Discover and read the best of Twitter Threads about #CNI

Most recents (9)

(132) El senador Cotton, estadounidense, niega que el #coronavirus se haya originado en el mercado de Wuhan, como se seƱalĆ³ en un principio. ĀæPuede haberse suministrado a alimentos en el mercado que despuĆ©s hayan sido consumidos?

(133) Aquƭ tenƩis un enlace a un estudio del 30 de enero sobre los primeros casos documentados de #coronavirus #COVID19 #covid_19

thelancet.com/journals/lanceā€¦
(134) Mientras tanto, tambiĆ©n en #China, hubo en febrero un rebrote del virus #H5N1 (gripe aviar) que matĆ³ a mĆ”s de la mitad de las gallinas de una granja con 8.000 especĆ­menes.

Read 69 tweets
HILO.ā¤µ

"Atentados del 11 de marzo de 2004"

Ā«El origen de los servicios secretos hispano-franco-marroquĆ­es del 11-M.Ā»

#SocialismoRadicalEspaƱol
#DinastĆ­aAlauĆ­
#PSOE
#GranOrienteEspaƱol
#GranLogiaNacionalDeFrancia
#OTAN
#CNI

@PeonesNegros
@PeonesNegros ƍndice

I. Gran Oriente EspaƱol en Marruecos (1905)

II. IntroducciĆ³n de la monarquĆ­a marroquĆ­ en la francmasonerĆ­a (1920-1927)

III. FundaciĆ³n de la Gran Logia de Marruecos por masones espaƱoles residentes en el norte de Ɓfrica (1923)
@PeonesNegros IV. Masones y militares espaƱoles en el Norte de Ɓfrica (1923-1936)

V. Gran Oriente EspaƱol: Distrito de Marruecos durante la II RepĆŗblica EspaƱola (1931-1936)

VI. Logias del Gran Oriente EspaƱol durente la Guerra Civil EspaƱola (1936-1939)
Read 56 tweets
1/ Continuing the #immunosuppression #tweetorial series...@MedTweetorials

Today's player: #mTORi, mammalian/mechanistic target of rapamcyin inhibitors

Rapamcyin was @US_FDA approved for #kidneytransplant in 2003.

It was isolated from a soil sample from which island in 1975?
2/ Meet mTOR, a phosphatidylinositol 3-kinase (PI3)-related kinase (adds a phos). mTOR adds a phosphoryl group to serine/threonine residues.

It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
3/ mTOR inhibition blocks "Signal 3" of #TCell activation - reducing cytokine dependent cell proliferation and activation.

Take a look at all 3 signals below šŸ‘‡šŸ½

nejm.org/doi/full/10.10ā€¦
Read 11 tweets
Ministry of Truth
@JosepBorrellF asks #Spain's Superior Court of Justice to close #Catalan delegations in London, Geneva & Berlin for "damaging Spain's image" based on documents intercepted by his toytown spy network and social media posts.
#BorrellGate
1
catalannews.com/politics/item/ā€¦
London

The delegation is accused of ''retweeting messages in favour of Gibraltar" and criticising Borrell's comment on us history: "they only had to kill a handful of Indians".

In this case, surely it was Borrell was "harming #Spain's image"?
#BorrellGate
2
London

Borrell's toytown diplomats found it "damaging to #Spain's image" that "there were barely 20 people" at an event with Parliament VP, @josepcosta: an Estelada on a table "looked like a coffin" and "people mocked it on social media"

#BorrellGate
3
ccma.cat/324/lespionatgā€¦
Read 11 tweets
No-show of #Spanish police and intelligence officials - Trapote, Gonzalo, PĆ©rez de los Cobos - before commission investigating terror attacks #Catalonia, Aug '17. Disrespect of #Catalan institutions and still no news of what they knew.
#ThisIsTheRealSpain
elmon.cat/politica/el-cnā€¦
Absentees:

Ex-chief of CNP Cat, SebastiƔn Trapote
Dir. CNI, FƩlix Sanz RoldƔn
Ex-chief of Civil Guard Cat, Ɓngel Gonzalo
Interior Ministry rep. to Security Commission Cat, Diego PĆ©rez de los Cobos
Dir. of CITCO, JosƩ Luis Olivera Serrano
Ex-DG of CNP, GermĆ”n LĆ³pez Iglesias

2
#Spainā€™s secret service (#CNI) admitted ā€œcontactsā€ with Abdelbaki Es Satty, the mastermind behind the terror cell but didn't clarify their frequency, duration or remuneration, only that they were within the ā€œprotocol established for convictsā€ 17/11/2017

3
elpais.com/elpais/2017/11ā€¦
Read 11 tweets
1/

A brief #tweetorial on the calcineurin inhibitors #CNI and their toxicities. Let's start with a quick poll.

Which of the following describes the main mechanism of action of #CNI?
2/

On to the mechanism of #CNI. Calcineurin inhibitors bind to the "immunophiliins" for which they are named. Cyclosporine (CsA) binds cyclophilin and tacrolimius(FK506) binds FK binding protein.

The CNI-immunophilin complex is the superhero which then inhibits calcineurin
3/
Meet calcineurin, whose superpower is a calcium-dependent PHOSPHATASE: enzyme that uses H2O to cleave phosphoric acid into a phosphate ion and an alcohol (read: removes phos)

Normally, calcineurin dephosphorylates NFAT - allowing it to freely swim into the nucleus.
Read 10 tweets
This thread contains images with passages from the Mueller Report. I will add new ones as I create them.

If you want, share them on Facebook, Instagram, print on fliers or t-shirts or postcards.

I want to show America what's in that report.
Read 25 tweets
Anyone who gives Senator My Dad Is Putin's Bitch and I'm Named After Ayn Rand airtime deserves a deep dive.
cc: @thespybrief @gametheorytoday
h/t @fire_resign
Yuri Ushakov and Dimitri K. Simes sitting in a spy dacha.
C-O-L-L-U-D-I-N-G
Read 9 tweets

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