2/2 ↓ clearance or ↑ production. Also, cirrhotics are more prone to hyperlactatemia in setting of sepsis.
Diving deeper, how does the liver metabolize lactate?
