Discover and read the best of Twitter Threads about #COVIDVariants

Most recents (20)

🧵 A little vignette for #ASCO22 attendees & esp speakers/chairs. Today I spoke in an Ed session. E350 is small enough I could see faces. When we began, most were in 😷, but I counted 11 who weren’t. One had a drink. The rest didn’t appear to be eating/drinking. Importantly… 1/
a few people (not sure if in 😷 or not) were coughing. That’s something you always hear, but it takes on added significance in a #pandemic because #COVIDisAirborne & current #Covidvariants spread as easily as measles, the most contagious respiratory pathogen on earth. /2
Before I began my talk, I called attention to the fact that I would be continuing to #WearAMask while speaking. #Covid19 doesn’t care that I’m at the #ASCO22 podium. I said I was speaking masked to model the #OncTwitter behavior I hope to see. /3
Read 8 tweets
We have either rapid re-infection, or rebound #Covid19 after Paxlovid, in my own 🏡 . Vaxxed & boosted. Symptoms & rapid test pos 5/2, 5d of Pax 5/4-5/8, all symptoms gone, neg rapid test x 2 5/8 & 5/9.

5/16 new symptoms & RAT instantly pos (📸). Our #MedTwitter 🏡 is weary. Image
By the way, the right answer is not “So Paxlovid doesn’t work.” It works very well to ⬇️ risk of severe illness, which matters a lot. And right answer is not “so let’s just give 10d.” Right answer is we need data to understand this phenomenon & direct rational antiviral use.
I’m sharing this because:
👉Anecdotes can generate scientific hypotheses that THEN MUST BE STUDIED WITH RIGOR &
👉The public needs to know for #publichealth reasons that, one way or another, we can end up symptomatic & contagious again a wk after apparent #COVID19 recovery.
Read 11 tweets
🧵As a scientist & physician, when our #pandemic predictions are off, I think it's important to circle back & analyze why. In late Dec 2021, I tweeted a🧵predicting widespread disruption of everything from health care & pharmacies to grocery stores & schools in Jan/Feb '22. 1/x
The reason for my prediction was the pattern of a huge spike in #COVID19 cases the prior winter (driven in part by holiday travel) & the fact that #omicron was considerably more contagious than prior #COVIDvariants & more able to evade immunity from vaccines or prior infxn. 2/x
The pace in growth of cases in Dec '21 in countries w/ early #Omicron outbreaks was stunning. The graphs were vertical. In the US, we appeared on target to have >500K cases/d in the US. We had no idea yet how long the surge would last. 3/x
Read 18 tweets
🧵 I’m not sure what I’m about to say has been made clear to ppl w/o a science or #MedTwitter background. It may be a genuine source of confusion (ie good faith questions), so here goes. Many are saying “If #Omicron makes a given person less sick (which appears to be true)…” /1
“Shouldn’t we just go ahead & get it over with? You know, masks off & almost everyone gets infected & then we’ll be done with it?” I get why someone might think or ask that. It makes sense. But it’s not the right thing to do, & here’s why. /2
There are the things you have prob heard before: even a tiny % of infected ppl dying is a lot of dead if most of the 🇺🇸 (or the 🌍 ) gets #Omicron. And there are overwhelmed hospitals, which cause deaths for other reasons. But this 🧵 isn’t about any of that. /3
Read 23 tweets
🧵 Your risk of dying if you get #Omicron in the next few wks as opposed to a few months from now will be dramatically different. We are facing huge surges in Jan that will make it hard to get seen in an ER in a timely fashion & even harder to get admitted to a hospital.
2/ Should you be fortunate enough to find a bed, you will have drs & nurses overwhelmed with patient volume, who will have very limited time to spend w/ you. Dr to patient (& nurse to patient) ratios will be unsafe, like unthinkable in pre-#pandemic times. #Omicron #MedTwitter
3/ This alone will dramatically increase your odds of death. That’s been seen in the prior surges. With #Omicron, the # falling ill at once is 🚀 off the charts. I’m seeing attack rates of 75-100% even in fully #vaccinated (& some #boosted) gatherings & households. #MedTwitter
Read 13 tweets
📣#Preprint #COVID19 #ConvalescentPlasma
📌RCT (N=1.2K)
📌Outpatients age 18+
📌High-titer CCP (>1:320) vs placebo plasma w/in 9d of symptoms
📌Primary endpt: Hosp/death by d28
📌CCP 🏆: 54% ⬇️, driven by non-ICU hospitalizations (NNT=29); HR 0.46, p<.01
medrxiv.org/content/10.110…
2/ A few important points about this #COVID19 #convalescentplasma trial
📌High-titer CCP was much higher than that used in some other studies (median titer of >1:14,580 & 95% had >1:4820)
📌Median days to plasma: 6d
📌53 of 54 hospitalizations were in unvaxxed (#GetVaccinated!)
3/ 📌 Only 3 deaths in post-hosp period, all in controls
📌 Few #COVID19nCancer or #immunocompromised
📌 Study used #convalescent plasma mostly from Apr-Dec 2020 (ie pre-#vaccine availability)
📌Would *predict* CCP from #vaccinated to perform well vs #Omicron & #covidvariants
Read 9 tweets
🧵I have to say it: Christmas break is going to be bad. I'm watching confirmed #COVID19 cases⬆️ exponentially at our highly-#vaccinated school w/ a #MaskMandate & HEPA filters in every class. Make a plan now for how you'll handle Xmas & #quarantine when someone gets #Omicron.
2/ Think about how you can create a separate space for the person(s) infected. Remember #OmicronIsAirborne. Pick a rm w/ windows to open & its own door if your home allows. Today put a fan there that can be used to improve air exchange. Put a 🌡️, an O2 sat monitor, good masks.
3/ Go get a MERV13 filter for your HVAC at Home Depot or Lowe's or online. While here, get the stuff to build a simple, inexpensive, highly-effective Corsi-Rosenthal box. You can see what this is here. Build it now so it's ready.
Read 15 tweets
I know personally 3 people receiving monoclonal antibodies this evening. All have had 3 doses of #COVID19 #vaccine or prior infection + 2 doses of vaccine. All are careful. They all have risk factors, but all are pretty symptomatic. Jan is gonna be…rough. #MaskUp. #Omicron
Tweet 2: A lot of people seem to be panicking based on this anecdote. Panic is NOT productive. Instead you need to calmly plan & act to reduce your risk. These are some effective things you can do right now:
👉Upgrade your masks. No more cloth alone. Best is N95/KN95/KF94...
Tweet 3: As an alternative to N95/KN95/KF94, if you can't tolerate those or don't have them, I rec a surgical mask (ASTM level 3, 3-ply is great) w/ cloth mask over it. Read this: scientificamerican.com/article/why-we…. The non-profit @projectn95 has vetted, affordable PPE including masks.
Read 13 tweets
What hope is there for the health & safety of school children in🏴󠁧󠁢󠁥󠁮󠁧󠁿 when the chair of @CommonsEd continues to promote & support the views of @UsforThemUK & @lensiseethrough which are ANTI-#COVID MITIGATION on every level!
1/14🧵
Whilst @educationgovuk policy on #COVID19 mitigations in schools is so heavily influenced by this group, & others, there is little chance of any tangible change before 🏴󠁧󠁢󠁥󠁮󠁧󠁿schools reopen in September.

16 months in to the pandemic, children here are FAR LESS PROTECTED, not more!
2/
Does @halfon4harlowMP realise that school children are being unnecessarily exposed to #coronavirus as part of the government’s #HerdImmunityByInfection “strategy” which has been internationally condemned as an unscientific & barbaric way to proceed?

#Murderous #COVID19UK
3/
Read 15 tweets
1/ #PrimeMinister & #HealthSecretary,

I just want to clarify how I can keep myself & my family safe from the #COVID19 surge in cases in our area?

I live & work in Newcastle, where cases are now well > 800 per 100,000, a real #COVIDHotSpot!

@BorisJohnson @sajidjavid
2/ How do you suggest advice to “proceed with caution” & “remain vigilant” will stop my #NHS colleagues & I from succumbing to #COVID19 as frontline HCWs regularly exposed to #coronavirus, now that 😷s are OPTIONAL in many places & virtually all restrictions will end in 7/7?
3/ Which exact bit of your roadmap/unlocking is still “following the science”?

The science that quite clearly says the best way to protect both health AND the economy PLUS prevent new #covidvariants arising is to KEEP COMMUNITY TRANSMISSION & CASES LOW?
Read 13 tweets
Dep of Health the B.1.351 prevalent in SA has more mutations than the B.1.617 which is dominant in India, SA is still able to control the spread of B.1.351 in SA & bring the wave down to a plateau. #Covid19 #CovidVariants
Dep of Health says we have no need to panic about the B.1.617 which is dominant in India because, as with any variant of the #Coronavirus the treatment is the same and the way we prevent spread is the same.
Health Minister Dr Mkhize says scientists are working hard to examine the samples taken from patients that traveled from India. One of the sequences of a traveller has been completed and it turned out to be the B.1.351 variant- the one that is circulating here in South Africa.
Read 5 tweets
数々の賞を受けた東京在住のジャーナリストであり「”ジャパニゼーション”~世界は日本の『失われた10年』から何を学べるのか?」の筆者である @WilliamPesek さんによる入魂の記事。

「東京の "ゾンビ五輪 "に歴史は寛容ではないだろう 介入すべき時が来た」
s.nikkei.com/3cT42a7

#ゾンビ五輪
1年前、失言癖のある麻生太郎副総理は、第二次世界大戦中の1940年に東京五輪が中止され、1980年にモスクワ五輪が大規模なボイコットを受けたように、2020年の五輪を「呪われた大会」と呼んだ。その後、新型コロナが進んでも、#Tokyo2020 はアンデッドなイベントとなってしまった。
上層部の組織的な支援に支えられる死に体の会社のように #Tokyo2020 は伝統の生ける屍となった。日本がソフトパワーの全てを無駄にしてしまう前に真剣に介入すべき時が来た。このスーパースプレッダーイベントの「オウンゴール」に値する行為を止めるよう呼び掛ける提言は、私が初めてではない。
Read 19 tweets
Another excellent, practical resource for school heads to use to improve mitigation w/in UK schools.
As approx 10M ppl mix w/ virtually none of this in place it’s hard to believe that it won’t result in kicking off another #COVID19 surge w/ a BIG BANG! 1/8
Everyone able to effect change should read it & consider which side of the DEBATE they wish to be in over next few months.
False reassurances about the use of #lateralflowtests by the government & those prepared to support them on TV/media have attempted to hide to truth. 2/
Celebrity #antimaskers have continued to apply pressure & w/ the help of #Tory backed #UsForThem have successfully made #Masksinclass an OPTION, whilst children across the world, as young as 6 #WearAMask at school w/ out complaint or issue.
Dangerous #BritishExceptionalism! 3/
Read 8 tweets
Dear @susannareid100 & @piersmorgan
In advance of your program tomorrow I wonder if I could ask for your help?
If any celebrity duo can make this happen, it is you two!
The ROAD MAP is here & there’s a light at the end of the tunnel.
There are many positives in the #PrimeMinister’s cautious approach but the BIG BANG opening of English schools on 8th March with very few added mitigations is reckless & irresponsible, risking everything we have collectively achieved so far.
We all know that schools & early years settings are risky places to work in. Whatever the stats tell us about teachers en masse, I feel that for individual staff, being forced to work in crowded, poorly ventilated rooms w/ many others protected by little #PPE , is a VERY BIG ASK!
Read 10 tweets
This is plea to all Headteachers regarding the imminent full opening of UK schools.

If we remove from the debate HOW MUCH children transmit/spread #coronavirus WITHIN schools, we all accept that they do spread it to a greater or lesser degree.
Fact!
1/8🧵
Children do not exist in isolation!
Every day they mix with their families & friends & during the school day they mix with many teachers & staff.
Fact!

So the word BUBBLE in the school context is UTTER NONSENSE! 2/
The government & #DfE have rejected virtually every mitigation proposed by #SAGE, @IndependentSage & @neu & we’re told the @CMO_England is v uneasy about a BIG BANG reopening.

You don’t have to be a scientist or medic to understand this re risk in various settings👇🏼.
3/ Image
Read 9 tweets
1/14 Morning @SophyRidgeSky, just watched the interviews w/ @DominicRaab @annelongfield @timspector & @bphillipsonMP re #schoolsreopening fully on 8th Mar.

Discussions focused on dates, primary vs secondary, catch up plans, mental health concerns, vulnerable children....
2/But NOT A SINGLE MENTION OF #coronavirus MITIGATION INSIDE SCHOOLS!

Has the MSM been banned from mentioning mitigation measures?
Are British children/teaching staff different to those across the world?
Do they have SPECIAL IMMUNE SYSTEMS?
3/NO FIGURES on how many children get #COVID19?
NO MENTION of how many become seriously ill, are hospitalised or die?
Absolutely NO WORD about the 1 in 7 or 8 children who get #LongCovid!
NO ADVICE for parents of children w/ diseases like Diabetes, severe Asthma etc.
Read 14 tweets
@dgurdasani1, you are a legend 👏!

PLEASE please listen to this from 07.20-40.30.
You will not regret it.

It clearly demonstrates the dangers of those without any CLINICAL knowledge & expertise being able to make crucial decisions that effect so many lives.
1/15 a thread.
Questions for the MODELLERS & MPs...

Have you actually seen a child poorly w/ #COVID19? It can be extremely frightening for both child & parents.

Have you seen/spoken to the parents of any children suffering w/ #LongCovid?
Why not listen to what parents & Drs are saying? 2/
#COVID19 is a multi-system disease with w/ many negative outcomes other than hospitalisation or death.

IT IS NOT FLU!

#COVID19 IS NOT FLU!

#LongCovid in both adults & children can be v debilitating & there’s currently v little knowledge about the long term prognosis. 3/.
Read 15 tweets

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