Discover and read the best of Twitter Threads about #ChronicInflammation
Most recents (2)
🧵 An absolutely fascinating talk by William Gunning @Dysautonomia conf - Innate Immune system Activation in PoTS. A complex topic made easy to understand by a Prof in pathology & it makes a lot of sense to me, it’s like seeing another puzzle piece! Here’s some interesting
2/points:
Platelets are very important in innate immunity & homeostasis (still being debated)
Platelets have over 400 biochemicals!
Serotonin is produced in the gut & pooled in platelets for delivery around the body (outside of CNS 99% of serotonin is in the platelets)
Platelets are very important in innate immunity & homeostasis (still being debated)
Platelets have over 400 biochemicals!
Serotonin is produced in the gut & pooled in platelets for delivery around the body (outside of CNS 99% of serotonin is in the platelets)
3/Symptoms of low seratonin are commonly seen in PoTS
Platelets secrete a number of pro-inflammatory cytokines & chemokines
All cells secrete chemicals that recruit inflammatory cell response
Dr Gunning has done some studies:
- one showed significant ⬇️ in dense granule number
Platelets secrete a number of pro-inflammatory cytokines & chemokines
All cells secrete chemicals that recruit inflammatory cell response
Dr Gunning has done some studies:
- one showed significant ⬇️ in dense granule number
Cool #Senescence paper #2, in @JCI_insight: insight.jci.org/articles/view/….
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
@marissa_schafer, Xu Zhang, @NKLeBRASSEUR & team dive into the details of SASP, the Senescence Associated Secretory Phenotype first discovered in the Campisi lab @BuckInstitute.
SASP is a prime suspect for how #Senescent cells cause #Inflammation, #Cancer and #Fibrosis. But SASP is a mix of many secreted proteins, so the @MayoClinic looked closely at 24 factors.
1st, they show which factors are secreted by different cell types (in culture).
1st, they show which factors are secreted by different cell types (in culture).
Next, and more exciting, they measured which SASP factors increase with age in human blood. #ChronicInflammation is an important mechanism of aging, but really defining #ChronicInflammation is hard and often not even attempted. So this detailed analysis is great.
