Discover and read the best of Twitter Threads about #CNI

Most recents (6)

1/ Continuing the #immunosuppression #tweetorial series...@MedTweetorials

Today's player: #mTORi, mammalian/mechanistic target of rapamcyin inhibitors

Rapamcyin was @US_FDA approved for #kidneytransplant in 2003.

It was isolated from a soil sample from which island in 1975?
2/ Meet mTOR, a phosphatidylinositol 3-kinase (PI3)-related kinase (adds a phos). mTOR adds a phosphoryl group to serine/threonine residues.

It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
3/ mTOR inhibition blocks "Signal 3" of #TCell activation - reducing cytokine dependent cell proliferation and activation.

Take a look at all 3 signals below 👇🏽

nejm.org/doi/full/10.10…
Read 11 tweets
Ministry of Truth
@JosepBorrellF asks #Spain's Superior Court of Justice to close #Catalan delegations in London, Geneva & Berlin for "damaging Spain's image" based on documents intercepted by his toytown spy network and social media posts.
#BorrellGate
1
catalannews.com/politics/item/…
London

The delegation is accused of ''retweeting messages in favour of Gibraltar" and criticising Borrell's comment on us history: "they only had to kill a handful of Indians".

In this case, surely it was Borrell was "harming #Spain's image"?
#BorrellGate
2
London

Borrell's toytown diplomats found it "damaging to #Spain's image" that "there were barely 20 people" at an event with Parliament VP, @josepcosta: an Estelada on a table "looked like a coffin" and "people mocked it on social media"

#BorrellGate
3
ccma.cat/324/lespionatg…
Read 11 tweets
No-show of #Spanish police and intelligence officials - Trapote, Gonzalo, Pérez de los Cobos - before commission investigating terror attacks #Catalonia, Aug '17. Disrespect of #Catalan institutions and still no news of what they knew.
#ThisIsTheRealSpain
elmon.cat/politica/el-cn…
Absentees:

Ex-chief of CNP Cat, Sebastián Trapote
Dir. CNI, Félix Sanz Roldán
Ex-chief of Civil Guard Cat, Ángel Gonzalo
Interior Ministry rep. to Security Commission Cat, Diego Pérez de los Cobos
Dir. of CITCO, José Luis Olivera Serrano
Ex-DG of CNP, Germán López Iglesias

2
#Spain’s secret service (#CNI) admitted “contacts” with Abdelbaki Es Satty, the mastermind behind the terror cell but didn't clarify their frequency, duration or remuneration, only that they were within the “protocol established for convicts” 17/11/2017

3
elpais.com/elpais/2017/11…
Read 11 tweets
1/

A brief #tweetorial on the calcineurin inhibitors #CNI and their toxicities. Let's start with a quick poll.

Which of the following describes the main mechanism of action of #CNI?
2/

On to the mechanism of #CNI. Calcineurin inhibitors bind to the "immunophiliins" for which they are named. Cyclosporine (CsA) binds cyclophilin and tacrolimius(FK506) binds FK binding protein.

The CNI-immunophilin complex is the superhero which then inhibits calcineurin
3/
Meet calcineurin, whose superpower is a calcium-dependent PHOSPHATASE: enzyme that uses H2O to cleave phosphoric acid into a phosphate ion and an alcohol (read: removes phos)

Normally, calcineurin dephosphorylates NFAT - allowing it to freely swim into the nucleus.
Read 10 tweets
This thread contains images with passages from the Mueller Report. I will add new ones as I create them.

If you want, share them on Facebook, Instagram, print on fliers or t-shirts or postcards.

I want to show America what's in that report.
Read 25 tweets
Anyone who gives Senator My Dad Is Putin's Bitch and I'm Named After Ayn Rand airtime deserves a deep dive.
cc: @thespybrief @gametheorytoday
h/t @fire_resign
Yuri Ushakov and Dimitri K. Simes sitting in a spy dacha.
C-O-L-L-U-D-I-N-G
Read 9 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!