Discover and read the best of Twitter Threads about #ChAdOx1

Most recents (11)

A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
Shocking! Can’t the rich countries postpone vaccination of their less susceptible population & donate excess quota of vaccines to the underprivileged, LMICs of Africa?
Need such policies to spare more vaccine doses for the needy. We now have plenty of data on the futility of the 2nd vaccine dose to the pre-infected, seropositive individuals

thelancet.com/journals/ebiom…
This research has relevance to India also.
A single dose #ChAdOx1 nCoV-19 vaccine serves as an effective immune booster after priming with natural #SARSCoV2 infection up to at least 11 months post infection.

medrxiv.org/content/10.110… ImageImage
Read 5 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Here's the latest episode of #COVID19 : Updates from Singapore
This series of webinars is brought to you by @WHOGOARN and @NUSMedicine

It's hosted by @profdalefisher , Prof. David Allen, and Dr. Louisa Sun
Watch here:
Read 70 tweets
Egun hauetan irakasleok #AstraZeneka / #Oxford #txertoa jasoko dugu (#AZD1222 izena duena) Beste izen luzeago bat ere badu: #ChAdOx1 nCoV-19 badakizue izenaren jatorria? Badakizue zer "sartuko diguten"? haritxo bat egingo dugu? #zientzia #COVID19 #haria 🧵
Oxfordeko unibertsitateak eta AstraZenekak garatu duten txertoa da hau eta horretarako teknologia ezagun batean oinarritu dira: Beste birus bat “ibilgailu”🚗modura erabilita Covid19 gaixotasuna sortzen duen #SARSCoV2 birusaren “zatitxo” bat 🧬sartu gure organismoan
Zein beste birus? 🤔Sars-cov-2 ren zein zatitxo? 🤔Galdera horiek badituzu buruan bueltaka… jakinmina piztu dizut? Saiatuko naiz maila mantentzen jejeje Aurrera!! Jarrai dezagun!!
Read 14 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
Pues hispanoamérica, especialmente 🇲🇽 y 🇦🇷, decidieron también apostar por la #vacuna 💉 más prometedora: la #ChAdOx1 de la @UniofOxford. En cambio 🇧🇷, uno de los países más afectados por el #Covid_19, aposto por la vacuna de 🇷🇺 que no tiene evidencia que la respalde 😪
La apuesta se da x 3 razones:
1. @Fund_CarlosSlim es garante de la inversión.
1. @AstraZeneca tiene en Garín 🇦🇷, una planta de 10 K m², donde hacen anticuerpos monoclonales.
2. Y porque en 🇲🇽, llegó a un acuerdo con @LiomontLab y su centro de distribución robotizado en Ocoyoacac Image
Es decir, es una apuesta de la INICIATIVA PRIVADA, que tuvo a bien involucrar a los Gobiernos de ambos países 🇦🇷 y 🇲🇽. #Vacuna #Covid_19
Read 3 tweets
Our ChAdOx1 nCoV-19 vaccine study is now published in Nature! Huge thanks to all involved. #SARSCoV2 #vaccine #chadox1 nature.com/articles/s4158…
Compared to the bioRxiv publication, we have now included a prime boost group, and 3 more control animals
The efficacy is striking in the lungs - no pneumonia after a single shot, no to very limited viral RNA in BAL
Read 8 tweets
Thanks to @JanetDaly5 for flagging this. First animal data from #chadox1 #SARSCoV2 vaccine. Not sterilising immunity, but reduced viral load and pathogenesis, with half dose, BUT very quick challenge 4 week. (recall questioning this previously):
biorxiv.org/content/10.110…
1/n
worth considering these data in detail; and what they might or might not mean
2/n
Firstly, the challenge dose. This was a relatively large amount of virus, BUT for people exposed to virus for considerable periods of time and/or large amounts (household member or healthcare worker) then protection against higher viral load exposure is relevant.
Read 8 tweets
"The Lancet‘s fraudulent concealment of genetics, and its own conflicting interests, while condemning #coronavirus conspiracy theorists, gives the appearance of “crisis capitalism,” and complicity in the COVID-19-SARS/HIV-1 #Wuhan ‘Event 201‘ biocrime." Image
The 'Scientific' arguments going on behind the scenes on #Covid_19 should be a wake-up call to the 'TRUE' dangers the world is being exposed to! 'BOTH' sides of the argument are labelling the other 'Conspiracy Theorists'. Only one of them can be! Image
The Lancet writes that "Conspiracy theories do nothing but create fear, rumours, and prejudice...." #Covid_19 Image
Read 52 tweets

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