Discover and read the best of Twitter Threads about #ConvalescentPlasma

Most recents (24)

📣#Preprint #COVID19 #ConvalescentPlasma
📌RCT (N=1.2K)
📌Outpatients age 18+
📌High-titer CCP (>1:320) vs placebo plasma w/in 9d of symptoms
📌Primary endpt: Hosp/death by d28
📌CCP 🏆: 54% ⬇️, driven by non-ICU hospitalizations (NNT=29); HR 0.46, p<.01
medrxiv.org/content/10.110…
2/ A few important points about this #COVID19 #convalescentplasma trial
📌High-titer CCP was much higher than that used in some other studies (median titer of >1:14,580 & 95% had >1:4820)
📌Median days to plasma: 6d
📌53 of 54 hospitalizations were in unvaxxed (#GetVaccinated!)
3/ 📌 Only 3 deaths in post-hosp period, all in controls
📌 Few #COVID19nCancer or #immunocompromised
📌 Study used #convalescent plasma mostly from Apr-Dec 2020 (ie pre-#vaccine availability)
📌Would *predict* CCP from #vaccinated to perform well vs #Omicron & #covidvariants
Read 9 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
This thread is directed to all of you searching for plasma donors and/or amplifying requests for plasma donation, but most importantly, for physicians suggesting plasma donation, or patients’ families demanding #ConvalescentPlasma treatment for their loved ones.
Over the past year and more, we have had #ConvalescentPlasma dominating conversations about #COVID_19 treatment. Families have run from pillar to post trying to find a compatible donor. We’ve had celebrities urging people to donate.
Importantly, we’ve had heartbroken families feel guilty about not having been able to identify a suitable donor in time to save their loved one’s life. This thread is meant for all of them.
Read 17 tweets
IMPORTANT THREAD on #COVIDTreatments - What Works & What Does not. Will be an ongoing threat.

Start with Dr Zarir Udwadia of Mumbai.
Link to Dr Udwadia's Video


1st Point: 90000+ Medical papers on Covid. UNFORTUNATELY, big divergence in Observational Studies impact and Real World impact of a rigorous RCT
RCT is Randomized controlled trial.
A Good website is Covid19Primer.com

2) What Works ?
(A) Steroids are essential. #DEXAMETHASONE 6mg/day for Critically ill Covid Patients. Reduces Death by 33/20% for Patients on Ventilators & Oxygen. ImageImageImage
Read 19 tweets
I know the #COVID-19 numbers in India are not looking good, but here are my (not so) random thoughts on it Image
We have 2 options – one, rant & rail against the ‘system’ and lament how it has let us down; second, do whatever we can to avoid getting infected & if infected, minimize adverse consequences to ourselves & others. If you belong to the first, you can stop reading now
How can we avoid getting infected? There’s no magic bullet, I’m afraid. This is primarily a “stick to the basics” approach. More difficult than it sounds.
Read 25 tweets
Given the full community spread of #SARS_CoV_2, it is time to stop incessant #RTPCR testing in asymptomatic people, so called "healthy sick" , and save resources. Start early Rx with ivermectin+budesonide+Zn+ chicken soup+kadha or whatever in mild to moderate #Covid_19 cases. 1/n
And, reserve #ICUs for serious #Covid patients only. Start triage and stop the use of #Remdesivir and #convalescentplasma therapy ASAP, as it doesn't help save lives. Don't hospitalize maniacs hyperventilating due to fear in the Covid ward and shift them to counseling ... 2/n
.. for managing hyper active state of mind & deactivate their social media accounts + WhatsApp. Public health intervention with #VitaminD 60k once week for 4 weeks starting now and not while patient is sick with #Covid By then it will not help to build adequate VitD reserve..3/n
Read 6 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
Happy to be back at @UHWI_JA for my 4th #ConvalescentPlasma donation; a full 6 months since I had COVID19 my antibody titer is still very high and I am still able to donate. Image
Couple more pics of the Convalescent Plasma donation process. ImageImage
For anyone wondering what they're seeing in this picture the machine on the left is a cardiac ultrasound machine, which was used to place the access line (the one higher up my arm, which uses a larger bore cannula). The machine on the right is the apheresis machine. 1/
Read 7 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
@azlawhealth & #CUPAEthics & @JLME_ASLME joint webinar on real world data from #ExpandedAccess (using #ConvalescentPlasma as a treatment for #COVID19 as a case study) featuring @DrMJoyner @tomwatson83a @HollyLynchez @ClaudiaHirawat @trsklar & more on now!
@DrMJoyner the convalescent plasma being used was an “uncharacterized product at unknown dose”
Read 13 tweets
Day one today of @OversightDems #drugprices hearing at 10amET: $BMY & its Celgene unit & $TEVA.
oversight.house.gov/legislation/he…

Also, at 11:30amET, @EnergyCommerce #COVID19 #vaccines hearing: energycommerce.house.gov/committee-acti…
.@RepMaloney notes that anyone in the @OversightDems room not wearing #masks will not be recognized at today's #drugpricing hearing.

#drugprices $BMY $TEVA
.@RepMaloney starts out playing clip of @RepCummings, who died last year before he could convene today's #drugpricing hearing.

He notes #pharma one of most powerful/profitable industries in the world.

#DrugPrices #pharma #biotech
Read 51 tweets
.@GOPHELP @HELPCmteDems hearing now underway with #NIH Fauci, @SteveFDA, @CDCDirector Redfield & @HHS_ASH Giroir on U.S. #COVID19 response.

.@SenAlexander notes its final hearing as chairman.

#FDA #CDC #NIAID #vaccines #TestingTestingTesting
.@SenAlexander notes development & manufacturing of #COVID19 #vaccines are being done in parallel.

"The risk is taxpayer money."
Read 67 tweets
I’ve been watching with increasing concern at the trend of new daily diagnoses of COVID-19 in India over the past two weeks. To me, this reflects general public mood which seems to have begun to ignore the threat this virus poses. Thread
While the good news is that our death rates haven’t been as bad as some of the other countries (we might debate the accuracy of death reporting), but with a population of 1.35 billion people, the absolute numbers are still sobering. And rural India is just beginning to get hit
What I’d like to see is reliable “Excess mortality” and a P score which will quantify the true impact of the pandemic on deaths in India. We know that Mumbai had an excess mortality of 13000 deaths between Apr and Jul 2020. We don’t yet have data for India as a whole.
Read 23 tweets
If a #COVID19 vaccine is approved in 2020, 65% of U.S. voters surveyed believe it would be rushed without enough testing and 58% said they would wait to get the shot, while 21% said they would never get it, according to a Sept. 6 CBS News poll.

#vaccines #FDA #pharma #biotech
.@SenWarren said this morning she plans to question @NIHDirector Collins & @Surgeon_General Adams on how the Trump administration will ensure the American people can get a safe, effective vaccine for #COVID19 free of politicization and interference by Trump.

#vaccines #FDA #NIH
Read 63 tweets
.@theNASEM holds its public online "listening session" today starting at noon E.T. to discuss yesterday's draft on equitable #COVID19 #vaccines allocation.
nationalacademies.org/event/09-02-20… #FDA #CDC #NIH

Read my story free here 👇
.@VictorDzau: Initial #COVID19 #vaccines doses will be limited, at least in beginning.
Scarce vaccines will need to be allocated in ways that are thoughtful, strategic/fair.
Important we have a well-thought out framework
Objective/transparent/trusted/independent
#vaccineframework
WILLIAM FOEGE: This is a draft.
Meeting today because want final product to be better.
This is a fast draft!
Uncertainties we had were overwhelming.

We did the best we could.

We started w/ ethics/equity before we went to the science.

#vaccineframework #COVID19 #vaccines
Read 57 tweets
Here it is: @SteveFDA told @FT he was was "prepared to authorize a vaccine before Phase 3 clinical trials were complete, as long as officials believed the benefits outweighed the risks."

How will #FDA determine #COVID19 #vaccines efficacy/safety benefits without phase 3 trials?
.@SteveFDA tells @FT "there was a safe way to make a vaccine available before the end of Phase 3 trials — potentially by issuing an emergency authorization for use by certain groups rather than a blanket approval.
cc: @ArthurCaplan @PeterHotez @angie_rasmussen
#COVID19 #vaccines
But then @SteveFDA "insisted he would not rush a vaccine to please" Trump.
So, Hahn is insisting he can safely put #COVID19 #vaccines on the U.S. market under emergency use without Phase 3 results but then says that's not to please Trump.
Read 6 tweets
Update tonight following my story: #FDA "is also prepared to rapidly schedule additional meetings of this committee upon submission of any applications as appropriate." -- @SteveFDA

#COVID19 #vaccines #VRBPAC
Noting: I repeatedly asked #FDA if it would hold #COVID19 vaccine-specific adcoms before the agency granted EUA or licensure. FDA declined yesterday to commit to holding any vaccine-specific adcoms prior to EUA or licensure. Hahn tonight now saying FDA is "prepared" to do so.
So what's the point of Oct. 22 adcom if #FDA will hold #COVID19 vaccine-specific adcoms now (again, Thursday they refused to commit to doing that). After a lot of criticism, @SteveFDA Hahn now saying they are "prepared" to [prepared is not commitment].
spglobal.com/marketintellig…
Read 13 tweets
Seriously, how is this going to repair @SteveFDA's reputation? He's a doctor & #COVID19 #convalescentplasma misstatements were his.

Is he pinning that on the PRs? Is he going to say the PRs came up with his lame excuses for why he made those false claims?

Again, he's a doctor?
This was all @SteveFDA, a doctor who should have known better [and maybe really did] about what he was saying about the #ConvalescentPlasma data in #COVID19
This was @SteveFDA making his excuses for his misleading information about #ConvalescentPlasma in #COVID19, not his #FDA PRs. He was the one out there saying these things cbsnews.com/video/fda-comm…
Read 11 tweets
We reviewed the first analysis of mortality among patients receiving #ConvalescentPlasma therapy from #COVID19 survivors through the US Expanded Access Program. The effect of #ConvalescentPlasma on #COVID19 mortality has not previously been well described bit.ly/3gpFGDn
In full disclosure, the lead author is based at Hopkins; however, none of the NCRC reviewers were direct collaborators. Thus, the article had an independent external review by someone without current or past professional collaborations with the author and no Hopkins affiliation.
In this preprint on @medrxivpreprint, Joyner et al analyzed 35,322 hospitalized #COVID19 patients from 1,809 sites overseen by @MayoClinic, from April 4-July 4. They assessed if timing of #ConvalescentPlasma reduced #mortality and if higher doses of #antibodies reduced mortality.
Read 9 tweets
.@MarkMeadows had already made it clear Trump was putting pressure on #FDA.

"He had to make sure that they felt the heat. If they don't see the light, they need to feel the heat."

Meadows also emphasized people who disagree get "relocated."

spglobal.com/marketintellig…
And @DrPaulOffit said he is aware of bullying of #FDA by the White House.

@SteveFDA can keep claiming no political pressure. But Trump & Meadows with their own words make it clear it is going on.

How credible is Hahn on anything after Sunday night?
spglobal.com/marketintellig…
.@SteveFDA in his tweets & his @CBSThisMorning wants to make it sound like he just got tangled in words in explaining his "35% improvement in survival" with #ConvalescentPlasma Sunday night.

But @SecAzar repeated it. #FDA, #HHS, White House tweeted it.

Read 3 tweets
.@SteveFDA: I personally could have done a better job & could have done a better job at that press conference.
He insists there's promising efficacy & safety data per @MayoClinic.
Data totally support EUA for #ConvalescentPlasma
He says #FDA scientists made decision.
#COVID19
.@SteveFDA: @MayoClinic data/identified a group #ConvalescentPlasma benefited most. Asked for additional validation data which supported; comparing those high concentrations of antibody vs low. When look at those data, survival benefit between 2 groups has relative benefit of 35%
.@SteveFDA: Timing #convalescentplasma EUA was totally based on when we got the data.
Had back & forth with NIH & internally about what data needed.
@MayoClinic expanded access timed to end this week.
Wanted to maintain availability.
Those are the facts.

#FDA #COVID19
Read 25 tweets
#FDA is being bullied by the White House and pressured to allow emergency use of products to treat #COVID19 without the data to back up those actions, @DrPaulOffit said.

#ConvalescentPlasma #vaccines
.@DrPaulOffit said he was concerned the #FDA would be forced by Trump to rush a #COVID19 vaccine to the market under an EUA before the product was thoroughly vetted.

#ConvalescentPlasma #vaccines #hydroxychloroquine
.@DrPaulOffit said the EUA for #ConvalescentPlasma concerns him that "it sets yet another precedent to make you worried about the fact that the administration is willing to bully its science-based agencies."

#COVID19 #vaccines #FDA
Read 3 tweets

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