Discover and read the best of Twitter Threads about #ColCORONA
Most recents (5)
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
📢 Remarque sur la communication de l'essai #ColCORONA
La Colchicine entraîne une réduction de 25% des hospitalisations si on communique en terme de risque relatif mais ça équivaut à éviter 1 hospitalisation pour 80 personnes traitées si on prend un taux d'hospitalisation de 5%
La Colchicine entraîne une réduction de 25% des hospitalisations si on communique en terme de risque relatif mais ça équivaut à éviter 1 hospitalisation pour 80 personnes traitées si on prend un taux d'hospitalisation de 5%
Ici l'hospitalisation est un événement rare (~5% dans l'essai), on peut approximer le rapport des chances "Odds Ratio" par des risques relatifs (RR)
Chez les patients avec test confirmé : OR=0.75, soit une réduction du RR de -25% entre les groupes traités vs non traités
Chez les patients avec test confirmé : OR=0.75, soit une réduction du RR de -25% entre les groupes traités vs non traités
▪️ En différence de risque absolu, ça revient à une réduction absolue du risque (RAR) de -25%*5%=-1,25%
ça fait moins sexy ✨
▪️ Si on exprime ça en Nombre de sujets à traiter (NNT), c'est l'inverse du RAR, soit 1/0,0125=80
➡️ On évite 1 hospitalisation tous les 80 traités
ça fait moins sexy ✨
▪️ Si on exprime ça en Nombre de sujets à traiter (NNT), c'est l'inverse du RAR, soit 1/0,0125=80
➡️ On évite 1 hospitalisation tous les 80 traités
To cap a weekend of #colchicine-induced GI upset from the press release of #ColCorona trial relative %s approaching statistical significance for #COVID19... started getting messages regarding #Maduro's announcement this evening of #Carvativir, Jose Gregorio's miraculous drops
He plans to distribute the new wonder anti-#COVID19 treatment widely throughout #Venezuela this week. He mentioned the drug is given as drops sublingually every 4 hours...
efectococuyo.com/salud/carvativ…
efectococuyo.com/salud/carvativ…
The news on #Carvativir is likely to generate multiple creative responses from many, likely to compete with the #BernieMeme from the last few days.
If you look closely at the bottle, #Carvativir's active ingredient is #isotimol (#isothymol), at a concentration of 5mg/mL.
If you look closely at the bottle, #Carvativir's active ingredient is #isotimol (#isothymol), at a concentration of 5mg/mL.
