Discover and read the best of Twitter Threads about #CancerNeuroscience
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Patients with #glioma often experience altered cognition but it was unknown whether tumors remodel or destroy neuronal circuits in the human brain. New, open access #CancerNeuroscience paper: nature.com/articles/s4158….
In our study led by talented @NeurosurgUCSF post doc @SarithaKrishnaa and collaborators @michelle_monje, @DavidJBrang @LabRaleigh @AnnetteMolinar2, we found that glioblastomas remodel circuits.
Intraoperative recordings in awake people with left hemisphere #GBM show us that speech production activates glioma-infiltrated cortex, and GBM remodels speech circuitry so that producing speech activates all of the glioma-infiltrated cortex.
How do glioblastoma invade and colonize the entire brain ?
Overlaying molecular, structural and functional data helped us to uncover three layers of neuronal mechanisms driving glioblastoma invasion (authors.elsevier.com/c/1fVaEL7PXipIV). A thread 🧵: (1/24)
Overlaying molecular, structural and functional data helped us to uncover three layers of neuronal mechanisms driving glioblastoma invasion (authors.elsevier.com/c/1fVaEL7PXipIV). A thread 🧵: (1/24)
Previously, we saw a subpopulation of glioblastoma cells was connected with each other via gap junctions while other tumor cells appeared unconnected . The tumor-tumor network was resistant toward therapy. But what is the role of the seemingly unconnected tumor cells ? (2/24)
To characterize molecular and functional glioblastoma cell states we used a combination of in vivo imaging and single cell RNA-sequencing with the dye SR101 that could distinguish tumor-connected and and tumor-unconnected glioblastoma cells. (3/24)
