Discover and read the best of Twitter Threads about #CoronaVirus2
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Briefing on Gene knockdown and knockout in today's #365DaysOfScience. These two are classical genome editing tools used to study gene function and probable effects of inhibiting the target gene. These tools find relevance in molecular genetics and drug discovery.
Gene knockout is the 'knocking out' of a gene. It is attributed by the permanent deactivation or complete elimination of gene function to evaluate the functional specificity of that gene. It is achieved by homologous recombination, endonucleases, or CRISPR/Cas9.
#365DaysOfScience
#365DaysOfScience
Using Gene knockdown the functional expression of a gene is suppressed in a flexible way. This approach is neccesiated for the genes whose KO will have a lethal effect. Working with RNA, it uses RNAi (siRNA/shRNA) leading to abortive translation/mRNA degradation
#365DaysOfScience
#365DaysOfScience
9/gpc Intensity of exposure to Corona virus matters. Which is why all household members get sick if they don't take precautions during home quarantine of one member. It's also why bars, party rooms & public bathrooms are most dangerous.
10/gpc This means we will have to follow the five safety precautions mentioned in first tweet & repeated in 🧵, even after new cases decline(ie for 6-12 months) : bit.ly/2FB7mZa
11/gpc The five fold path out of Covid19 #Masks, #Hygiene, #Distancing, #Ventilation/#UVfilteration , #TTQ
