Discover and read the best of Twitter Threads about #CIM

Most recents (3)

Not mutually exclusive, but most people said they'd prefer seeing rather than joining a discussion to analyze THAT erythritol paper, and I have some airport hours ahead...

Here go🧵.

In case you've been living under a rock, this is the paper:

nature.com/articles/s4159… Image
Relevant disclosures for interpreting my interpretation?

I'll speak more as a clinician clinician who sees many ⬆️CVDrisk patients following a low-carb diet than as a healthy adult who follows a low-carb diet and occasionally consumes erythritol.
Things I liked about the paper = ✅️.

Things I didn't like (and matter) = ⚠️

Things I didn't like (and are nitpicking) = 🧐.

🩸[] = blood concentration.

CVD = CardioVascular Disease.

MACE = Major Adverse Cardiovascular Events.

Why we "liked" erythritol in the first place?
Read 32 tweets
1/18) 🚨NEW PAPER in @AJCN provides evidence supporting #CIM of #obesity

👉 Glycemic Load >>> Calorie Counting for weight loss

👉 Biomarkers of Low carb diet predict weight

👉Insulin hyper-secreters especially benefit fromlow-carb

Video 👉👉
🧵... Image
2/18) First, and foremost, a big congrats to @AdrianSotoMota and @davidludwigmd for an excellent work!

& of course, for those who have the time, I highly recommend reading the full paper, here: doi.org/10.1016/j.ajcn…

But for those who prefer video or TW thread... HERE WE GO...
3/18) What the researchers did in this paper is perform a secondary analysis of pre-existing data from a 12-month RCT: the DIETFITS trial in which 609 adults aged 18-50 without diabetes were randomized to either a 12 m Low-carb diet (LCD) or low-fa diet (LFD).
Read 18 tweets
⚠️NEW PAPER⚠️
@AJCNutrition with: Mark Pereria, Cara Ebbeling, @LuciaAronica & @davidludwigmd

doi.org/10.1016/j.ajcn…

With many of my favorite things:
1) Open Science.
2)Critical analysis of high quality research.
3) Causal inference.
4) #CiCo vs #CIM
5) 1600 lines of R code.
This is a post-hoc analysis of the DIETFITS, a high-quality RCT from @StanfordMed lead by @GardnerPhD (who kindly reviewed an earlier version of our manuscript) which compared carbohydrate vs fat restriction to achieve weight-loss during one year.

jamanetwork.com/journals/jama/…
This trial found non-significant weight-loss differences between both diets.

Additionally, no interaction was observed with genotype nor hyperinsulinemia.
Read 24 tweets

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