Discover and read the best of Twitter Threads about #CNS

Most recents (8)

1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
Read 10 tweets
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Read 6 tweets
Why is #asymptomatic spread important? Well today I was thinking about #polio virus. It was very #contagious, but 95% of people had no symptoms but were still infectious. About 4-5% of people had minor illness: fever, headache, nausea, vomiting, weakness. #SARSCoV2 #COVIDー19
2/ About 1-2% of people had severe muscle pain, and stiffness in the neck and back. <1% of cases resulted in #paralysis including the legs and the nerves controlling breathing and swallowing necessitating use of the iron lung #ventilators. #Polio could attack the #CNS.
3/ At its peak in 1952, more than 21,000 #Americans contracted a paralyzing form of #polio, and 3,000 died from it. Once infected, there was no treatment besides time and tending to the symptoms. Interestingly, polio mostly attacked young children under age 5.
Read 12 tweets
1/ THREAD 7: Viral Latency and a Hematogenous Route to CNS?

Is it even conceivable that #SARSCoV2 could establish latency in sensory ganglia (like trigeminal ganglia in HSV1) and reactivate to cause recurrent disease as respiratory droplets could enter the eyes, nose, and mouth?
2/ Specifically, talking about the peripheral nerves of the eyes, nose and mouth here. And thinking along the lines of why clinicians are seeing the loss of smell and altered taste in so many patients. Please remember, I am not a #virologist or an infectious disease specialist!
3/ HYPOSMIA DATA:
Both the American Academy of Otolaryngology - Head and Neck Surgery AAO-HNS and ENTUK have classified loss of smell and altered taste as significant symptoms in #COVID19. #Covid19UK

entnet.org/content/corona…

entuk.org/sites/default/…
Read 22 tweets
A prominent theory in #neuroscience hypothesizes that the #CNS generates muscle activity to simplify #motorcontrol, so that muscles with similar task actions are controlled as a single functional unit. Our results do not support this hypothesis! A thread. pnas.org/content/early/…
This theory predicts that correlations between muscles that have consistent task actions (e.g. the vastii muscles, VM, VL and VI) should be equally strong, and stronger than their correlations with task-inconsistent muscles (e.g. RF, that extends the knee and flexes the hip).
Alternatively correlations among quadriceps muscles may reflect the need to balance mediolateral (ml) forces on the patella, so that VM and VL (that have opposite ml action on the patella) are more correlated than any other muscle pair (RF and VI produce no ml patellar forces).
Read 8 tweets
I study the illness #ME/CFS - a neuroinflammatory condition that usually begins w/ a #viral infection (sometimes a #respiratory infection!). I have argued for years that infecting #pathogens tied to the illness might persist in the central nervous system (CNS) of such patients
2/ While I realize this article is talking about acute #infection and #COVID19 - it explains that #SARS-CoV-2 “might infect neurons, raising questions about whether there could be effects on the brain that play a role in patients’ deaths:”
the-scientist.com/news-opinion/l…
3/ Matt Anderson, (one of my favorite Beth Israel pathologists!) states, “Some of the purely respiratory symptoms that you might attribute to the #disease, the inability to get air into the #lungs, might actually be defects in #respiration controlled by the #nervous system.”
Read 8 tweets
1/ #CNP Members and Organizations
"The Council for National Policy (CNP) is a body that mixes large numbers of ostensibly mainstream conservatives with far-right and extremist ideologues, mostly from the far fringes of the religious right...
splcenter.org/hatewatch/2016…
2/ "What follows is a list of 18 of the hardest-line #CNP members and links to information about them and their groups, when available, published in the past by the Southern Poverty Law Center (SPLC). Groups designated by the SPLC as hate groups are marked with an asterisk (*).."
3/
Tony Perkins
*Family Research Council
Washington, D.C.
CNP Vice President

* Designated as hate group
#CNP
Read 205 tweets
Fam! We hope y'all are doing great.

We're sorry for not posting any thread yesterday. We had a little issue but it's resolved now.

It's Day 4 of our #CancerAwareness thread. We've learnt what cancer is and how it grows.

We've also learnt about the types of tumours and today...
We'll be talking about the different types of cancer.

There are five main types of cancer ♋ but do you know what determines the types? The cells in which they grow.
Don't get it twisted. This is different from the types of tumours we talked about earlier.

#WorldCancerDay
1. Carcinoma.

This type of cancer starts in the epithelial cells (this is the layer of cells that protects🛡️organs). Carcinomas may invade ☠️ other tissues and organs and move to the lymph nodes and other areas of the body. This invasion is known as metastasis.

#Awareness
Read 10 tweets

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