Discover and read the best of Twitter Threads about #ChariteVirology
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What? The Director of #CharitéVirology Berlin, you say?
Well fancy that..
I'm going to have to go back and take a little look again
Excited to share our new preprint together with @menz45, @vmcorman and many others in which we show that #SARSCoV2 Beta elicits potent lineage-specific and cross-reactive antibodies! 1/n
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Why are we interested in Beta? RBD Beta can be considered „antigenically most distant“ from the original strain and it contains mutations reducing neutralization of many #SARSCoV2 antibodies. But how do antibodies elicited by Beta look like? 2/n
Thousands of monoclonal antibodies against the original RBD isolated in the last 2 years provide a reference frame to look at differences and similarities, e.g.: Are potent and abundant VH3-53/VH3-66 antibodies that are normally sensitive to mutations in Beta still elicited? 3/n
Just uploaded the first #SARSCoV2 sequence imported from Italy to Germany on #Gisaid. First sequence from present Italian clusters AFAK. Outstanding team @ #charitevirology.
Note that 3 SNPs (positions 241, 3037, 23403) are uniquely shared with Munich cluster virus. Virus also groups with Munich sequence in tree. This is not sufficient to claim a link between Munich and Italy.
Why: viruses are still undersampled, common sources may exist, Italian virus has 5 more SNPs that are not shared with Munich sequence (10265, 14408, 28881,-2,-3; reference: EPI_ISL_40212).
