Discover and read the best of Twitter Threads about #CNS

Most recents (21)

🧠Neurology Tweetorial🧠I'm often asked about localization/diagnosis in the challenging clinical presentation MULTIPLE CRANIAL NEUROPATHIES. Here is my approach, what is yours #MedTwitter #neurotwitter @NMatch2023 @rabihmgeha @DxRxEdu @caseyalbin @AvrahamCooperMD @a_charidimou?
Multiple CNs can be caused by a STRUCTURAL lesion in
👉🏼Subarachnoid space/meninges
👉🏼Skull base

🚨 Non-Structural mimics🚨
⚡️PNS (Guillain Barre)
⚡️Motor neuron dz (bulbar ALS)
⚡️NMJ (botulism, myasthenia)
⚡️Myopathy (oculopharyngeal musc dystrophy)
How to localize? #1
👉🏼Know levels of CN nuclei in brainstem

🐭Midbrain: 3, 4
🧠Pons: 6 and 7 (medial); 5 and 8 (lateral)
🧠Medulla: 5 (pain/temp) 8 9 10 (lateral), 12 medial

See diagram:
Read 15 tweets
1/@LineageCell announced it entered an exclusive option & license agreement with $ERNA for the development of novel B2M deficient induced pluripotent #stem #cell #iPSC by using Eterna’s #GeneEditing technology thus developing therapies for #CNS diseases. #BioTech #CRISPR $LCTX Lineage Cell Therapeutics, ...
2/The new cell lines - to be developed by $ERNA, will support the creation of additional product candidates at $LCTX and specifically for the treatment of central #nervoussystem #CNS disorders & other #neurology targets via Eterna’s IP #CRISPR collaboration with @FactorBio The new cell lines to be de...
3/This agreement will also allow @LineageCell to enter the #CRISPR field and will provide $LCTX an option to obtain an exclusive license to utilize & sublicense $ERNA novel #GeneEditing cell lines for #preclinical, #clinical, & commercial purposes in the field of CNS diseases. This agreement will also al...
Read 5 tweets
SEMINAL ARTICLE re: #ICD11 Chapter 08 - Diseases of the #NervousSystem 🧠

Study Title: The #leptomeninges as a critical organ for normal #CNS development and function: first patient and public involved systematic review of #arachnoiditis (chronic #meningitis). @PLOSONE

#CES- #CaudaEquina Syndrome
#DLM – Diseases of the #Leptomeninges
#ESI- #Epidural Steroid Injection
LM - #Leptomeninges
#LMF- #Leptomeningeal #Fibrosis
#NAA- #neuraxialanesthesia
PSR- PRISMA Systematic Review
#SAH- #Subarachnoid Hemorrhage
#SAS- #Subarachnoid Space

Key Findings:

1. A varyingly described, and poorly characterized #CNS disease called #arachnoiditis (aka #adhesivearachnoiditis) was exhaustively systematically-reviewed for the first time.
Read 27 tweets
Thank you to everyone who responded to our call below.

All signposts to resources/networks/committees will appear in the following Wiley texts (if proposals accepted), see thread 🧵👇🏻

#AdvancedPractice #ACP #ACCP #SCP #CNS #FCP #ANP @HonoraryGeordi_
📕#ACP at a glance - approved, due in print Autumn/Winter 2022
📙#AdvancedPractice Framework (APF) for UK practice - approved, due in print Autumn/Winter 2022
📘 APF for Acute, Emergency & Crit Care - proposal under peer review

#CriticalCare #emergencymedicine #ACCP #ECACP
📗 APF for #Paediatric & Child Health - proposal in development
📙 APF for MH, LD & Autism - initial expressions of interest (EOIs)
📕 APF for #PrimaryCare - initial EOIs
📘 APF for #Frailty , Rehabilitation & community-based care - (initial EOIs!)

#AdvancedPractice #ACP #AP
Read 4 tweets
Smt Phool Wati Devi, w/o Late S S Malhan, Leading Mechanical Engineer (LME) paid homage to her husband on #01Dec 21 at #NationalWarMemorial.
She placed petals at the 'Tablet' and laid a wreath at Tyag Chakra (1/3).

Late S S Malhan, LME served onboard #INSKhukri during the
#1971War, displayed exceptional courage & made the Supreme Sacrifice.
The wreath laying ceremony was attended by officers from IHQ MoD (Navy) (2/3).

@SpokespersonMoD @DefenceMinIndia
Earlier during the day, Adm R Hari Kumar, Chief of the Naval Staff #CNS and Mrs Kala Hari Kumar, President NWWA met the family and felicitated them (3/3).

Read 3 tweets
1/5 During today’s @OPCW #CSP-26 session, three crucial decisions were adopted:
a. CNS
b. Budget 2022-2023
c. Report on implementation of #CWC2020.

🇦🇱 supports all initiatives contributing to implementation of #CWC & eradication of use of chemical weapons worldwide.
2/5 🇦🇱 co-sponsors & voted Yes to adoption of Understanding Re. the Aerosolised Use of Central Nervous System-Acting Chemicals f/Law Enforcement Purposes.

The adoption of #CNS addresses the use of specific #CNS acting chemicals prohibited under #CWC.
3/5. 🇦🇱 is pleased to have voted in favor of the #OPCW 2022-2023 budget proposal. The budget enables #OPCW to continue its vital work in the effective implementation of #CWC.
Read 5 tweets
Admiral R Hari Kumar, PVSM, AVSM, VSM, ADC assumes charge as the 25th Chief of the Naval Staff #CNS.

@rashtrapatibhvn @PMOIndia @DefenceMinIndia @HQ_IDS_India @SpokespersonMoD @PIB_India @DG_PIB @DDNational @airnewsalerts Image
Admiral R Hari Kumar succeeds Adm Karambir Singh, PVSM, AVSM, ADC who retires upon superannuation, after an illustrious career, spanning over forty one years, in the #IndianNavy ImageImageImageImage
Read 4 tweets
Chicken Noodle Soup is a very personal and special song for both j-hope and j-hope stans. It had huge organic success and made history several times over, but it is more than simply a hit song. It is a song that j-hope had been wanting to remake for years as a tribute, (1/11)
a love note to his personal history, to the song that reminds him of how it all began for him, of his first love dance, of his home and childhood, it was a song he was determined to make happen despite setbacks and things falling through more than once, (2/11)
he never gave up on it. He knew exactly what he wanted to do with it, how he wanted to present it, what he wanted to say with it. j-hope has said how he doesn't show us his most inner feelings and worries often, some of the few times he has was related to CNS, (3/11)
Read 11 tweets
#idboardreview 20 M PLWH CD4 30 VL 500k w/ pulmonary TB at time of HIV diagnosis. Started on RIPE immediately, ART started 2 wks later. 4 wks post ART: headache & weakness. Diagnosis? #meded #idmedEd #idtwitter Image
CNS TB #IRIS Immune reconstitution syndrome: Continue ART and RIPE; NSAIDs if mild, steroids if more severe/refractory prednisone 1.5mg/kg/d x2wk f/u 0.75mg/kg/d x2wks
PLWH #HIV + active #TB #idboardreview #idmedEd #hivmedEd #IRIS
-if CD4 <50: can start ART within 2 wks of starting RIPE
-if CD4 >50: start ART within 8 weeks of starting RIPE
-pregnant+HIV+TB: start ART ASAP for maternal health
-if TB meningitis+HIV: wait 8 wks to start ART
Read 8 tweets
ATTN #CBD stakeholders: @US_FDA today holding scientific conf. on CBD/other #cannabinoids. I'll be live tweeting throughout. Not sure we'll get much insight on immediate path forward for consumer products but I'll share noteworthy observations. Agenda:
I'll be paying particular attention to @DrAbernethyFDA's remarks at 9:05a (head of #FDA's #CBD Policy Working Group) and @DThrockmortonMD's keynote at 9:15a (one of Agency's principals for regulating R&D, manufacture & marketing of #cannabis & cannabis-derived #drug products).
And we're underway! First up is Kaveeta Vasisht, MD, PharmD. Associate Commissioner for Women’s
Health and Director, Office of Women’s Health, FDA. She's noting ubiquity of #CBD products in marketplace, many of which are targeted to #women.
Read 56 tweets
@myESMO #ESMO20 as a #trainee can be #overwhelming! So many good studies, some more #practicechanging then others, if you missed some and want to understand (albeit at a simplistic #trainee level), sit back, relax and enjoy as we go through some great data #ESMO20 @OncoAlert
1. #NSCLC: 2 major studies #ADAURA #CROWN for adjuvant #EGFRmNSCLC, and advanced #ALK+ experts can provide better perspective @JackWestMD @n8pennell @StephenVLiu @AMansfieldMD @CharuAggarwalMD @NarjustDumaMD @GlopesMd @DevikaDasMD @OncoAlert
1. A) #ADAURA: Stage IB-IIIA #resected #NSCLC with #EGFRm treated with #Osimertinib vs #placebo [SOC prior to this was adjuvant chemotherapy [cisplatin-based doublet based on #LACE metanalysis-] showed improvement in #DFS @NEJM…
Read 19 tweets
Corero #CNS have sorted out their website now or at least the malware is a little more subtle - so here briefly is what they do and why I think this may be a pretty interesting UK GARP stock
Just the one tweet on what they do because, computers:

It's on-premises DDoS protection - Corero equipment (powered by $JNPR's MX - important) sits at the edge of the network, inspects and mitigates attacks.

Anything less than 10GB is dealt with locally. More, goes to cloud
Why they're interesting is essentially that there has been quite a sudden step change in their performance.
Read 8 tweets
What's up with $SGMO valuation? This thread will try to show some history and the setup for what I still hope to be an outsized move. First worth noting that news will always trump technicals. First here is a month chart I've been using for the company 1/
This being a 10 year chart, it doesn't show how long $SGMO has been around but it does show virtually no trading volume and a 3 yr ceiling on the price as they were in early development stage while trying to get ill-chosen indications into pre/clinic 2/
The first wave $SGMO rally started in 2013 when the ceiling was broken. The company was talking up #GeneEditing #GeneRegulation #HIVcure and #diabetes None were ready but the volume picked up and the first big rally ensued going from around $9 to $20 3/
Read 13 tweets
If you really want to make a change in the world, do something hard like #nonviolent #resistance. Read up and learn #satyagraha or change. It takes #strength & #courage; physical force is forbidden even in the so-called most favorable circumstances.…
If your cause is #righteous, Gandhi believed, the movement would speak for itself.

My personal justification for it is #psychological/#neurological (#CNS/#HPA).

If you use #violence, well the one with the biggest #ego or the biggest ego-extension (guns, tanks, war) will win.
Removing tools of violence (words, arms) from the equation, you form a mirror.

It's not easy though. You'd have to refine/drop/manage/elevate past your own #ego.

People - depending on personal history & psychology - sometimes become enraged at what they see in the #mirror.
Read 8 tweets
1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
Read 10 tweets
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Read 6 tweets
A prominent theory in #neuroscience hypothesizes that the #CNS generates muscle activity to simplify #motorcontrol, so that muscles with similar task actions are controlled as a single functional unit. Our results do not support this hypothesis! A thread.…
This theory predicts that correlations between muscles that have consistent task actions (e.g. the vastii muscles, VM, VL and VI) should be equally strong, and stronger than their correlations with task-inconsistent muscles (e.g. RF, that extends the knee and flexes the hip).
Alternatively correlations among quadriceps muscles may reflect the need to balance mediolateral (ml) forces on the patella, so that VM and VL (that have opposite ml action on the patella) are more correlated than any other muscle pair (RF and VI produce no ml patellar forces).
Read 8 tweets
I study the illness #ME/CFS - a neuroinflammatory condition that usually begins w/ a #viral infection (sometimes a #respiratory infection!). I have argued for years that infecting #pathogens tied to the illness might persist in the central nervous system (CNS) of such patients
2/ While I realize this article is talking about acute #infection and #COVID19 - it explains that #SARS-CoV-2 “might infect neurons, raising questions about whether there could be effects on the brain that play a role in patients’ deaths:”…
3/ Matt Anderson, (one of my favorite Beth Israel pathologists!) states, “Some of the purely respiratory symptoms that you might attribute to the #disease, the inability to get air into the #lungs, might actually be defects in #respiration controlled by the #nervous system.”
Read 8 tweets
1/ #CNP Members and Organizations
"The Council for National Policy (CNP) is a body that mixes large numbers of ostensibly mainstream conservatives with far-right and extremist ideologues, mostly from the far fringes of the religious right...…
2/ "What follows is a list of 18 of the hardest-line #CNP members and links to information about them and their groups, when available, published in the past by the Southern Poverty Law Center (SPLC). Groups designated by the SPLC as hate groups are marked with an asterisk (*).."
Tony Perkins
*Family Research Council
Washington, D.C.
CNP Vice President

* Designated as hate group
Read 205 tweets
Fam! We hope y'all are doing great.

We're sorry for not posting any thread yesterday. We had a little issue but it's resolved now.

It's Day 4 of our #CancerAwareness thread. We've learnt what cancer is and how it grows.

We've also learnt about the types of tumours and today...
We'll be talking about the different types of cancer.

There are five main types of cancer ♋ but do you know what determines the types? The cells in which they grow.
Don't get it twisted. This is different from the types of tumours we talked about earlier.

1. Carcinoma.

This type of cancer starts in the epithelial cells (this is the layer of cells that protects🛡️organs). Carcinomas may invade ☠️ other tissues and organs and move to the lymph nodes and other areas of the body. This invasion is known as metastasis.

Read 10 tweets
Team studies brain autopsies of elderly subjects w/ molecular tools, immunohistochemistry + microscopy👉Detect Parovirus B19 in #brain tissue from encephalopathy + control groups “suggesting #virus persistence within the CNS throughout
the host’s lifetime”… ImageImageImageImage
The study also found that, in the #brain, Parvovirus 19 persisted inside microglia + astrocytes 👉 But, the #virus was most identified as infecting oligodendrocytes in the white matter of the brain’s frontal lobe:… ImageImageImage
I work w/ #ME/CFS physician Roger Mazlin 👉 Mazlin has been treating patients w/ HIV + ME/CFS since the 1980s 👉 He’s currently “finding higher levels of #Parvovirus 19 in his ME/CFS subjects than ever before in his career”
Read 4 tweets

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